Detalhe da pesquisa
1.
Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50.
J Virol
; 87(8): 4176-84, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23365446
2.
Direct delivery of stabilized Cas-embedded base editors achieves efficient and accurate editing of clinically relevant targets.
bioRxiv
; 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38370706
3.
Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease.
ACS Infect Dis
; 9(7): 1372-1386, 2023 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37390404
4.
HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues.
Eur J Med Chem
; 257: 115501, 2023 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37244161
5.
Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance.
Elife
; 122023 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36920025
6.
Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms.
Elife
; 112022 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35723575
7.
Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants.
Front Immunol
; 13: 995412, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36172366
8.
Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes.
Nat Metab
; 2(9): 934-945, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32719542
9.
IgA MAb blocks SARS-CoV-2 Spike-ACE2 interaction providing mucosal immunity.
bioRxiv
; 2020 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32511396
10.
HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands To Optimize Hydrogen Bonding in the Substrate Envelope.
J Med Chem
; 62(17): 8062-8079, 2019 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31386368
11.
Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
ACS Infect Dis
; 5(2): 316-325, 2019 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30543749
12.
Dengue Protease Substrate Recognition: Binding of the Prime Side.
ACS Infect Dis
; 2(10): 734-743, 2016 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27657335
13.
Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance.
Chem Biol
; 20(9): 1116-24, 2013 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-24012370
14.
Differential Flap Dynamics in Wild-type and a Drug Resistant Variant of HIV-1 Protease Revealed by Molecular Dynamics and NMR Relaxation.
J Chem Theory Comput
; 8(10): 3452-3462, 2012 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-23144597
15.
Extreme entropy-enthalpy compensation in a drug-resistant variant of HIV-1 protease.
ACS Chem Biol
; 7(9): 1536-46, 2012 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22712830