RESUMO
OBJECTIVE: To explore the distribution characteristics of main antigen gene frequencies of Duffy,Diego,Kidd,Dombrock,MNS,Lutheran,Kell,Colton,Scianna,Yt,Knops and Indian in red blood cell blood group system of Li nationality in Hainan Province. METHODS: Antigens in twelve rare blood group systems of 214 Li people in Hainan Province were genotyped and analyzed by polymerase chain reaction-sequence specific primers (PCR-SSP). RESULTS: The gene frequency of antigens in twelve rare blood group systems of 214 Li people in Hainan Province including: the gene frequency of Duffy blood group system: fya=0.9556ï¼fyb=0.0444ï¼the gene frequency of Diego blood group system: Dia=0.0678ï¼Dib=0.9322ï¼the gene frequency of Kidd blood group systemï¼JKa=0.4533ï¼JKb=0.5467ï¼the gene frequency of Dombrock blood group systemï¼DOa=0.1051ï¼DOb=0.8949ï¼the gene frequency of MNS blood group systemï¼M=0.8131ï¼N=0.1869,S=0.0327ï¼s=0.9673ï¼Mur+=0.5748ï¼Mur-=0.4252ï¼the gene frequency of Lutheran blood group systemï¼AUa=0.8318ï¼AUb=0.1682ï¼the Kell, Colton, Scianna, Yt, Knops and Indian blood type systems showed a monomorph and the genotype was kk, coacoa, Sc1Sc1, YtaYta, KnaKna and InbInb. The observed and expected genotype values in twelve rare blood group systems of Li nationality in Hainan province were obeyed by the Hardy-Weinberg genitic rules. The difference between the observed and expectated values of the Kidd blood group system showed significant differencesï¼χ2=17.1946ï¼P=0.0002ï¼. CONCLUSION: The genetic distribution and genetic status in twelve rare blood group systems of Li nationality in Hainan Province are relatively stable. The gene distribution of Duffy, Diego, Kidd, Drombrock, MNS and Lutheran blood group systems are polymorphic and show unique distribution characteristics compared with other regions and different nationalities. The gene frequency distribution of KellãColtonãSciannaãYtãKnopsãIndian blood group systems are monomorphic.