Detalhe da pesquisa
1.
Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca²âº channel blockers with analgesic activity.
Bioorg Med Chem
; 20(13): 4128-39, 2012 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22626552
2.
PARP inhibitors attenuate chemotherapy-induced painful neuropathy.
J Peripher Nerv Syst
; 17(3): 324-30, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22971094
3.
Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists.
Bioorg Med Chem Lett
; 21(5): 1338-41, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21315587
4.
Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives.
Bioorg Med Chem Lett
; 20(22): 6812-5, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20855211
5.
Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and pharmacological magnetic resonance imaging.
J Pharmacol Exp Ther
; 328(1): 141-51, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18931146
6.
Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain.
J Med Chem
; 51(3): 407-16, 2008 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-18176998
7.
Central pituitary adenylate cyclase 1 receptors modulate nociceptive behaviors in both inflammatory and neuropathic pain states.
J Pain
; 9(5): 449-56, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18337184
8.
Interleukin-1alphabeta gene-deficient mice show reduced nociceptive sensitivity in models of inflammatory and neuropathic pain but not post-operative pain.
Behav Brain Res
; 167(2): 355-64, 2006 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-16256210
9.
Attenuation of mechanical allodynia by clinically utilized drugs in a rat chemotherapy-induced neuropathic pain model.
Pain
; 110(1-2): 56-63, 2004 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15275752
10.
Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models.
J Pain
; 15(4): 387.e1-14, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24374196
11.
A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats.
Biochem Pharmacol
; 83(3): 406-18, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22153861
12.
Potentiation of analgesic efficacy but not side effects: co-administration of an α4ß2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats.
Biochem Pharmacol
; 82(8): 967-76, 2011 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21620806
13.
Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation.
Pain
; 152(5): 1165-1172, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21402443
14.
Comparison of mechanical allodynia and the affective component of inflammatory pain in rats.
Neuropharmacology
; 58(2): 537-43, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19703478
15.
The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1alphabeta knockout mice.
Behav Brain Res
; 204(1): 77-81, 2009 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19464323
16.
Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia.
Pain
; 142(1-2): 27-35, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19135797
17.
Contributions of central and peripheral TRPV1 receptors to mechanically evoked and spontaneous firing of spinal neurons in inflamed rats.
J Neurophysiol
; 100(6): 3158-66, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18829846
18.
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.
Proc Natl Acad Sci U S A
; 104(20): 8520-5, 2007 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17483457
19.
(L)-Phenylglycine, but not necessarily other alpha2delta subunit voltage-gated calcium channel ligands, attenuates neuropathic pain in rats.
Pain
; 125(1-2): 136-42, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16781071
20.
A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat.
J Pharmacol Exp Ther
; 319(3): 1376-85, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16982702