Detalhe da pesquisa
1.
The classical D1 dopamine receptor antagonist SCH23390 is a functional sigma-1 receptor allosteric modulator.
Acta Pharmacol Sin
; 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38605179
2.
Dynamic regulation of excitatory and inhibitory synaptic transmission by growth hormone in the developing mouse brain.
Acta Pharmacol Sin
; 44(6): 1109-1121, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-36476808
3.
Structural optimizations and bioevaluation of N-H aporphine analogues as Gq-biased and selective serotonin 5-HT2C receptor agonists.
Bioorg Chem
; 123: 105795, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35430417
4.
Discovery of novel MIF inhibitors that attenuate microglial inflammatory activation by structures-based virtual screening and in vitro bioassays.
Acta Pharmacol Sin
; 43(6): 1508-1520, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-34429524
5.
Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice.
Acta Pharmacol Sin
; 43(7): 1686-1698, 2022 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-34811513
6.
Glycoproteins as diagnostic and prognostic biomarkers for neurodegenerative diseases: A glycoproteomic approach.
J Neurosci Res
; 99(5): 1308-1324, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33634546
7.
Absence of TRIM32 Leads to Reduced GABAergic Interneuron Generation and Autism-like Behaviors in Mice via Suppressing mTOR Signaling.
Cereb Cortex
; 30(5): 3240-3258, 2020 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31828304
8.
Development and characterization of an inducible Dicer conditional knockout mouse model of Parkinson's disease: validation of the antiparkinsonian effects of a sigma-1 receptor agonist and dihydromyricetin.
Acta Pharmacol Sin
; 41(4): 499-507, 2020 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-32112040
9.
The oncometabolite 2-hydroxyglutarate inhibits microglial activation via the AMPK/mTOR/NF-κB pathway.
Acta Pharmacol Sin
; 40(10): 1292-1302, 2019 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-31015738
10.
Activation of Nur77 in microglia attenuates proinflammatory mediators production and protects dopaminergic neurons from inflammation-induced cell death.
J Neurochem
; 140(4): 589-604, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27889907
11.
Mutation of SLC35D3 causes metabolic syndrome by impairing dopamine signaling in striatal D1 neurons.
PLoS Genet
; 10(2): e1004124, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24550737
12.
Dihydromyricetin protects neurons in an MPTP-induced model of Parkinson's disease by suppressing glycogen synthase kinase-3 beta activity.
Acta Pharmacol Sin
; 37(10): 1315-1324, 2016 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27374489
13.
Emerging novel approaches to drug research and diagnosis of Parkinson's disease.
Acta Pharmacol Sin
; 41(4): 439-441, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32203079
14.
Protease Omi facilitates neurite outgrowth in mouse neuroblastoma N2a cells by cleaving transcription factor E2F1.
Acta Pharmacol Sin
; 36(8): 966-75, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26238290
15.
Synthesis of 5α-cholestan-6-one derivatives and their inhibitory activities of NO production in activated microglia: discovery of a novel neuroinflammation inhibitor.
Bioorg Med Chem Lett
; 24(4): 1222-7, 2014 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24456901
16.
Effects of SKF83959 on the excitability of hippocampal CA1 pyramidal neurons: a modeling study.
Acta Pharmacol Sin
; 35(6): 738-51, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24858313
17.
SKF83959 is a novel triple reuptake inhibitor that elicits anti-depressant activity.
Acta Pharmacol Sin
; 34(9): 1149-55, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23892272
18.
l-Stepholidine-induced excitation of dopamine neurons in rat ventral tegmental area is associated with its 5-HT(1A) receptor partial agonistic activity.
Synapse
; 65(5): 379-87, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20803620
19.
Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases.
J Med Chem
; 63(24): 15187-15217, 2020 12 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33111525
20.
Dysbindin deficiency in sandy mice causes reduction of snapin and displays behaviors related to schizophrenia.
Schizophr Res
; 106(2-3): 218-28, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18774265