Detalhe da pesquisa
1.
Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency.
Bioorg Med Chem Lett
; 26(24): 5926-5930, 2016 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27876318
2.
Discovery of an Atropisomeric PI3Kß Selective Inhibitor through Optimization of the Hinge Binding Motif.
ACS Med Chem Lett
; 11(6): 1236-1243, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551006
3.
Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3-Kinase (PI3K) ß Inhibitor.
J Med Chem
; 61(15): 6858-6868, 2018 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30015489