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Normal spinel zinc ferrite (ZnFe2O4) nanoparticles (NPs) with zero net magnetization were synthesized by a facile coprecipitation method in which two kinds of organic alkali, namely, 1-amino-2-propanol (MIPA) and bis(2-hydroxypropyl)-amine (DIPA), were used. The diameters of the ZnFe2O4 NPs were determined to be about 7 and 9 nm for samples prepared with MIPA and DIPA, respectively, and the normal spinel structure was confirmed by the magnetic property measurement at room temperature and the temperature dependence of the direct current magnetization. These results are different from those reported in the literature, where ZnFe2O4 NPs show a nonzero net magnetization. The heat capacity of the ZnFe2O4 NPs synthesized using DIPA was measured using a physical property measurement system in the temperature range from 2 to 300 K, and the thermodynamic functions were calculated based on the curve fitting of the experimental heat capacity data. The heat capacity of the ZnFe2O4 NPs was compared with that of a nanosized (Zn(0.795)Fe(0.205))[Zn(0.205)Fe(1.795)]O4 material studied in the literature, indicating that the Debye temperature of the present sample is more comparable with that of the bulk ZnFe2O4 reported by Westrum et al.
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In solving specific problems, physical laws and mathematical theorems directly express the connections between variables with equations/inequations. At times, it could be extremely hard or not viable to solve these equations/inequations directly. The PE (principle of equivalence) is a commonly applied pragmatic method across multiple fields. PE transforms the initial equations/inequations into simplified equivalent equations/inequations that are more manageable to solve, allowing researchers to achieve their objectives. The problem-solving process in many fields benefits from the use of PE. Recently, the ZE (Zhang equivalency) framework has surfaced as a promising approach for addressing time-dependent optimization problems. This ZEF (ZE framework) consolidates constraints at different tiers, demonstrating its capacity for the solving of time-dependent optimization problems. To broaden the application of ZEF in time-dependent optimization problems, specifically in the domain of motion planning for redundant manipulators, the authors systematically investigate the ZEF-I2I (ZEF of the inequation-to-inequation) type. The study concentrates on transforming constraints (i.e., joint constraints and obstacles avoidance depicted in different tiers) into consolidated constraints backed by rigorous mathematical derivations. The effectiveness and applicability of the ZEF-I2I are verified through two optimization motion planning schemes, which consolidate constraints in the velocity-tier and acceleration-tier. Schemes are required to accomplish the goal of repetitive motion planning within constraints. The firstly presented optimization motion planning schemes are then reformulated as two time-dependent quadratic programming problems. Simulative experiments conducted on the basis of a six-joint redundant manipulator confirm the outstanding effectiveness of the firstly presented ZEF-I2I in achieving the goal of motion planning within constraints.
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To obtain smoother kinematic control of minimum motion, a novel snap-layer minimum motion scheme, otherwise known as the minimum motion planning and control (MMPC) scheme for redundant robot arms, is proposed for the first time in this study. With the primary task of tracking planned paths and the consideration of satisfying five-layer physical limits, the snap-layer MMPC problem is transformed into a quadratic programming (QP) problem. Five-layer physical limits include angle-layer, velocity-layer, acceleration-layer, jerk-layer, and snap-layer limits, which are all considered and then transformed into a unified-layer bounded constraint through Zhang neural dynamics (ZND) equivalency. Furthermore, the snap-layer performance index and equation constraint are derived by utilizing the ZND formula. Therefore, the proposed snap-layer MMPC scheme is formulated as a standard QP that can avoid the potential physical damage of redundant robot arms. The snap-layer projection neural dynamics (PND) solver is presented and used to acquire the neural solution of the QP. Simulation results on a 6-degrees-of-freedom (DOF) planar redundant robot arm are presented to substantiate the effectiveness and superiority of the proposed snap-layer MMPC scheme by comparing it with the jerk-layer MMPC scheme and the minimum snap norm (MSN) scheme.
