Changes in Blood Pressure is Associated with Bone Loss in US Adults: A Cross-Sectional Study from NHANES 2005-2018.

Hypertension and osteoporosis are common geriatric diseases, sharing similar risk factors. This study aims to investigate this association and explore relatively mixed variables. Our study included 12,787 eligible participants from the National Health and Nutrition Examination Survey (NHANES) 2005-2018. Included participants had valid data on hypertension and osteoporosis, without tumors, liver diseases, gout or thyroid diseases. We explored the association between hypertension and osteoporosis by logistic regression and examined blood pressure and BMD/BMC by linear and non-linear regression. Moreover, we used machine learning models to predict the importance of various factors in the occurrence of osteoporosis and evaluated causality by mendelian randomization. Our study found that osteoporosis is significantly associated with hypertension [OR 2.072 (95% CI 2.067-2.077), p < 0.001]. After adjusting for co-variances, the association remained significant [OR 1.223 (95% CI 1.220-1.227), p < 0.001]. Our study showed that osteoporosis is positively associated with hypertension in the US population. A variety of factors influence this relationship. Specific regulatory mechanisms and confounding factors need to be further investigated.

Research on the Asymmetric Phenomenon of Voltage Polarity Based on Dielectric Wetting.

The present research investigated the voltage polarity asymmetry phenomenon based on dielectric wetting. In an ITO-hydrophobic layer-droplet setup, three reagents with different pH values (3.96, 7.0, and 10.18), two types of hydrophobic materials (AF1601 and 6%T6), and two different thicknesses (340 nm and 2.5 µm) of each material were systematically investigated. The results show that the thickness of the hydrophobic dielectric layer and the pH of the droplets had a significant impact on the droplet contact angle variation with the voltage. The contact angle on the thick hydrophobic dielectric layer followed the Lippmann-Young equation as the voltage changed. The angle of the thin hydrophobic dielectric layer was affected by its own properties and the type of droplet, which led to the occurrence of voltage polarity asymmetry of the electrowetting phenomenon. After further investigation of this phenomenon, it was found that it mainly accounted for the decrease in electric field strength at both ends of the droplet, which was caused by electrochemical reactions and changes in circuit resistance. The leakage current is an important indicator, and this phenomenon can be prevented by increasing the thickness of the hydrophobic dielectric layer.