RayStation/GATE Monte Carlo simulation framework for verification of proton therapy based on the12N imaging.

Objective.12N, having a half-life of 11 ms, is a highly effective positron emitter that can potentially provide near real-time feedback in proton therapy. There is currently no framework for comparing and validating positron emission imaging of12N. This work describes the development and validation of a Monte Carlo (MC) framework to calculate the images of12N, as well as long-lived isotopes, originating from activation by protons.Approach. The available dual-panel Biograph mCT PET scanner was modeled in GATE and validated by comparing the simulated sensitivity map with the measured one. The distributions of12N and long-lived isotopes were calculated by RayStation and used as the input of GATE simulations. The RayStation/GATE combination was verified using proton beam irradiations of homogeneous phantoms. A 120 MeV pulsed pencil beam with 108protons per pulse was used. Two-dimensional images were created from the GATE output and compared with the images based on the measurements and the 1D longitudinal projection of the full 2D image was used to calculate the12N activity range.Main results. The simulated sensitivity in the center of the FoV (5.44%) agrees well with the measured one (5.41%). The simulated and measured 2D sensitivity maps agree in good detail. The relative difference between the measured and simulated positron activity range for both12N and long-lived isotopes is less than 1%. The broadening of the12N images relative to those of the longer-lived isotopes can be understood in terms of the large positron range of12N.Significance. We developed and validated a MC framework based on RayStation/GATE to support the in-beam PET method for quality assurance of proton therapy. The inclusion of the very short-lived isotope12N makes the framework useful for developing near real-time verification. This represents a significant step towards translating12N real-time in vivo verification to the clinic.

Measurement of the12C(p,n)12N reaction cross section below 150 MeV.

Objective. Proton therapy currently faces challenges from clinical complications on organs-at-risk due to range uncertainties. To address this issue, positron emission tomography (PET) of the proton-induced11C and15O activity has been used to provide feedback on the proton range. However, this approach is not instantaneous due to the relatively long half-lives of these nuclides. An alternative nuclide,12N (half-life 11 ms), shows promise for real-timein vivoproton range verification. Development of12N imaging requires better knowledge of its production reaction cross section.Approach. The12C(p,n)12N reaction cross section was measured by detecting positron activity of graphite targets irradiated with 66.5, 120, and 150 MeV protons. A pulsed beam delivery with 0.7-2 × 108protons per pulse was used. The positron activity was measured during the beam-off periods using a dual-head Siemens Biograph mCT PET scanner. The12N production was determined from activity time histograms.Main results. The cross section was calculated for 11 energies, ranging from 23.5 to 147 MeV, using information on the experimental setup and beam delivery. Through a comprehensive uncertainty propagation analysis, a statistical uncertainty of 2.6%-5.8% and a systematic uncertainty of 3.3%-4.6% were achieved. Additionally, a comparison between measured and simulated scanner sensitivity showed a scaling factor of 1.25 (±3%). Despite this, there was an improvement in the precision of the cross section measurement compared to values reported by the only previous study.Significance. Short-lived12N imaging is promising for real-timein vivoverification of the proton range to reduce clinical complications in proton therapy. The verification procedure requires experimental knowledge of the12N production cross section for proton energies of clinical importance, to be incorporated in a Monte Carlo framework for12N imaging prediction. This study is the first to achieve a precise measurement of the12C(p,n)12N nuclear cross section for such proton energies.