RESUMO
Local irradiation with pulsed (1500 Hz) low-energy infrared laser light of the thymus and thyroid gland region caused well-apparent stimulation of alpha-1-thymosin production in the healthy animals and normalized its level in the stressed ones. Similar stimulation of alpha-1-timosine biosynthesis was observed in an experiment with direct laser irradiation of the cultured HTSC epitheliocytes from the human thymus.
Assuntos
Lasers , Timosina/análogos & derivados , Timo/metabolismo , Animais , Células Cultivadas , Humanos , Terapia com Luz de Baixa Intensidade , Masculino , Ratos , Estresse Fisiológico/fisiologia , Estresse Fisiológico/efeitos da radiação , Timalfasina , Timosina/biossíntese , Timo/citologiaRESUMO
The use of the methods of multiple (35) precordial ECG leads and serial tests for the activity of creatine phosphokinase and its MB fraction allows quantitative assessment of the dimensions of the necrotic zones. In injection of contrykal with heparin the dimensions of the myocardial infarct decreased. In early injection of these agents, the clinical and electrocardiographic findings improved more rapidly and the infarction zone was smaller. Injection of contrykal with heparin arrested the anginose attack more rapidly, corrected the peripheral symptoms of circulatory insufficiency, normalized arterial pressure and relieved the congestive phenomena in the lungs within a shorter period of time. The combined use of these agents is a pathogenetically substantiated method for the treatment of patients in the acute period of myocardial infarction for the purpose of restricting the dimensions of the ischemic damage to the myocardium.
Assuntos
Aprotinina/administração & dosagem , Heparina/administração & dosagem , Infarto do Miocárdio/tratamento farmacológico , Inibidores de Proteases/administração & dosagem , Doença Aguda , Adulto , Idoso , Creatina , Creatina Quinase/sangue , Quimioterapia Combinada , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/enzimologia , Infarto do Miocárdio/patologia , Miocárdio/patologiaRESUMO
The natural history and extension of myocardial infarction were studied from parameters of precordial ECG in 35 leads and central hemodynamic findings in 100 patients with acute myocardial infarction. The least extension of myocardial lesion areas and better central hemodynamic parameters and a sharp reduction in the frequency of complications and hospital mortality in patients receiving a combined therapy with contrykal and nitroglycerin as a continuous long-term infusion within the first 24 hours of myocardial infarction as compared with the controls and in those having these agents alone.