Detalhe da pesquisa
1.
Nmnat restores neuronal integrity by neutralizing mutant Huntingtin aggregate-induced progressive toxicity.
Proc Natl Acad Sci U S A
; 116(38): 19165-19175, 2019 09 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31484760
2.
Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss.
Proc Natl Acad Sci U S A
; 116(4): 1347-1352, 2019 01 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30610177
3.
Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLD(S)-mediated axon protection independent of axonal mitochondria.
Hum Mol Genet
; 22(8): 1601-14, 2013 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23314018
4.
Nicotinamide mononucleotide adenylyltransferase maintains active zone structure by stabilizing Bruchpilot.
EMBO Rep
; 14(1): 87-94, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23154466
5.
NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy.
Hum Mol Genet
; 21(2): 237-50, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21965302
6.
CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy.
Hum Mol Genet
; 21(2): 251-67, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22027994
7.
NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.
Nature
; 452(7189): 887-91, 2008 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-18344983
8.
The role of autophagy in Nmnat-mediated protection against hypoxia-induced dendrite degeneration.
Mol Cell Neurosci
; 52: 140-51, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23159780
9.
High-resolution, high-throughput analysis of Drosophila geotactic behavior.
bioRxiv
; 2024 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38895419
10.
Copper enhances aggregational toxicity of mutant huntingtin in a Drosophila model of Huntington's Disease.
Biochim Biophys Acta Mol Basis Dis
; 1870(1): 166928, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38660915
11.
Reduction of spermine synthase enhances autophagy to suppress Tau accumulation.
Cell Death Dis
; 15(5): 333, 2024 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38740758
12.
Protein aggregates are recruited to aggresome by histone deacetylase 6 via unanchored ubiquitin C termini.
J Biol Chem
; 287(4): 2317-27, 2012 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22069321
13.
The Architecture of the Presynaptic Release Site.
Adv Neurobiol
; 33: 1-21, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37615861
14.
Presynaptic Cytomatrix Proteins.
Adv Neurobiol
; 33: 23-42, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37615862
15.
MicroRNA-Mediated Obstruction of Stem-loop Alternative Splicing (MIMOSAS): a global mechanism for the regulation of alternative splicing.
bioRxiv
; 2023 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37425843
16.
Reduction of Spermine Synthase Suppresses Tau Accumulation Through Autophagy Modulation in Tauopathy.
bioRxiv
; 2023 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36993333
17.
Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder-Robinson syndrome.
EMBO Mol Med
; 15(11): e17833, 2023 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37702369
18.
Sorbitol reduction via govorestat ameliorates synaptic dysfunction and neurodegeneration in sorbitol dehydrogenase deficiency.
JCI Insight
; 8(10)2023 05 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37014713
19.
Nicotinamide mononucleotide adenylyltransferase is a stress response protein regulated by the heat shock factor/hypoxia-inducible factor 1alpha pathway.
J Biol Chem
; 286(21): 19089-99, 2011 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21478149
20.
Nmnat exerts neuroprotective effects in dendrites and axons.
Mol Cell Neurosci
; 48(1): 1-8, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21596138