1.
Nucleosides Nucleotides Nucleic Acids
; 37(2): 79-88, 2018 Feb 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29376768
RESUMO
An efficient five-step synthetic route for multigram-scale preparation of formylglycinamide ribonucleotide (FGAR) from peracetylated ß-d-ribofuranosyl azide has been developed.
Assuntos
Glicina/análogos & derivados , Ribonucleotídeos/síntese química , Azidas/química , Glicina/síntese química
2.
Carbohydr Res
; 455: 114-118, 2018 Jan 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29207316
RESUMO
An efficient method for selective anomeric deacetylation of peracetylated mono-, di-, and trisaccharides has been developed by using 2 mol% Hf(OTf)4 as catalyst in acetonitrile. Employment of ultrasonic irradiation could significantly accelerate the reaction rate. Mechanistic study confirmed the hydrolysis nature of this reaction, and NMR experimental data suggested that multiple peracetylated saccharide molecules may ligate to Hf(IV) cation primarily via the anomeric acetate to promote its specific hydrolysis.