Primary Acute Angle-Closure Glaucoma: Three-Dimensional Reconstruction Imaging of Optic Nerve Heard Structure in Based on Optical Coherence Tomography (OCT).

BACKGROUND In glaucoma, the cup to plate ratio enlargement is a recognized pathological phenomenon. At present, the research on optic nerve in China and abroad mainly focuses on 2-dimensional research, and the measurement of 3-dimensional volume data is less well studied. Therefore, the recognition of 3-dimensional morphological changes is conducive to timely clinical intervention to prevent or slow down progressive vision loss. MATERIAL AND METHODS In this paper, optical coherence tomography (OCT) volume imaging technology was used to analyze and compare the morphological changes of primary acute angle-closure glaucoma in three-dimensional morphology, reconstruct the volume data of three-dimensional optic nerve head (ONH), and make morphological measurements. RESULTS The rim width of the glaucoma group was significantly lower than that of the control group, and the average volume and intraocular pressure of the optic cup were significantly increased (P<0.05), while the rim width and intraocular pressure of the other group were not significantly changed (P>0.05). CONCLUSIONS We used three-dimensional reconstruction to identify OCT images between glaucoma patients and the control group with significant differences.

Functional MRI reveals effects of high intraocular pressure on central nervous system in high-tension glaucoma patients.

PURPOSE: To evaluate the effects of high intraocular pressure (IOP) on central nervous system in patients with high-tension glaucoma (HTG) by using resting-state functional magnetic resonance imaging (rs-fMRI). METHODS: Thirty-six patients with HTG and twenty age- and gender-matched healthy controls (HCs) were recruited and underwent IOP measurement and rs-fMRI scan. The whole brain regional homogeneity (ReHo) value was calculated among the enrolled subjects. Two-sample t tests with permutation test and threshold-free cluster enhancement was performed between HTG group and HCs. Correlation analyses between IOP and ReHo values were conducted. RESULTS: Compared with HCs, HTG group showed increased ReHo values in the left lobule 8 of cerebellar hemisphere, left lobule 4 and 5 of cerebellar hemisphere and left fusiform gyrus (FG) (p < 0.05). HTG group showed decreased ReHo value in the left middle frontal gyrus (MFG) (p < 0.05). Intraocular pressure of the left eye in HTG group experienced a significant positive correlation with ReHo value of the left FG (r = 0.370, p = 0.026), IOP of the right eye in HTG group showed a significant negative correlation with ReHo value in the left MFG (r = -0.421, p = 0.011). CONCLUSION: Resting-state fMRI ReHo analyses associated elevated IOP with abnormal regional activity in several brain regions related to higher visual function and visual memory consolidation. High-tension glaucoma patients also showed diminished integration of visual information and cerebellar function. These results may provide imaging support for pathophysiological research of HTG and may reveal new targets for the accurate treatment of HTG.

Extraction of posterior polar intraocular foreign bodies with sodium hyaluronate backsiphon technique.

PURPOSE: To explore the new technique on the removal of posterior polar intraocular foreign bodies (IOFBs). METHODS: Dint of viscoelasticity and cohesiveness of ophthalmic viscoelastics (sodium hyaluronate) was used to wrap, dissociate and suspend IOFBs. Then IOFBs were approached and backsiphoned by using self-made backsiphon syringe needles which were selected according to the size and shape of IOFBs. The IOFBs are removed with the inflow of sodium hyaluronate naturally surging into the needles. RESULTS: Posterior polar IOFBs in 13 cases (13 eyes) were all removed successfully at one time. There were no accidental injuries or complications. The postoperative vision in 11 cases (11 eyes) was improved, unchanged in 1 case (1 eye) and decreased in 1 case (1 eye). CONCLUSIONS: The technique using viscoelastics to dissociate, suspend and backsiphon IOFBs during the removal of the posterior polar IOFBs can evidently decrease operative difficulty, injury and complications.