Detalhe da pesquisa
1.
Insertion of 4-Demethylwyosine in tRNAPhe Catalyzed by the Radical S-Adenosyl-l-methionine Enzyme TYW1 Entails Oxidative Cleavage of Pyruvate to Form CO2.
Biochemistry
; 61(23): 2643-2647, 2022 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36326713
2.
Eukaryotic TYW1 Is a Radical SAM Flavoenzyme.
Biochemistry
; 60(27): 2179-2185, 2021 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34184886
3.
New Role for Radical SAM Enzymes in the Biosynthesis of Thio(seleno)oxazole RiPP Natural Products.
Biochemistry
; 60(45): 3347-3361, 2021 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34730336
4.
Biochemical and Structural Characterization of a Schiff Base in the Radical-Mediated Biosynthesis of 4-Demethylwyosine by TYW1.
J Am Chem Soc
; 140(22): 6842-6852, 2018 06 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29792696
5.
Human Viperin Causes Radical SAM-Dependent Elongation of Escherichia coli, Hinting at Its Physiological Role.
Biochemistry
; 56(30): 3874-3876, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28708394
6.
Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism.
Nat Chem Biol
; 10(2): 106-12, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24362703
7.
Mechanistic Studies of the Radical S-Adenosyl-L-methionine Enzyme 4-Demethylwyosine Synthase Reveal the Site of Hydrogen Atom Abstraction.
Biochemistry
; 54(23): 3569-72, 2015 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26052987
8.
Chemical and Biological Reduction of the Radical SAM Enzyme 7-Carboxy-7-deazaguanine [corrected] Synthase.
Biochemistry
; 54(18): 2903-10, 2015 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25933252
9.
Pyruvate is the source of the two carbons that are required for formation of the imidazoline ring of 4-demethylwyosine.
Biochemistry
; 50(49): 10573-5, 2011 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22026549
10.
Correction to Chemical and Biological Reduction of the Radical SAM Enzyme 7-Carboxy-7-deazaguanine Synthase.
Biochemistry
; 55(12): 1939, 2016 Mar 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-26950390
11.
Production of Transgenic Mice by Pronuclear Microinjection.
Methods Mol Biol
; 1874: 17-41, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30353506
12.
TYW1: A Radical SAM Enzyme Involved in the Biosynthesis of Wybutosine Bases.
Methods Enzymol
; 606: 119-153, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30097090
13.
Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine.
Curr Opin Chem Biol
; 17(4): 613-8, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23856057
14.
A promoter element with enhancer properties, and the orphan nuclear receptor RORalpha, are required for Purkinje cell-specific expression of a Gi/o modulator.
Mol Cell Neurosci
; 34(3): 324-42, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17215137