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Conventional electrochemical sensors use voltammetric and amperometric methods with external power supply and modulation systems, which hinder the flexibility and application of the sensors. To avoid the use of an external power system and to minimize the number of electrochemical cell components, a self-powered electrochemical sensor (SPES) for hydrogen peroxide was investigated here. Iron phthalocyanine, an enzyme mimetic material, and Ni were used as a cathode catalyst and an anode material, respectively. The properties of the iron phthalocyanine catalyst modified by graphene nanoplatelets (GNPs) were investigated. Open circuit potential tests demonstrated the feasibility of this system. The GNP-modulated interface helped to solve the problems of aggregation and poor conductivity of iron phthalocyanine and allowed for the achievement of the best analytical characteristics of the self-powered H2O2 sensor with a low detection limit of 0.6 µM and significantly higher sensitivity of 0.198 A/(M·cm2) due to the enhanced electrochemical properties. The SPES demonstrated the best performance at pH 3.0 compared to pH 7.4 and 12.0. The sensor characteristics under the control of external variable load resistances are discussed and the cell showed the highest power density of 65.9 µW/cm2 with a 20 kOhm resistor. The practical applicability of this method was verified by the determination of H2O2 in blood serum.
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Técnicas Biossensoriais , Técnicas Eletroquímicas , Eletrodos , Grafite , Peróxido de Hidrogênio , Grafite/química , Catálise , Indóis/química , Limite de Detecção , Compostos Ferrosos/química , Platina/química , Níquel/químicaRESUMO
Two innovative acceleration-layer configuration amendment (CA) schemes are proposed to achieve the CA of constrained redundant robot arms. Specifically, by applying the Zhang neurodynamics equivalency (ZNE) method, an acceleration-layer CA performance indicator is derived theoretically. To obtain a unified-layer inequality constraint by transforming from angle-layer and velocity-layer constraints to acceleration-layer constraints, five theorems and three corollaries are theoretically derived and rigorously proved. Then, together with the unified acceleration-layer bound constraint, an enhanced acceleration-layer CA scheme specially considering three-layer time-variant physical limits is proposed, and a simplified acceleration-layer CA scheme considering three-layer time-invariant physical limits is also proposed. The proposed CA schemes are finally formulated in the form of standard quadratic programming and are solved by a projection neurodynamics solver. Moreover, comparative simulative experiments based on a four-link planar arm and a UR3 spatial arm are performed to verify the efficacy and superiority of the proposed CA schemes. At last, physical experiments are conducted on a real Kinova Jaco2 arm to substantiate the practicability of the proposed CA schemes.
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In this paper, the problem of time-variant optimization subject to nonlinear equation constraint is studied. To solve the challenging problem, methods based on the neural networks, such as zeroing neural network and gradient neural network, are commonly adopted due to their performance on handling nonlinear problems. However, the traditional zeroing neural network algorithm requires computing the matrix inverse during the solving process, which is a complicated and time-consuming operation. Although the gradient neural network algorithm does not require computing the matrix inverse, its accuracy is not high enough. Therefore, a novel inverse-free zeroing neural network algorithm without matrix inverse is proposed in this paper. The proposed algorithm not only avoids the matrix inverse, but also avoids matrix multiplication, greatly reducing the computational complexity. In addition, detailed theoretical analyses of the convergence performance of the proposed algorithm is provided to guarantee its excellent capability in solving time-variant optimization problems. Numerical simulations and comparative experiments with traditional zeroing neural network and gradient neural network algorithms substantiate the accuracy and superiority of the novel inverse-free zeroing neural network algorithm. To further validate the performance of the novel inverse-free zeroing neural network algorithm in practical applications, path tracking tasks of three manipulators (i.e., Universal Robot 5, Franka Emika Panda, and Kinova JACO2 manipulators) are conducted, and the results verify the applicability of the proposed algorithm.
