Pesquisa | Portal de Pesquisa da BVS

1.

Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins.

Ziegler, David S; Wright, Renee D; Kesari, Santosh; Lemieux, Madeleine E; Tran, Mary A; Jain, Monish; Zawel, Leigh; Kung, Andrew L.

J Clin Invest ; 118(9): 3109-22, 2008 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-18677408

2.

Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells.

Weisberg, Ellen; Kung, Andrew L; Wright, Renee D; Moreno, Daisy; Catley, Laurie; Ray, Arghya; Zawel, Leigh; Tran, Mary; Cools, Jan; Gilliland, Gary; Mitsiades, Constantine; McMillin, Douglas W; Jiang, Jingrui; Hall-Meyers, Elizabeth; Griffin, James D.

Mol Cancer Ther ; 6(7): 1951-61, 2007 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-17620426

3.

Dissecting Therapeutic Resistance to ERK Inhibition.

Jha, Sharda; Morris, Erick J; Hruza, Alan; Mansueto, My Sam; Schroeder, Gottfried K; Arbanas, Jaren; McMasters, Daniel; Restaino, Clifford R; Dayananth, Priya; Black, Stuart; Elsen, Nathaniel L; Mannarino, Anthony; Cooper, Alan; Fawell, Stephen; Zawel, Leigh; Jayaraman, Lata; Samatar, Ahmed A.

Mol Cancer Ther ; 15(4): 548-59, 2016 04.

Artigo em Inglês | MEDLINE | ID: mdl-26832798

4.

Novel Anti-TM4SF1 Antibody-Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature.

Visintin, Alberto; Knowlton, Kelly; Tyminski, Edyta; Lin, Chi-Iou; Zheng, Xiang; Marquette, Kimberly; Jain, Sadhana; Tchistiakova, Lioudmila; Li, Dan; O'Donnell, Christopher J; Maderna, Andreas; Cao, Xianjun; Dunn, Robert; Snyder, William B; Abraham, Anson K; Leal, Mauricio; Shetty, Shoba; Barry, Anthony; Zawel, Leigh; Coyle, Anthony J; Dvorak, Harold F; Jaminet, Shou-Ching.

Mol Cancer Ther ; 14(8): 1868-76, 2015 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-26089370

5.

Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma.

Stoeck, Alexander; Lejnine, Serguei; Truong, Andrew; Pan, Li; Wang, Hongfang; Zang, Chongzhi; Yuan, Jing; Ware, Chris; MacLean, John; Garrett-Engele, Philip W; Kluk, Michael; Laskey, Jason; Haines, Brian B; Moskaluk, Christopher; Zawel, Leigh; Fawell, Stephen; Gilliland, Gary; Zhang, Theresa; Kremer, Brandon E; Knoechel, Birgit; Bernstein, Bradley E; Pear, Warren S; Liu, X Shirley; Aster, Jon C; Sathyanarayanan, Sriram.

Cancer Discov ; 4(10): 1154-67, 2014 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-25104330

6.

Evaluating TBK1 as a therapeutic target in cancers with activated IRF3.

Muvaffak, Asli; Pan, Qi; Yan, Haiyan; Fernandez, Rafael; Lim, Jongwon; Dolinski, Brian; Nguyen, Thi T; Strack, Peter; Wu, Stephen; Chung, Rossana; Zhang, Weiqun; Hulton, Chris; Ripley, Steven; Hirsch, Heather; Nagashima, Kumiko; Wong, Kwok-Kin; Jánne, Pasi A; Seidel-Dugan, Cynthia; Zawel, Leigh; Kirschmeier, Paul T; Middleton, Richard E; Morris, Erick J; Wang, Yan.

Mol Cancer Res ; 12(7): 1055-66, 2014 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-24752990

7.

MCL1 and BCL-xL levels in solid tumors are predictive of dinaciclib-induced apoptosis.

Booher, Robert N; Hatch, Harold; Dolinski, Brian M; Nguyen, Thi; Harmonay, Lauren; Al-Assaad, Ali-Samer; Ayers, Mark; Nebozhyn, Michael; Loboda, Andrey; Hirsch, Heather A; Zhang, Theresa; Shi, Bin; Merkel, Carrie E; Angagaw, Minilik H; Wang, Yaolin; Long, Brian J; Lennon, Xianlu Q; Miselis, Nathan; Pucci, Vincenzo; Monahan, James W; Lee, Junghoon; Kondic, Anna Georgieva; Im, Eun Kyung; Mauro, David; Blanchard, Rebecca; Gilliland, Gary; Fawell, Stephen E; Zawel, Leigh; Schuller, Alwin G; Strack, Peter.

PLoS One ; 9(10): e108371, 2014.

Artigo em Inglês | MEDLINE | ID: mdl-25289887

8.

Preclinical evaluation of the WEE1 inhibitor MK-1775 as single-agent anticancer therapy.

Guertin, Amy D; Li, Jing; Liu, Yaping; Hurd, Melissa S; Schuller, Alwin G; Long, Brian; Hirsch, Heather A; Feldman, Igor; Benita, Yair; Toniatti, Carlo; Zawel, Leigh; Fawell, Stephen E; Gilliland, D Gary; Shumway, Stuart D.

Mol Cancer Ther ; 12(8): 1442-52, 2013 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-23699655

9.

Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.

