Detalhe da pesquisa
1.
Modular Approaches to Lankacidin Antibiotics.
J Am Chem Soc
; 142(35): 15116-15126, 2020 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32786797
2.
Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy.
Bioorg Med Chem
; 26(1): 232-244, 2018 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29198609
3.
Synthesis of a series of unsaturated ketone derivatives as selective and reversible monoamine oxidase inhibitors.
Bioorg Med Chem
; 23(19): 6486-96, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26337020
4.
Discovery of Novel Sphingosine-1-Phosphate-1 Receptor Agonists for the Treatment of Multiple Sclerosis.
J Med Chem
; 65(4): 3539-3562, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35077170
5.
Optimization and Evaluation of Novel Antifungal Agents for the Treatment of Fungal Infection.
J Med Chem
; 64(21): 15912-15935, 2021 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34662122
6.
Modulation of CRMP2 via (S)-Lacosamide shows therapeutic promise but is ultimately ineffective in a mouse model of CLN6-Batten disease.
Neuronal Signal
; 3(2): NS20190001, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32269836
7.
Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer's disease.
Sci Adv
; 5(3): eaav0316, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30906861
8.
CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation.
Mol Neurobiol
; 55(5): 4403-4416, 2018 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-28660485
9.
CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide.
Pain
; 158(12): 2301-2319, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28809766
10.
(S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5.
Mol Neurobiol
; 53(3): 1959-1976, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25846820
11.
(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology.
Pain
; 157(7): 1448-1463, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26967696
12.
Screening, Synthesis, and In Vitro Evaluation of Vinyl Sulfones as Inhibitors of Complement-Dependent Cytotoxicity in Neuromyelitis Optica.
ChemMedChem
; 11(4): 377-81, 2016 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26804736
13.
Discovery of vinyl sulfones as a novel class of neuroprotective agents toward Parkinson's disease therapy.
J Med Chem
; 57(4): 1473-87, 2014 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24467268