Detalhe da pesquisa
1.
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations.
Cell
; 141(7): 1146-58, 2010 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20541250
2.
Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies.
Proc Natl Acad Sci U S A
; 110(9): 3537-42, 2013 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23297226
3.
Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling.
Neurobiol Dis
; 44(2): 215-22, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21782946
4.
Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease.
J Cell Biol
; 171(1): 87-98, 2005 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-16203860
5.
The role of glucocerebrosidase mutations in Parkinson disease and Lewy body disorders.
Curr Neurol Neurosci Rep
; 10(3): 190-8, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20425034
6.
Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease.
J Neurosci
; 28(27): 6926-37, 2008 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-18596167
7.
Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms.
J Neurosci
; 27(50): 13635-48, 2007 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18077675
8.
A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment.
Neurobiol Dis
; 31(1): 46-57, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18504134
9.
Pharmacologic inhibition of 5-lipoxygenase improves memory, rescues synaptic dysfunction, and ameliorates tau pathology in a transgenic model of tauopathy.
Biol Psychiatry
; 78(10): 693-701, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25802082
10.
Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo.
Autophagy
; 8(4): 609-22, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22361619
11.
The phospholipase D1 pathway modulates macroautophagy.
Nat Commun
; 1: 142, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-21266992
12.
Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing.
Neuron
; 57(5): 680-90, 2008 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18341989