Morris, Erick J; Jha, Sharda; Restaino, Clifford R; Dayananth, Priya; Zhu, Hugh; Cooper, Alan; Carr, Donna; Deng, Yongi; Jin, Weihong; Black, Stuart; Long, Brian; Liu, Jenny; Dinunzio, Edward; Windsor, William; Zhang, Rumin; Zhao, Shuxia; Angagaw, Minilik H; Pinheiro, Elaine M; Desai, Jagdish; Xiao, Li; Shipps, Gerald; Hruza, Alan; Wang, James; Kelly, Joe; Paliwal, Sunil; Gao, Xiaolei; Babu, Boga Sobhana; Zhu, Liang; Daublain, Pierre; Zhang, Ling; Lutterbach, Bart A; Pelletier, Marc R; Philippar, Ulrike; Siliphaivanh, Phieng; Witter, David; Kirschmeier, Paul; Bishop, W Robert; Hicklin, Daniel; Gilliland, D Gary; Jayaraman, Lata; Zawel, Leigh; Fawell, Stephen; Samatar, Ahmed A.

Cancer Discov ; 3(7): 742-50, 2013 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-23614898

10.

Evidence of mTOR Activation by an AKT-Independent Mechanism Provides Support for the Combined Treatment of PTEN-Deficient Prostate Tumors with mTOR and AKT Inhibitors.

Zhang, Weisheng; Haines, Brian B; Efferson, Clay; Zhu, Joe; Ware, Chris; Kunii, Kaiko; Tammam, Jennifer; Angagaw, Minilik; Hinton, Marlene C; Keilhack, Heike; Paweletz, Cloud P; Zhang, Theresa; Winter, Chris; Sathyanarayanan, Sriram; Cheng, Jonathan; Zawel, Leigh; Fawell, Stephen; Gilliland, Gary; Majumder, Pradip K.

Transl Oncol ; 5(6): 422-9, 2012 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-23323157

11.

A small-molecule IAP inhibitor overcomes resistance to cytotoxic therapies in malignant gliomas in vitro and in vivo.

Ziegler, David S; Keating, Joanna; Kesari, Santosh; Fast, Eva M; Zawel, Leigh; Ramakrishna, Naren; Barnes, Jessica; Kieran, Mark W; Veldhuijzen van Zanten, Sophie E M; Kung, Andrew L.

Neuro Oncol ; 13(8): 820-9, 2011 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-21724651

12.

IAP inhibitors enhance co-stimulation to promote tumor immunity.

Dougan, Michael; Dougan, Stephanie; Slisz, Joanna; Firestone, Brant; Vanneman, Matthew; Draganov, Dobrin; Goyal, Girija; Li, Weibo; Neuberg, Donna; Blumberg, Richard; Hacohen, Nir; Porter, Dale; Zawel, Leigh; Dranoff, Glenn.

J Exp Med ; 207(10): 2195-206, 2010 Sep 27.

Artigo em Inglês | MEDLINE | ID: mdl-20837698

13.

A histone deacetylase inhibitor LBH589 downregulates XIAP in mesothelioma cell lines which is likely responsible for increased apoptosis with TRAIL.

Symanowski, James; Vogelzang, Nicholas; Zawel, Leigh; Atadja, Peter; Pass, Harvey; Sharma, Sunil.

J Thorac Oncol ; 4(2): 149-60, 2009 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-19179889

14.

A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling.

Gaither, Alex; Porter, Dale; Yao, Yao; Borawski, Jason; Yang, Guang; Donovan, Jerry; Sage, David; Slisz, Joanna; Tran, Mary; Straub, Christopher; Ramsey, Tim; Iourgenko, Vadim; Huang, Alan; Chen, Yan; Schlegel, Robert; Labow, Mark; Fawell, Stephen; Sellers, William R; Zawel, Leigh.

Cancer Res ; 67(24): 11493-8, 2007 Dec 15.

Artigo em Inglês | MEDLINE | ID: mdl-18089776

15.

Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM).

Chauhan, Dharminder; Neri, Paola; Velankar, Mugdha; Podar, Klaus; Hideshima, Teru; Fulciniti, Mariateresa; Tassone, Pierfrancesco; Raje, Noopur; Mitsiades, Constantine; Mitsiades, Nicholas; Richardson, Paul; Zawel, Leigh; Tran, Mary; Munshi, Nikhil; Anderson, Kenneth C.

Blood ; 109(3): 1220-7, 2007 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-17032924

16.

Development of Peptidomimetics Targeting IAPs.

Sharma, Sushil K; Straub, Christopher; Zawel, Leigh.

Int J Pept Res Ther ; 12(1): 21-32, 2006 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-19617919

17.

P3Kα: a driver of tumor metastasis?

Zawel, Leigh.

Oncotarget ; 1(5): 315-6, 2010 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-21307397

18.

Teaching cancer cells to die.

Zawel, Leigh.

J Cell Biochem ; 92(4): 651-5, 2004 Jul 01.

Artigo em Inglês | MEDLINE | ID: mdl-15211563

19.

DEC1 is a downstream target of TGF-beta with sequence-specific transcriptional repressor activities.

Zawel, Leigh; Yu, Jian; Torrance, Christopher J; Markowitz, Sanford; Kinzler, Kenneth W; Vogelstein, Bert; Zhou, Shibin.

Proc Natl Acad Sci U S A ; 99(5): 2848-53, 2002 Mar 05.

Artigo em Inglês | MEDLINE | ID: mdl-11880636

Portal de Pesquisa da BVS

Informação e Conhecimento para a Saúde

Configurar filtros

Sua seleção (0)

Formato de exportação:

Exportar: