Detalhe da pesquisa
1.
Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability.
Bioorg Med Chem Lett
; 26(2): 575-579, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26675441
2.
Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834.
Bioorg Med Chem Lett
; 25(6): 1333-7, 2015 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25701252
3.
Necrostatin-1, RIP1/RIP3 inhibitor, relieves transforming growth factor ß-induced wound-healing process in formation of hypertrophic scars.
J Cosmet Dermatol
; 20(8): 2612-2618, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-33237588
4.
Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases.
ACS Med Chem Lett
; 11(4): 506-513, 2020 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32292557
5.
Anionic Indole N-carbamoyl N --> C translocation. A directed remote metalation route to 2-Aryl- and 2-heteroarylindoles. synthesis of benz[a]carbazoles and Indeno[1,2-b]indoles.
Org Lett
; 10(13): 2617-20, 2008 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-18543941
6.
Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties.
ACS Med Chem Lett
; 8(6): 608-613, 2017 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28626519
7.
Directed ortho metalation-based methodology. Halo-, nitroso-, and boro-induced ipso-desilylation. Link to an in situ Suzuki reaction.
Org Lett
; 7(13): 2523-6, 2005 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-15957881
8.
Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase.
J Med Chem
; 57(9): 3856-73, 2014 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24779514