Common variant (rs9939609) in the FTO gene is associated with metabolic syndrome.

Recent genome-wide association studies have showed that common variant (rs9939609) in fat mass and obesity associated (FTO) gene was significantly associated with type 2 diabetes through an effect on human body mass index/obesity. Further studies have suggested that this variant was also involved in the development of metabolic syndrome (MetS). However, the results have been inconsistent. In this study, we performed a meta-analysis to clarify the association between rs9939609 polymorphism and the risk of MetS. Published literature from PubMed, EMBASE and other databases were searched. All studies assessing the association between rs9939609 polymorphism and the risk of MetS were identified. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed-effects model. Thirteen studies (8,370 cases and 23,156 controls) using NCEP ATPIII criteria for MetS were pooled with a meta-analysis. The overall result showed that there was a statistically significant association between rs9939609 polymorphism and MetS risk (OR = 1.11, 95% CI = 1.06-1.17). Subgroup analysis based on ethnicity showed that effect size was only statistically significant in Europeans (OR = 1.11, 95% CI = 1.05-1.16). Eight studies (1,256 cases and 2,551 controls) using IDF criteria for MetS were pooled with a meta-analysis. The overall analysis suggested that rs9939609 polymorphism was significantly associated with MetS risk (OR = 1.32, 95% CI = 1.13-1.54). Subgroup analysis stratified by ethnicity suggested that effect size was only statistically significant in Asians (OR = 1.33, 95% CI = 1.10-1.61). Our results suggested that FTO rs9939609 polymorphism was significantly associated with the increased risk of MetS in European and Asian populations. Mechanistic investigation is also needed to clarify the effect of FTO gene in the predisposition to MetS.

Gender differences in the prevalence of diabetes mellitus in chronic hospitalized patients with schizophrenia on long-term antipsychotics.

Gender-specific relationships between diabetes mellitus (DM) and schizophrenia have previously received little systematic study. The results showed that the overall DM prevalence was 20% with rates of 17% (58/343) in males and 27% (46/172) in females (p<0.01). Furthermore, increased body mass index (BMI), abdominal obesity and antipsychotic types were predictors of diabetes in these chronic schizophrenic patients.

Angiotensin-converting enzyme I/D polymorphism is not associated with type 2 diabetes in a Chinese population.

OBJECTIVE: A role for the angiotensin-converting enzyme (ACE) gene has been suggested in the aetiology of type 2 diabetes (T2DM). However, results have been inconsistent. In this study, we performed a meta-analysis to further clarify the association between ACE I/D polymorphism and T2DM risk in a Chinese population. METHODS: PubMed, EMBASE, CNKI and Wan Fang Data were searched for eligible studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a fixed-effects model or random-effects model. RESULTS: : A total of 41 studies (4708 cases and 5368 controls) for the association between ACE I/D polymorphism and T2DM in a Chinese population were identified. The pooled ORs for the association between ACE I/D polymorphism and T2DM risk were not statistically significant under all genetic models (co-dominant model: DD vs. II: OR = 1.17, 95% CI 0.97-1.42 and ID vs. II: OR = 1.01, 95% CI 0.93-1.10; dominant model: OR = 1.06, 95% CI 0.94-1.19; multiplicative model: OR = 1.08, 95% CI 0.98-1.18). Although a marginally significant association was observed under a recessive model (OR = 1.17, 95% CI 1.00-1.36), robustness of this estimate could not be established under additional sensitivity analyses. CONCLUSIONS: : The meta-analysis presented in this study indicated that ACE I/D polymorphism may not be associated with the risk of T2DM in the Chinese population.