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While the handling for temporally-varying linear equation (TVLE) has received extensive attention, most methods focused on trading off the conflict between computational precision and convergence rate. Different from previous studies, this paper proposes two complete adaptive zeroing neural dynamics (ZND) schemes, including a novel adaptive continuous ZND (ACZND) model, two general variable time discretization techniques, and two resultant adaptive discrete ZND (ADZND) algorithms, to essentially eliminate the conflict. Specifically, an error-related varying-parameter ACZND model with global and exponential convergence is first designed and proposed. To further adapt to the digital hardware, two novel variable time discretization techniques are proposed to discretize the ACZND model into two ADZND algorithms. The convergence properties with respect to the convergence rate and precision of ADZND algorithms are proved via rigorous mathematical analyses. By comparing with the traditional discrete ZND (TDZND) algorithms, the superiority of ADZND algorithms in convergence rate and computational precision is shown theoretically and experimentally. Finally, simulative experiments, including numerical experiments on a specific TVLE solving as well as four application experiments on arm path following and target motion positioning are successfully conducted to substantiate the efficacy, superiority, and practicability of ADZND algorithms.
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Algoritmos , Braço , Simulação por Computador , Movimento (Física)RESUMO
In this article, being different from conventional time-discretization (simply called discretization) formulas, explicit linear left-and-right 5-step (ELLR5S) formulas with sixth-order precision are proposed. The general sixth-order ELLR5S formula with four variable parameters is developed first, and constraints of these four parameters are displayed to guarantee the zero stability, consistence, and convergence of the formula. Then, by choosing specific parameter values within constraints, eight specific sixth-order ELLR5S formulas are developed. The general sixth-order ELLR5S formula is further utilized to generate discrete zeroing neural network (DZNN) models for solving time-varying linear and nonlinear systems. For comparison, three conventional discretization formulas are also utilized. Theoretical analyses are presented to show the performance of ELLR5S formulas and DZNN models. Furthermore, abundant experiments, including three practical applications, that is, angle-of-arrival (AoA) localization and two redundant manipulators (PUMA560 manipulator and Kinova manipulator) control, are conducted. The synthesized results substantiate the efficacy and superiority of sixth-order ELLR5S formulas as well as the corresponding DZNN models.
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Equivalency is a powerful approach that can transform an original problem into another problem that is relatively more ready to be resolved. In recent years, Zhang neurodynamics equivalency (ZNE), in the form of neurodynamics or recurrent neural networks (RNNs), has been investigated, abstracted, and proposed as a process that can equivalently solve equations at different levels. After long-term research, we have noticed that the ZNE can not only work with equations, but also inequations. Thus, the ZNE of inequation type is proposed, proved, and applied in this study. The ZNE of inequation type can transform different-level bound constraints into unified-level bound constraints. Applications of the jerk-level ZNE of bound constraints, equation constraints, and objective indices ultimately build up effective time-varying quadratic-programming schemes for cyclic motion planning and control (CMPC) of single and dual robot-arm systems. In addition, as an effective time-varying quadratic-programming solver, a projection neural network (PNN) is introduced. Experimental results with single and dual robot-arm systems substantiate the correctness and efficacy of ZNE and especially the ZNE of inequation type. Comparisons with conventional methods also exhibit the superiorities of ZNE.
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By considering the different-level time-varying physical limits in joint space, a refined self-motion control scheme via Zhang neurodynamics equivalency (SMCSvZ) of redundant robot manipulators is proposed, analyzed, and investigated in this manuscript. The SMCSvZ is reformulated as a quadratic program with an equation constraint and a unified bound inequation constraint, which meets the self-motion requirements including the end effector keeping immobile and the initial joint-angle velocities being zero. Simulative verifications based on a six-degrees-of-freedom planar redundant manipulator substantiate the efficacy, accuracy, and superiority of the proposed control scheme, additionally by comparing it with two previous self-motion control schemes. Besides, simulative verifications based on a PUMA560 manipulator are carried out to further verify the availability and correctness of the SMCSvZ.
