RESUMO
The effect of L-lysine-alpha-oxidase from Trichoderma harzianum Rifai on the functional activity of T-lymphocytes was investigated. It was shown that in a dose of 35 units/kg administered parentally the enzyme had no suppressive effect on the T-lymphocyte functional activity. An inhibitory effect of L-lysine-a-oxidase on some indices of the macrophages functional activity was observed. L-Lyzine-alpha-oxidase had a selective lymphotropic action and showed no mytostatic activity, which is in favour of the enzyme vs. other antitumor agents.
Assuntos
Aminoácido Oxirredutases/farmacologia , Antineoplásicos/farmacologia , Macrófagos Peritoneais/efeitos dos fármacos , Linfócitos T/efeitos dos fármacos , Trichoderma/enzimologia , 5'-Nucleotidase/metabolismo , Aminoácido Oxirredutases/isolamento & purificação , Animais , Antineoplásicos/isolamento & purificação , Proliferação de Células/efeitos dos fármacos , Células Cultivadas , Relação Dose-Resposta a Droga , Imunomodulação , Injeções Intraperitoneais , Camundongos , Camundongos Endogâmicos CBARESUMO
The effect of L-lysine-alpha-oxidase from a representative of the Trichoderma genus on the humoral immune response to protein antigens was studied. It was shown that repeated fife-fold intravenous administrations of L-lysine-alpha-oxidase in a dose of 35 U/kg had no depressive action on the humoral immunity. The enzyme had no suppressive effect on the delayed type hypersensitivity to xenogenous erythrocytes. The use of L-lysine-alpha-oxidase in a therapeutic dose or in a twice as higher dose had no reliable effect on the leukocyte migration capacity vs. the control.