Detalhe da pesquisa
1.
A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment.
Proc Natl Acad Sci U S A
; 118(13)2021 03 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-33753481
2.
Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice.
J Biomed Sci
; 29(1): 53, 2022 Jul 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35871686
3.
Protective Effect of CXCR4 Antagonist DBPR807 against Ischemia-Reperfusion Injury in a Rat and Porcine Model of Myocardial Infarction: Potential Adjunctive Therapy for Percutaneous Coronary Intervention.
Int J Mol Sci
; 23(19)2022 Oct 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36233031
4.
Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors.
Bioorg Chem
; 98: 103689, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32171993
5.
Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium-dependent glucose co-transporter 2 inhibitors.
Bioorg Chem
; 83: 520-525, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30469144
6.
Correction: 2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition.
Org Biomol Chem
; 16(25): 4734, 2018 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29904758
7.
4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy.
Bioorg Chem
; 77: 600-607, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29494816
8.
Targeting Tumor Associated Phosphatidylserine with New Zinc Dipicolylamine-Based Drug Conjugates.
Bioconjug Chem
; 28(7): 1878-1892, 2017 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28581724
9.
1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine.
Anesthesiology
; 126(5): 952-966, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28212204
10.
In vitro and in vivo studies of a potent capsid-binding inhibitor of enterovirus 71.
J Antimicrob Chemother
; 71(7): 1922-32, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27098012
11.
Activation of delta-opioid receptor contributes to the antinociceptive effect of oxycodone in mice.
Pharmacol Res
; 111: 867-876, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27496654
12.
2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition.
Org Biomol Chem
; 14(2): 716-723, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26694589
13.
N-Indolylglycosides bearing modifications at the glucose C6-position as sodium-dependent glucose co-transporter 2 inhibitors.
Bioorg Med Chem
; 24(10): 2242-50, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27075813
14.
Novel Nrf2/ARE activator, trans-Coniferylaldehyde, induces a HO-1-mediated defense mechanism through a dual p38α/MAPKAPK-2 and PK-N3 signaling pathway.
Chem Res Toxicol
; 28(9): 1681-92, 2015 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26275128
15.
Discovery of a Long Half-Life AURKA Inhibitor to Treat MYC-Amplified Solid Tumors as a Monotherapy and in Combination with Everolimus.
Mol Cancer Ther
; 23(6): 766-779, 2024 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38592383
16.
Discovery of Dual MER/AXL Kinase Inhibitors as Bifunctional Small Molecules for Inhibiting Tumor Growth and Enhancing Tumor Immune Microenvironment.
J Med Chem
; 2024 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38913493
17.
Resistance studies of a dithiazol analogue, DBPR110, as a potential hepatitis C virus NS5A inhibitor in replicon systems.
Antimicrob Agents Chemother
; 57(2): 723-33, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23165461
18.
1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines histone deacetylase inhibitors are potent cytokine release suppressors.
Chembiochem
; 14(10): 1248-54, 2013 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23788254
19.
BPR0C305, an orally active microtubule-disrupting anticancer agent.
Anticancer Drugs
; 24(10): 1047-57, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24025560
20.
Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).
Bioorg Med Chem
; 21(11): 2856-67, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23618709