Detalhe da pesquisa
1.
The full spectrum of SLC22 OCT1 mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics.
Mol Cell
; 84(10): 1932-1947.e10, 2024 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38703769
2.
Structural and molecular basis of choline uptake into the brain by FLVCR2.
Nature
; 629(8012): 704-709, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38693257
3.
Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools.
Nat Chem Biol
; 20(1): 62-73, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37474759
4.
Initial Insights into the Genetic Variation Associated with Metformin Treatment Failure in Youth with Type 2 Diabetes.
Pediatr Diabetes
; 20232023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38590442
5.
Characterization of P-glycoprotein orthologs from human, sheep, pig, dog, and cat.
J Vet Pharmacol Ther
; 46(6): 401-412, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37198956
6.
Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue.
PLoS Biol
; 17(1): e2006571, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30653498
7.
High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3.
Pharm Res
; 39(7): 1599-1613, 2022 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-35089508
8.
Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies.
PLoS Genet
; 15(9): e1008208, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31553721
9.
Emerging Roles of the Human Solute Carrier 22 Family.
Drug Metab Dispos
; 2021 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34921098
10.
Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies.
FASEB J
; 34(12): 15734-15752, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33124720
11.
Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content.
PLoS Biol
; 16(4): e2002907, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29659562
12.
GenEpi: gene-based epistasis discovery using machine learning.
BMC Bioinformatics
; 21(1): 68, 2020 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32093643
13.
Functional and structural analysis of rare SLC2A2 variants associated with Fanconi-Bickel syndrome and metabolic traits.
Hum Mutat
; 40(7): 983-995, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30950137
14.
Genomic Characterization of Metformin Hepatic Response.
PLoS Genet
; 12(11): e1006449, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27902686
15.
Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity.
Mol Pharmacol
; 94(1): 689-699, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29720497
16.
Computational Discovery and Experimental Validation of Inhibitors of the Human Intestinal Transporter OATP2B1.
J Chem Inf Model
; 57(6): 1402-1413, 2017 06 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28562037
17.
OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.
Proc Natl Acad Sci U S A
; 111(27): 9983-8, 2014 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24961373
18.
Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells.
Drug Metab Dispos
; 44(3): 356-64, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26700958
19.
Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin.
Mol Pharmacol
; 88(1): 75-83, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25920679
20.
Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3).
Mol Pharm
; 12(12): 4301-10, 2015 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26528626