1.
Org Lett
; 16(24): 6472-5, 2014 Dec 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25487704
RESUMO
This work describes an efficient α-alkylation reaction of α-amino aldehydes with 3-indolylmethanols. In the promotion of catalyst 3f, the target products were obtained in high yields (up to 99%), good diastereoselectivities (up to 88:12), and excellent enantioselectivities (up to 96% ee). The direct alkylation products can be readily converted into other tryptophan derivatives without the loss of stereoselectivities.