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The impact of collisionless, energy-independent, and energy-dependent collisionality models on the kinetic stability of the resistive wall mode is examined for high pressure plasmas in the National Spherical Torus Experiment. Future devices will have decreased collisionality, which previous stability models predict to be universally destabilizing. In contrast, in kinetic theory reduced ion-ion collisions are shown to lead to a significant stability increase when the plasma rotation frequency is in a stabilizing resonance with the ion precession drift frequency. When the plasma is in a reduced stability state with rotation in between resonances, collisionality will have little effect on stability.
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Negative magnetic shear is found to suppress electron turbulence and improve electron thermal transport for plasmas in the National Spherical Torus Experiment (NSTX). Sufficiently negative magnetic shear results in a transition out of a stiff profile regime. Density fluctuation measurements from high-k microwave scattering are verified to be the electron temperature gradient (ETG) mode by matching measured rest frequency and linear growth rate to gyrokinetic calculations. Fluctuation suppression under negligible E×B shear conditions confirm that negative magnetic shear alone is sufficient for ETG suppression. Measured electron temperature gradients can significantly exceed ETG critical gradients with ETG mode activity reduced to intermittent bursts, while electron thermal diffusivity improves to below 0.1 electron gyro-Bohms.
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This Letter presents nonlinear gyrokinetic simulations of microtearing mode turbulence. The simulations include collisional and electromagnetic effects and use experimental parameters from a high-ß discharge in the National Spherical Torus Experiment. The predicted electron thermal transport is comparable to that given by experimental analysis, and it is dominated by the electromagnetic contribution of electrons free-streaming along the resulting stochastic magnetic field line trajectories. Experimental values of flow shear can significantly reduce the predicted transport.
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In this Letter we report the first clear experimental observation of density gradient stabilization of electron temperature gradient driven turbulence in a fusion plasma. It is observed that longer wavelength modes, k(â¥)ρ(s) â² 10, are most stabilized by density gradient, and the stabilization is accompanied by about a factor of 2 decrease in the plasma effective thermal diffusivity.
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We investigated the efficiency droop and polarization-induced internal electric field of InGaN blue light-emitting diodes (LEDs) grown on silicon(111) and c-plane sapphire substrates. The efficiency droop of the LED sample grown on silicon substrates was considerably lower than that of the identically fabricated LED sample grown on sapphire substrates. Consequently, the LED on silicon showed higher efficiency at a sufficiently high injection current despite the lower peak efficiency caused by the poorer crystal quality. The reduced efficiency droop for the LED on silicon was attributed to its lower internal electric field, which was confirmed by reverse-bias electro-reflectance measurements and numerical simulations. The internal electric field of the multiple quantum wells (MQWs) on silicon was found to be reduced by more than 40% compared to that of the MQWs on sapphire, which resulted in a more homogenous carrier distribution in InGaN MQWs, lower Auger recombination rates, and consequently reduced efficiency droop for the LEDs grown on the silicon substrates. Owing to its greatly reduced efficiency droop, the InGaN blue LED on silicon substrates is expected to be a good cost effective solution for future lighting technology.
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BACKGROUND: A highly effective vaccine against Plasmodium falciparum malaria should induce potent, strain transcending immunity that broadly protects against the diverse population of parasites circulating globally. We aimed to identify vaccine candidates that fulfill the criteria. METHODS: We have measured growth inhibitory activity of antibodies raised to a range of antigens to identify those that can efficiently block merozoite invasion for geographically diverse strains of P. falciparum. RESULTS: This has shown that the conserved Region III-V, of the P. falciparum erythrocyte-binding antigen (EBA)-175 was able to induce antibodies that potently inhibit merozoite invasion across diverse parasite strains, including those reliant on invasion pathways independent of EBA-175 function. Additionally, the conserved RIII-V domain of EBA-140 also induced antibodies with strong in vitro parasite growth inhibitory activity. CONCLUSION: We identify an alternative, highly conserved region (RIV-V) of EBA-175, present in all EBA proteins, that is the target of potent, strain transcending neutralizing antibodies, that represents a strong candidate for development as a component in a malaria vaccine.
Assuntos
Anticorpos Neutralizantes/sangue , Anticorpos Antiprotozoários/sangue , Antígenos de Protozoários/imunologia , Malária Falciparum/prevenção & controle , Plasmodium falciparum/imunologia , Proteínas de Protozoários/imunologia , Vacinação , Sequência de Aminoácidos , Animais , Anticorpos Neutralizantes/farmacologia , Anticorpos Antiprotozoários/farmacologia , Antígenos de Protozoários/química , Sequência Conservada , Mapeamento de Epitopos , Interações Hospedeiro-Parasita/imunologia , Humanos , Imunoglobulina G/sangue , Concentração Inibidora 50 , Vacinas Antimaláricas/imunologia , Malária Falciparum/sangue , Malária Falciparum/imunologia , Plasmodium falciparum/efeitos dos fármacos , Plasmodium falciparum/crescimento & desenvolvimento , Proteínas de Protozoários/química , Coelhos , Especificidade da EspécieRESUMO
Electron gyroscale fluctuation measurements in National Spherical Torus Experiment H-mode plasmas with large toroidal rotation reveal fluctuations consistent with electron temperature gradient (ETG) turbulence. Large toroidal rotation in National Spherical Torus Experiment plasmas with neutral beam injection generates ExB flow shear rates comparable to ETG linear growth rates. Enhanced fluctuations occur when the electron temperature gradient is marginally stable with respect to the ETG linear critical gradient. Fluctuation amplitudes decrease when the ExB flow shear rate exceeds ETG linear growth rates. The observations indicate that ExB flow shear can be an effective suppression mechanism for ETG turbulence.
