RESUMO
This paper is to report the polymorphism of raw materials of clopidogrel bisulfate at home and abroad. By the analysis of Fourier transform infrared spectroscopy (FTIR) and powder X-ray diffraction (p-XRD), samples are roughly classified into two groups, except one patent material. And the differential scanning calorimeter (DSC) examination showed more detailed information for these materials. The results of the study could provide comprehensive basis for the quality evaluation of clopidogrel bisulfate.
Assuntos
Inibidores da Agregação Plaquetária/química , Ticlopidina/análogos & derivados , Varredura Diferencial de Calorimetria , Clopidogrel , Cristalização , Estudos de Avaliação como Assunto , Espectroscopia de Infravermelho com Transformada de Fourier , Ticlopidina/química , Difração de Raios XRESUMO
To cultivate oriented new varieties, Saposhnikovia divaricata seeds were carried by Shenzhou "3" satellite and filtered when they were being brought back. In the present paper, X-ray fluorescence(XRF) was used to mensurate and analyze the contents of elements of the two samples from the ground group and the 4th generation of space Saposhnikovia divaricata (space group) that have advantages in branches and leaves and yields. The contents of the main mineral elements in the two samples are the same basically. But the contents of the elements Zn, Fe, Mn and Cu from the outer group are higher than the ground group. Especially the contents of Zn, Fe, Mn and Cu concerning the curative effect in the space group increase 4.39, 1.23, 0.84 and 0.9 times as compared to the ground group. In the space group the contents and proportions of the mineral elements are improved and optimized. XRF method can be used for overall element analysis of and research on Chinese herbal medicines. Space flight breeding is an effective method for the selection of new Saposhnikovia divaricata breed.
Assuntos
Apiaceae/química , Voo Espacial , Espectrometria por Raios X/métodos , Oligoelementos/análise , MutagêneseRESUMO
OBJECTIVE: To establish a method for analyzing amorphous organic compound components of space Platycodon grandflorum rapidly. METHOD: FTIR was applied for measuring and comparing P. grandflorum of comparison group,the ground group and the 4" generation of space group. RESULT: Several active components (platycodin, polysaccharide etc.) contents of space group are increased obviously. CONCLUSION: The major components and the structures remained inextenso,and the effictive component contents are enhanced in the space P. grandiflorum. FTIR is a fast method to analyze the changes of amorphous organic compound components of the space traditional Chinese medicines.