RESUMO
In the presence of a catalytic amount of a simple copper salt, the coupling of imidazole with arylboronic acids was performed in methanol to give corresponding N-arylimidazoles in almost quantitative yields; this coupling reaction could also be performed in aqueous solutions to give N-arylimidazoles in excellent yields.
RESUMO
A synthetic route to novel chiral PNA monomer-cyclen conjugates was described for the first time, the targeted products were obtained in high yields under mild reaction conditions. The preliminary results demonstrated that the uracil-PNA monomer-cyclen conjugates can rapidly bind Zn2+ in aqueous solution, and the structure of the Zn(II) complex was confirmed facilely by HRMS spectra, 1H NMR spectra and elemental analysis.
Assuntos
Compostos Heterocíclicos/química , Compostos Organometálicos/síntese química , Ácidos Nucleicos Peptídicos/síntese química , Zinco/química , Dicroísmo Circular , Ciclamos , Compostos Organometálicos/química , Ácidos Nucleicos Peptídicos/química , Estereoisomerismo , Uracila/químicaRESUMO
The indexes of auxiliary laboratory diagnosis, including plasma norepinephine (NE) levels, plasma epinephrine (E) levels, mean blood flow velocity of the middle cerebral artery (MCA-Vm) and systolic blood flow velocity of the middle cerebral artery (MCA-Vs), were observed in patients with the syndrome of hyperactivity liver-yang. The results indicated that the levels of the 4 indexes were significantly higher in the patients with the syndrome of hyperactivity liver-yang than those in the controls. In hypertension patients with the syndrome of hyperactivity liver-yang, there was a positive correlation between symptomatic scores of the syndrome of hyperactivity liver-yang and diastolic pressure (Pd), plasma NE and E levels. The symptoms ameliorated, and the levels of the 4 indexes decreased correspondingly in 3 weeks after the treatment of Qianyangfang (a traditional Chinese herb).