Detalhe da pesquisa
1.
Rational design and synthesis of triazene-amonafide derivatives as novel potential antitumor agents causing oxidative damage towards DNA through intercalation mode.
Bioorg Chem
; 144: 107141, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38244381
2.
De novo design of dual-target JAK2, SMO inhibitors based on deep reinforcement learning, molecular docking and molecular dynamics simulations.
Biochem Biophys Res Commun
; 638: 23-27, 2023 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36436338
3.
Electrochemical detection of the oxidative damage of a potential pyrimido[5,4-g]pteridine-derived antitumor agent toward DNA.
Anal Bioanal Chem
; 415(12): 2249-2260, 2023 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-36920495
4.
Design, Synthesis and Structure-Activity Relationship Studies of Meridianin Derivatives as Novel JAK/STAT3 Signaling Inhibitors.
Int J Mol Sci
; 23(4)2022 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35216314
5.
Discovery of DNA Topoisomerase I Inhibitors with Low-Cytotoxicity Based on Virtual Screening from Natural Products.
Mar Drugs
; 15(7)2017 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28698495
6.
Discovery and design of dual inhibitors targeting Sphk1 and Sirt1.
J Mol Model
; 29(5): 141, 2023 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37059848
7.
Electrochemical detection of genetic damage caused by the interaction of novel bifunctional anthraquinone-temozolomide antitumor hybrids with DNA modified electrode.
J Pharm Biomed Anal
; 231: 115410, 2023 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37087773
8.
Design of SARS-CoV-2 Mpro, PLpro dual-target inhibitors based on deep reinforcement learning and virtual screening.
Future Med Chem
; 14(6): 393-405, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35220726
9.
Deciphering the Underlying Mechanisms of Formula Le-Cao-Shi Against Liver Injuries by Integrating Network Pharmacology, Metabonomics, and Experimental Validation.
Front Pharmacol
; 13: 884480, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35548342
10.
Development of efficient docking strategies and structure-activity relationship study of the c-Met type II inhibitors.
J Mol Graph Model
; 75: 241-249, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28601708
11.
De novo design of VEGFR-2 tyrosine kinase inhibitors based on a linked-fragment approach.
J Mol Model
; 22(9): 222, 2016 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27558799
12.
The unbinding studies of vascular endothelial growth factor receptor-2 protein tyrosine kinase type II inhibitors.
J Mol Graph Model
; 59: 130-5, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25989626