A novel immunogenomic prognostic signature in lung squamous carcinoma.

ABSTRACT: Lung squamous carcinoma (LUSC) is a common subtype of lung cancer with limited available therapy and is thus associated with poor survival. Immune infiltrating cells and immune-related genes (IRGs) play a key role in the clinical outcomes of LUSC. In the present study, we aimed to develop a potential immunogenomic prognostic signature for patients with LUSC. The transcriptional profiles of 501 LUSC samples from The Cancer Genome Atlas (TCGA) and 2498 IRGs from the ImmPort database were used to develop the signature by Cox regression analysis. Ten differentially expressed and survival-associated IRGs were used to develop the risk signature, which could serve as an independent prognostic and predictive factor for patients with LUSC. Furthermore, this risk signature correlated with overall survival and clinical features, including age, in patients with LUSC. In addition, we identified 25 transcription factors that may regulate 15 survival-associated IRGs, using a regulatory network. Collectively, this immunogenomic signature could be a robust prognostic tool for patients with LUSC and holds great promise as individualized immunotherapy for LUSC.

Investigation of the value of carotid-femoral pulse wave velocity and coronary artery lesions in prognosis of percutaneous coronary intervention patients.

OBJECTIVE: To investigate the value of carotid-femoral pulse wave velocity (CFPWV) and coronary artery lesions in assessing prognosis of percutaneous coronary intervention (PCI) patients. METHODS: A total of 300 PCI patients admitted to our hospital were selected as study subjects, and were divided into Group A (0-13 m/s, n=180) and Group B (> 13 m/s, n=120) in accordance with different carotid-femoral pulse wave velocities (CFPWVs). Coronary artery lesions, incidence rates of major adverse cardiac events (MACE) at different stages, and differences in the indexes of cardiac function were compared between the two groups. RESULTS: Compared to Group A, Group B had more severe coronary artery lesions and higher incidence rates of postoperative complications and MACE during hospital stay and 2-year follow-up (P < 0.05). At 1 month after surgery, the left ventricular stroke volume, left ventricular end-diastolic volume and left ventricular ejection fraction in Group A were higher than those of Group B. CFPWV was significantly correlated with Gensini score (GS) and incidence rate of MACE (P < 0.05), and the differences in the area under curve (AUC) of CFPWV for predicting the incidence rate of MACE were significant (P < 0.05). CONCLUSION: CFPEV, exhibits value in assessing the prognosis of PCI patients, and can effectively predict the postoperative incidence of MACE, which is conducive to the establishment of subsequent regimens. Therefore, CFPEV is worthy of clinical promotion and implementation.