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To solve the time-variant Sylvester equation, in 2013, Li et al. proposed the zeroing neural network with sign-bi-power function (ZNN-SBPF) model via constructing a nonlinear activation function. In this article, to further improve the convergence rate, the zeroing neural network with coefficient functions and adjustable parameters (ZNN-CFAP) model as a variation in zeroing neural network (ZNN) model is proposed. On the basis of the introduced coefficient functions, an appropriate ZNN-CFAP model can be chosen according to the error function. The high convergence rate of the ZNN-CFAP model can be achieved by choosing appropriate adjustable parameters. Moreover, the finite-time convergence property and convergence time upper bound of the ZNN-CFAP model are proved in theory. Computer simulations and numerical experiments are performed to illustrate the efficacy and validity of the ZNN-CFAP model in time-variant Sylvester equation solving. Comparative experiments among the ZNN-CFAP, ZNN-SBPF, and ZNN with linear function (ZNN-LF) models further substantiate the superiority of the ZNN-CFAP model in view of the convergence rate. Finally, the proposed ZNN-CFAP model is successfully applied to the tracking control of robot manipulator to verify its practicability.
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Time-dependent linear system (TDLS) is usually encountered in scientific research, which is the mathematical formulation of many practical applications. Different from conventional inverse-need models, by utilizing zeroing neural network (ZNN) method twice, an inverse-free continuous ZNN (CZNN) model is developed for solving TDLS. For conveniently practical use, a discrete model is naturally desired. Superior to conventional discretization methods, a general linear six-step (LSS) method with the seventh-order precision and five variable parameters is proposed for the first time. Constraints about five variable parameters are theoretically analyzed to guarantee the efficacy of the general LSS method. Within constraints, 12 specific LSS methods are further developed. Aided with the general LSS method, an inverse-free discrete ZNN (DZNN) is proposed and termed DZNN-LSS model, and its precision is greatly improved compared with conventional discrete models. For comparison, three conventional discretization methods are also utilized to generate DZNN models. Detailed theoretical analyses are provided to prove the efficacy of relevant models. In addition, a specific TDLS example is considered to show the effectiveness and superiority of the DZNN-LSS model. More than that, applications to manipulator control and sound source localization are conducted to illustrate the applicability of the DZNN-LSS model.
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This research first proposes the general expression of Zhang et al. discretization (ZeaD) formulas to provide an effective general framework for finding various ZeaD formulas by the idea of high-order derivative simultaneous elimination. Then, to solve the problem of future equality-constrained nonlinear optimization (ECNO) with various noises, a specific ZeaD formula originating from the general ZeaD formula is further studied for the discretization of a noise-perturbed continuous-time advanced zeroing neurodynamic model. Subsequently, the resulting noise-perturbed discrete-time advanced zeroing neurodynamic (NP-DTAZN) algorithm is proposed for the real-time solution to the future ECNO problem with various noises suppressed simultaneously. Moreover, theoretical and numerical results are presented to show the convergence and precision of the proposed NP-DTAZN algorithm in the perturbation of various noises. Finally, comparative numerical and physical experiments based on a Kinova JACO2 robot manipulator are conducted to further substantiate the efficacy, superiority, and practicability of the proposed NP-DTAZN algorithm for solving the future ECNO problem with various noises.
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Algoritmos , Redes Neurais de Computação , Simulação por ComputadorRESUMO
Differing from the common linear matrix equation, the future different-level linear matrix system is considered, which is much more interesting and challenging. Because of its complicated structure and future-computation characteristic, traditional methods for static and same-level systems may not be effective on this occasion. For solving this difficult future different-level linear matrix system, the continuous different-level linear matrix system is first considered. On the basis of the zeroing neural network (ZNN), the physical mathematical equivalency is thus proposed, which is called ZNN equivalency (ZE), and it is compared with the traditional concept of mathematical equivalence. Then, on the basis of ZE, the continuous-time synthesis (CTS) model is further developed. To satisfy the future-computation requirement of the future different-level linear matrix system, the 7-instant discrete-time synthesis (DTS) model is further attained by utilizing the high-precision 7-instant Zhang et al. discretization (ZeaD) formula. For a comparison, three different DTS models using three conventional ZeaD formulas are also presented. Meanwhile, the efficacy of the 7-instant DTS model is testified by the theoretical analyses. Finally, experimental results verify the brilliant performance of the 7-instant DTS model in solving the future different-level linear matrix system.
