1.
Org Lett
; 18(21): 5568-5571, 2016 11 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27740762
RESUMO
Efavirenz is manufactured worldwide, and its asymmetric synthesis requires a complex organometallic approach, while an organocatalytic approach is far less efficient. The first highly enantioselective approach is disclosed for the synthesis of Efavirenz under nonmetal organocatalysis with up to 93% ee for the Merck intermediate and 91% ee for the Lonsa intermediate using novel alkynyl cinchona catalysts.