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This work describes the implementation and recent results from the motional Stark effect (MSE) collisionally induced fluorescence diagnostic on NSTX. Due to the low magnetic field on NSTX the MSE diagnostic requires a new approach for the viewing optics and spectral filter. This has been accomplished with a novel optical design that reduces the geometric Doppler broadening, and a high throughput, high resolution spectral filter to optimize signal-to-noise ratio. With these improvements the polarization fraction is approximately 30%-40% and, combined with the large throughput, a time resolution of approximately 5 ms. The MSE diagnostic presently has 16 sight lines operating, providing measurements of the magnetic field line pitch from the plasma center to near the outboard edge of the plasma.
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The United States has been tasked with the development and implementation of a motional Stark effect (MSE) system on ITER. In the harsh ITER environment, MSE is particularly susceptible to degradation, as it depends on polarimetry, and the polarization reflection properties of surfaces are highly sensitive to thin film effects due to plasma deposition and erosion of a first mirror. Here we present the results of a comprehensive study considering a new MSE-based approach to internal plasma magnetic field measurements for ITER. The proposed method uses the line shifts in the MSE spectrum (MSE-LS) to provide a radial profile of the magnetic field magnitude. To determine the utility of MSE-LS for equilibrium reconstruction, studies were performed using the ESC-ERV code system. A near-term opportunity to test the use of MSE-LS for equilibrium reconstruction is being pursued in the implementation of MSE with laser-induced fluorescence on NSTX. Though the field values and beam energies are very different from ITER, the use of a laser allows precision spectroscopy with a similar ratio of linewidth to line spacing on NSTX as would be achievable with a passive system on ITER. Simulation results for ITER and NSTX are presented, and the relative merits of the traditional line polarization approach and the new line-shift approach are discussed.
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Experiments have been conducted at the National Sperical Torus Experiment (NSTX) to study both steady state and perturbative momentum transport. These studies are unique in their parameter space under investigation, where the low aspect ratio of NSTX results in rapid plasma rotation with ExB shearing rates high enough to suppress low-k turbulence. In some cases, the ratio of momentum to energy confinement time is found to exceed five. Momentum pinch velocities of order 10-40 m/s are inferred from the measured angular momentum flux evolution after nonresonant magnetic perturbations are applied to brake the plasma.
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Measurements with coherent scattering of electromagnetic waves in plasmas of the National Spherical Torus Experiment indicate the existence of turbulent fluctuations in the range of wave numbers k perpendicular rho(e)=0.1-0.4, corresponding to a turbulence scale length nearly equal to the collisionless skin depth. Experimental observations and agreement with numerical results from a linear gyrokinetic stability code support the conjecture that the observed turbulence is driven by the electron-temperature gradient.
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The resistive-wall mode is actively stabilized in the National Spherical Torus Experiment in high-beta plasmas rotating significantly below the critical rotation speed for passive stability and in the range predicted for the International Thermonuclear Experimental Reactor. Variation of feedback stabilization parameters shows mode excitation or suppression. Stabilization of toroidal mode number unity did not lead to instability of toroidal mode number two. The mode can become unstable by deforming poloidally, an important consideration for stabilization system design.
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A motional Stark effect diagnostic has been utilized to reconstruct the parallel current density profile in a spherical-torus plasma for the first time. The measured current profile compares favorably with neoclassical theory when no large-scale magnetohydrodynamic instabilities are present in the plasma. However, a current profile anomaly is observed during saturated interchange-type instability activity. This apparent anomaly can be explained by redistribution of neutral beam injection current drive and represents the first observation of interchange-type instabilities causing such redistribution. The associated current profile modifications contribute to sustaining the central safety factor above unity for over five resistive diffusion times, and similar processes may contribute to improved operational scenarios proposed for ITER.
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Dissipation of plasma toroidal angular momentum is observed in the National Spherical Torus Experiment due to applied nonaxisymmetric magnetic fields and their plasma-induced increase by resonant field amplification and resistive wall mode destabilization. The measured decrease of the plasma toroidal angular momentum profile is compared to calculations of nonresonant drag torque based on the theory of neoclassical toroidal viscosity. Quantitative agreement between experiment and theory is found when the effect of toroidally trapped particles is included.