Detalhe da pesquisa
1.
Fluorine Modifications Contribute to Potent Antiviral Activity against Highly Drug-Resistant HIV-1 and Favorable Blood-Brain Barrier Penetration Property of Novel Central Nervous System-Targeting HIV-1 Protease Inhibitors In Vitro.
Antimicrob Agents Chemother
; 66(2): e0171521, 2022 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34978889
2.
Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications.
Antimicrob Agents Chemother
; 63(7)2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31061155
3.
Proteasome dynamics between proliferation and quiescence stages of Saccharomyces cerevisiae.
Crit Rev Biochem Mol Biol
; 51(6): 497-512, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27677933
4.
A Modified P1 Moiety Enhances In Vitro Antiviral Activity against Various Multidrug-Resistant HIV-1 Variants and In Vitro Central Nervous System Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413.
Antimicrob Agents Chemother
; 60(12): 7046-7059, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27620483
5.
C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir.
J Virol
; 90(5): 2180-94, 2015 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26581995
6.
A conserved hydrogen-bonding network of P2 bis-tetrahydrofuran-containing HIV-1 protease inhibitors (PIs) with a protease active-site amino acid backbone aids in their activity against PI-resistant HIV.
Antimicrob Agents Chemother
; 58(7): 3679-88, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24752271
7.
P2' benzene carboxylic acid moiety is associated with decrease in cellular uptake: evaluation of novel nonpeptidic HIV-1 protease inhibitors containing P2 bis-tetrahydrofuran moiety.
Antimicrob Agents Chemother
; 57(10): 4920-7, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23877703
8.
Conserved hydrogen bonds and water molecules in MDR HIV-1 protease substrate complexes.
Biochem Biophys Res Commun
; 430(3): 1022-7, 2013 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-23261453
9.
Insights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex.
Biochem Biophys Res Commun
; 431(2): 232-8, 2013 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23313846
10.
Crystallographic study of multi-drug resistant HIV-1 protease lopinavir complex: mechanism of drug recognition and resistance.
Biochem Biophys Res Commun
; 437(2): 199-204, 2013 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23792096
11.
Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease.
Biochem Biophys Res Commun
; 438(4): 703-8, 2013 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23921229
12.
Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds.
Biochem Biophys Res Commun
; 421(3): 413-7, 2012 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-22469467
13.
Success of Current COVID-19 Vaccine Strategies vs. the Epitope Topology of SARS-CoV-2 Spike Protein-Receptor Binding Domain (RBD): A Computational Study of RBD Topology to Guide Future Vaccine Design.
Vaccines (Basel)
; 10(6)2022 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35746449
14.
Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants.
Acta Crystallogr D Biol Crystallogr
; 67(Pt 6): 524-32, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21636892
15.
Novel HIV-1 protease inhibitors (PIs) containing a bicyclic P2 functional moiety, tetrahydropyrano-tetrahydrofuran, that are potent against multi-PI-resistant HIV-1 variants.
Antimicrob Agents Chemother
; 55(4): 1717-27, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21282450
16.
A Novel Polar Core and Weakly Fixed C-Tail in Squid Arrestin Provide New Insight into Interaction with Rhodopsin.
J Mol Biol
; 430(21): 4102-4118, 2018 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30120952
17.
Crystal structure of the extracellular domain of human myelin protein zero.
Proteins
; 80(1): 307-13, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21971831
18.
AAA-ATPases in Protein Degradation.
Front Mol Biosci
; 4: 42, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28676851
19.
GRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane -Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants in vitro.
Sci Rep
; 7(1): 12235, 2017 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28947797
20.
Ubiquitin orchestrates proteasome dynamics between proliferation and quiescence in yeast.
Mol Biol Cell
; 28(19): 2479-2491, 2017 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28768827