Detalhe da pesquisa
1.
Safety, Tolerability, and Pharmacokinetics of MEDI4893, an Investigational, Extended-Half-Life, Anti-Staphylococcus aureus Alpha-Toxin Human Monoclonal Antibody, in Healthy Adults.
Antimicrob Agents Chemother
; 61(1)2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27795368
2.
pH-dependent binding engineering reveals an FcRn affinity threshold that governs IgG recycling.
J Biol Chem
; 290(7): 4282-90, 2015 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25538249
3.
Critical Role of Alpha-Toxin and Protective Effects of Its Neutralization by a Human Antibody in Acute Bacterial Skin and Skin Structure Infections.
Antimicrob Agents Chemother
; 60(10): 5640-8, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27401576
4.
Population pharmacokinetic analysis of sifalimumab from a clinical phase IIb trial in systemic lupus erythematosus patients.
Br J Clin Pharmacol
; 81(5): 918-28, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26659791
5.
Three monthly doses of palivizumab are not adequate for 5-month protection: a population pharmacokinetic analysis.
Pulm Pharmacol Ther
; 26(6): 666-71, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23523663
6.
Early toxicology signal generation in the mouse.
Toxicol Pathol
; 38(3): 452-71, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20305093
7.
Substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel tryptophan hydroxylase inhibitors.
Bioorg Med Chem Lett
; 19(17): 5229-32, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19631532
8.
Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract.
J Pharmacol Exp Ther
; 325(1): 47-55, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18192499
9.
Characterisation of anti-alpha toxin antibody levels and colonisation status after administration of an investigational human monoclonal antibody, MEDI4893, against Staphylococcus aureus alpha toxin.
Clin Transl Immunology
; 7(1): e1009, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29484186
10.
Enhancement of antibody functions through Fc multiplications.
MAbs
; 9(3): 393-403, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28102754
11.
Insertion of scFv into the hinge domain of full-length IgG1 monoclonal antibody results in tetravalent bispecific molecule with robust properties.
MAbs
; 9(2): 240-256, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-27981887
12.
Fractionated Dosing Improves Preclinical Therapeutic Index of Pyrrolobenzodiazepine-Containing Antibody Drug Conjugates.
Clin Cancer Res
; 23(19): 5858-5868, 2017 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28630216
13.
Generation and Characterization of an IgG4 Monomeric Fc Platform.
PLoS One
; 11(8): e0160345, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27479095
14.
Rational design, biophysical and biological characterization of site-specific antibody-tubulysin conjugates with improved stability, efficacy and pharmacokinetics.
J Control Release
; 236: 100-16, 2016 08 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27327768
15.
Improving target cell specificity using a novel monovalent bispecific IgG design.
MAbs
; 7(2): 377-89, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25621507
16.
Phase I dose-escalation study of MEDI-573, a bispecific, antiligand monoclonal antibody against IGFI and IGFII, in patients with advanced solid tumors.
Clin Cancer Res
; 20(18): 4747-57, 2014 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25024259
17.
A multifunctional bispecific antibody protects against Pseudomonas aeruginosa.
Sci Transl Med
; 6(262): 262ra155, 2014 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25391481
18.
Decreased intraocular pressure in mice following either pharmacological or genetic inhibition of ROCK.
J Ocul Pharmacol Ther
; 25(3): 187-94, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19456252
19.
Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders.
J Med Chem
; 51(13): 3684-7, 2008 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18557609
20.
The role of pharmacokinetic and pharmacokinetic/pharmacodynamic modeling in drug discovery and development.
Future Med Chem
; 2(6): 923-8, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21426110