Millimeter-wave over fiber integrated sensing and communication system using self-coherent OFDM.

Orthogonal frequency-division multiplexing (OFDM) waveform is highly preferred as a dual-function candidate for integrated sensing and communication (ISAC) systems. However, the sensitivity to both carrier frequency offset (CFO) and phase noise greatly impedes its applications in millimeter-wave ISAC systems. Here, we propose and experimentally demonstrate a photonic millimeter-wave ISAC system employing the virtual-carrier-aided self-coherent OFDM technique, wherein a digitally-generated local oscillator is transmitted along with the OFDM signal. Then, a compact CFO-immune and phase noise-immune envelope detection method is implemented for down-converting millimeter-wave communication and radar echo signals. In experiments, a V-band ISAC system is successfully implemented with a simplified remote radio unit, using the remote photonic millimeter-wave heterodyning up-conversion for downlink and the envelope detection-assisted down-conversion for uplink (or radar echoes). In the converged transmission link with a 5-km fiber link and 2-m space link, the Kramers-Kronig (KK) receiver supports a communication data rate up to 16-Gbit/s by mitigating signal-signal beat interference (SSBI). More significantly, the SSBI leads to negligible effects on the sensing performance when classic matched filtering is adopted for target identification. Consequently, a 4.8-cm range resolution and a 4-mm range accuracy are obtained for the radar sensing function.

Photonic super-resolution millimeter-wave joint radar-communication system using self-coherent detection.

A millimeter-wave (MMW) joint radar-communication (JRC) system with super-resolution is proposed and experimentally demonstrated, using optical heterodyne upconversion and self-coherent detection downconversion techniques. The point lies in the designed coherent dual-band constant envelope linear frequency modulation-orthogonal frequency division multiplexing (LFM-OFDM) signal with opposite phase modulation indexes for the JRC system. Then the self-coherent detection, as a simple and low-cost means, is accordingly facilitated for both de-chirping of MMW radar and frequency downconversion reception of MMW communication, which circumvents costly high-speed mixers along with MMW local oscillators and, more significantly, achieves the real-time decomposition of radar and communication information. Furthermore, a super-resolution radar range profile is realized through the coherent fusion processing of dual-band JRC signals. In experiments, a dual-band LFM-OFDM JRC signal centered at 54 GHz and 61 GHz is generated. The two bands feature an identical instantaneous bandwidth of 2 GHz and carry an OFDM signal of 1 Gbaud, which helps to achieve a 6-Gbit/s data rate for communication and a 1.76-cm range resolution for radar.

Host PTX3 Protein and Bacterial Capsule Coordinately Regulate the Inflammatory Response during Streptococcus suis Infection.

Streptococcus suis serotype 2 (SS2) is a noteworthy zoonotic pathogen that has been responsible for large economic losses in pig production and a great threat to human health. Pentraxin 3 (PTX3) is an essential regulator of the innate immune response to bacterial pathogens; however, its role during SS2 infection is not fully understood. In this study, we found that the SS2 strain HA9801 induced a significant inflammatory response in the mouse air pouch model; this response was amplified by the treatment of exogenous PTX3 simultaneously in terms of the results of inflammatory cell recruitment and proinflammatory cytokine IL-6 production. In addition, PTX3 facilitated the phagocytosis of macrophage Ana-1 against SS2 strain HA9801. The supplementation of exogenous PTX3 significantly reduced the bacterial loads in a dose-dependent manner in lungs, livers and bloods of SS2-infected mice compared to the samples with HA9801 infection alone; this finding indicated that PTX3 may facilitate the bacterial clearance through enhancing the host inflammatory response during SS2 infection. Both PTX3 and SS2 capsular polysaccharide (CPS2) were required for the robust inflammatory response, implying that the host PTX3 protein and SS2 surface CPS2 modulate the host innate immune response in concert. All of these results suggested that PTX3 is a potential novel biological agent for the SS2 infection; however, the recommended dose of PTX3 must be evaluated strictly to avoid inducing an excessive inflammatory response that can cause serious tissue injury and animal death.