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Redes Neurais de ComputaçãoRESUMO
The problem of solving linear equations is considered as one of the fundamental problems commonly encountered in science and engineering. In this article, the complex-valued time-varying linear matrix equation (CVTV-LME) problem is investigated. Then, by employing a complex-valued, time-varying QR (CVTVQR) decomposition, the zeroing neural network (ZNN) method, equivalent transformations, Kronecker product, and vectorization techniques, we propose and study a CVTVQR decomposition-based linear matrix equation (CVTVQR-LME) model. In addition to the usage of the QR decomposition, the further advantage of the CVTVQR-LME model is reflected in the fact that it can handle a linear system with square or rectangular coefficient matrix in both the matrix and vector cases. Its efficacy in solving the CVTV-LME problems have been tested in a variety of numerical simulations as well as in two applications, one in robotic motion tracking and the other in angle-of-arrival localization.
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This study investigates the intrinsic multienzyme-like properties of the non-stabilized nanocrystalline nanoparticles of manganese-doped Prussian blue (Mn-PB) nanozymes and Prussian blue (PB) nanozymes in chemical and electrocatalytic transformations of reactive oxygen species. The effect of manganese doping on the structural, biomimetic, and electrocatalytic properties of cyano-bridged assemblies is also discussed.
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REarranged during Transfection (RET) is a validated target for anticancer drug discovery and two selective RET inhibitors were approved by US FDA in 2020. However, acquired resistance mediated by secondary mutations in the solvent-front region of the kinase (e.g. G810C/S/R) becomes a major challenge for selective RET inhibitor therapies. Herein, we report a structure-based design of 1-methyl-3-((4-(quinolin-4-yloxy)phenyl)amino)-1H-pyrazole-4-carboxamide derivatives as new RET kinase inhibitors which are capable of suppressing the RETG810 C/R resistant mutants. One of the representative compounds, 8q, potently suppressed wild-type RET kinase with an IC50 value of 13.7 nM. It also strongly inhibited the proliferation of BaF3 cells stably expressing various oncogenic fusions of RET kinase with solvent-front mutations, e.g. CCDC6-RETG810C, CCDC6-RETG810R, KIF5B-RETG810C and KIF5B-RETG810R, with IC50 values of 15.4, 53.2, 54.2 and 120.0 nM, respectively. Furthermore, 8q dose-dependently inhibited the activation of RET and downstream signals and obviously triggered apoptosis in Ba/F3-CCDC6-RETG810 C/R cells. The compound also exhibited significant anti-tumor efficacy with a tumor growth inhibition (TGI) value of 66.9% at 30 mg/kg/day via i. p. in a Ba/F3-CCDC6-RETG810C xenograft mouse model. Compound 8q may be utilized as a lead compound for drug discovery combating acquired resistance against selective RET inhibitor therapies.
