Detalhe da pesquisa
1.
Optimization of the synthesis of BET BD2 selective inhibitor XY153.
Chem Biodivers
; 21(2): e202301584, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38163253
2.
Construction of Diversified Penta-Spiro-Heterocyclic and Fused-Heterocyclic Frameworks with Potent Antitumor Activity.
Chemistry
; 29(54): e202301553, 2023 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37370192
3.
Construction of Diversified Penta-Spiro-Heterocyclic and Fused-Heterocyclic Frameworks with Potent Antitumor Activity.
Chemistry
; 29(54): e202302677, 2023 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37732554
4.
Rational design, synthesis and biological evaluation of benzo[d]isoxazole derivatives as potent BET bivalent inhibitors for potential treatment of prostate cancer.
Bioorg Chem
; 135: 106495, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37004437
5.
Discovery and structure-activity relationship studies of novel Bcl-2/Mcl-1 dual inhibitors with indole scaffold.
Bioorg Chem
; 125: 105845, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35512494
6.
Development of a series of novel Mcl-1 inhibitors bearing an indole carboxylic acid moiety.
Bioorg Chem
; 127: 106018, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35901526
7.
Synthesis of Paclitaxel Derivatives for Remote Loading into Liposomes and Improved Therapeutic Effect.
Molecules
; 27(22)2022 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36432067
8.
Design, synthesis and biological evaluation of dual Bcl-2/Mcl-1 inhibitors bearing 2-(1H-indol-4-yl)benzoic acid scaffold.
Bioorg Med Chem Lett
; 47: 128215, 2021 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34153472
9.
Design, synthesis and biological evaluation of selective histone deacetylase 6 (HDAC6) inhibitors bearing benzoindazole or pyrazoloindazole scaffold as surface recognition motif.
Bioorg Chem
; 111: 104910, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33894432
10.
Synthesis and antitumor effects of novel 18ß-glycyrrhetinic acid derivatives featuring an exocyclic α,ß-unsaturated carbonyl moiety in ring A.
Bioorg Chem
; 103: 104187, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32890994
11.
Design, Synthesis and Bioactivity Evaluation of 4,6-Disubstituted Pyrido[3,2-d]pyrimidine Derivatives as Mnk and HDAC Inhibitors.
Molecules
; 25(18)2020 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32967084
12.
Design, synthesis and biological evaluation of benzimidazole derivatives as novel human Pin1 inhibitors.
Bioorg Med Chem Lett
; 29(14): 1859-1863, 2019 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31103446
13.
Design, synthesis and biological evaluation of novel indole derivatives as potential HDAC/BRD4 dual inhibitors and anti-leukemia agents.
Bioorg Chem
; 84: 410-417, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30554080
14.
Discovery of novel (+)-Usnic acid derivatives as potential anti-leukemia agents with pan-Pim kinases inhibitory activity.
Bioorg Chem
; 89: 102971, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31200288
15.
Structure-Based Design of Novel Benzimidazole Derivatives as Pin1 Inhibitors.
Molecules
; 24(7)2019 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30934730
16.
Design, synthesis and biological evaluation of ring A modified 11-keto-boswellic acid derivatives as Pin1 inhibitors with remarkable anti-prostate cancer activity.
Bioorg Med Chem Lett
; 28(19): 3187-3193, 2018 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30153964
17.
Design, synthesis and biological evaluation of novel hydroxamic acid based histone deacetylase 6 selective inhibitors bearing phenylpyrazol scaffold as surface recognition motif.
Bioorg Med Chem
; 26(8): 1418-1425, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29500130
18.
Design and synthesis of novel 6-hydroxy-4-methoxy-3-methylbenzofuran-7-carboxamide derivatives as potent Mnks inhibitors by fragment-based drug design.
Bioorg Med Chem
; 26(16): 4602-4614, 2018 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30115493
19.
[Design, synthesis and antiproliferative activity in cancer cells of novel dihydropyrazolyl and pyrazolyl artemisinin-phenyl ethers].
Zhongguo Zhong Yao Za Zhi
; 43(17): 3582-3588, 2018 Sep.
Artigo
em Chinês
| MEDLINE | ID: mdl-30347929
20.
Discovery and structure-activity relationship studies of N-substituted indole derivatives as novel Mcl-1 inhibitors.
Bioorg Med Chem Lett
; 27(9): 1943-1948, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28343875