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Neoplasias Pulmonares , Proteínas Proto-Oncogênicas c-ret , Humanos , Camundongos , Animais , Solventes , Linhagem Celular Tumoral , Inibidores de Proteínas Quinases/farmacologia , Inibidores de Proteínas Quinases/uso terapêutico , Pirazóis/farmacologia , Pirazóis/uso terapêutico , Mutação , Transfecção , Neoplasias Pulmonares/tratamento farmacológicoRESUMO
The receptor tyrosine kinase AXL is a promising target for anticancer drug discovery. Herein, we describe the discovery of 3-aminopyrazole derivatives as new potent and selective AXL kinase inhibitors. One of the representative compounds, 6li, potently inhibited AXL enzymatic activity with an IC50 value of 1.6 nM, and tightly bound with AXL protein with a Kd value of 0.26 nM, while was obviously less potent against most of the 403 wild-type kinases evaluated. Cell-based assays demonstrated that compound 6li potently inhibited AXL signaling, suppressed Ba/F3-TEL-AXL cell proliferation, reversed TGF-ß1-induced epithelial-mesenchymal transition, and dose-dependently impeded cancer cell migration and invasion. Compound 6li also showed reasonable pharmacokinetic properties in rats and exhibited significant in vivo antitumor efficacy in a xenograft model of highly metastatic murine breast cancer 4T1 cells. Taken together, this study provides a new potent and selective AXL inhibitor for further anticancer drug discovery.
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Antineoplásicos , Inibidores de Proteínas Quinases , Receptores Proteína Tirosina Quinases , Animais , Feminino , Humanos , Camundongos , Ratos , Antineoplásicos/farmacologia , Antineoplásicos/uso terapêutico , Neoplasias da Mama/tratamento farmacológico , Linhagem Celular Tumoral , Proliferação de Células , Inibidores de Proteínas Quinases/uso terapêutico , Inibidores de Proteínas Quinases/farmacocinética , Pirazóis/farmacologia , Pirazóis/uso terapêutico , Ensaios Antitumorais Modelo de Xenoenxerto , Receptores Proteína Tirosina Quinases/antagonistas & inibidores , Receptor Tirosina Quinase AxlRESUMO
Time-varying matrix pseudoinverse (TVMP) problem has been investigated by many researchers in recent years, but a new class of matrix termed Zhang matrix has been found and not been handled by some conventional models, e.g., Getz-Marsden dynamic model. On the other way, future matrix pseudoinverse (FMP), as a more challenging and intractable discrete-time problem, deserves more attention due to its significant role-playing on some engineering applications, such as redundant manipulator. Based on the zeroing neural network (ZNN), this article concentrates on designing new discrete ZNN models appropriately for computing the FMPs of all matrices of full rank, including the Zhang matrix. First, an inverse-free continuous ZNN model for computing TVMP is derived. Subsequently, Zhang et al. discretization (ZeaD) formulas and equidistant extrapolation formulas are used to discretize the continuous ZNN model to two discrete ZNN models for computing FMPs with different truncation errors. The numerical experiments are conducted for the five conventional discrete models and two new discrete ZNN models. Distinct numerical results substantiate the effectiveness and choiceness of newly proposed models. Finally, one of the newly proposed models is implemented on simulating and physical instances of robot manipulators, respectively, to show its practicability.
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In this article, a novel and challenging problem called future different-level system of nonlinear inequality and linear equation (FDLSNILE) is proposed and investigated. To solve FDLSNILE, the corresponding continuous different-level system of nonlinear inequality and linear equation (CDLSNILE) is first analyzed, and then, a continuous combined zeroing neural network (CCZNN) model for solving CDLSNILE is proposed. To obtain a discrete combined zeroing neural network (DCZNN) model for solving FDLSNILE, a high-precision general 7-instant Zhang et al. discretization (ZeaD) formula for the first-order time derivative approximation is proposed. Furthermore, by applying the general 7-instant ZeaD formula to discretize the CCZNN model, a general 7-instant DCZNN (7IDCZNN) model is thus proposed for solving FDLSNILE. For comparison, by using three conventional ZeaD formulas, three conventional DCZNN models are also developed. Meanwhile, theoretical analyses and results guarantee the efficacy and superiority of the general 7IDCZNN model compared with the other three conventional DCZNN models for solving FDLSNILE. Finally, several comparative numerical experiments, including the motion control of a 5-link redundant manipulator, are provided to substantiate the efficacy and superiority of the general 7-instant ZeaD formula and the corresponding 7IDCZNN model.