Detalhe da pesquisa
1.
Design, synthesis, and biological evaluation of novel dual FFA1 and PPARδ agonists possessing phenoxyacetic acid scaffold.
Bioorg Med Chem
; 56: 116615, 2022 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35051813
2.
ZLY032, the first-in-class dual FFA1/PPARδ agonist, improves glucolipid metabolism and alleviates hepatic fibrosis.
Pharmacol Res
; 159: 105035, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32562818
3.
A novel FFA1 agonist, CPU025, improves glucose-lipid metabolism and alleviates fatty liver in obese-diabetic (ob/ob) mice.
Pharmacol Res
; 153: 104679, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32014571
4.
Design, synthesis, and biological evaluation of novel dual PPARα/δ agonists for the treatment of T2DM.
Bioorg Chem
; 101: 103963, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32480174
5.
Discovery of novel dual PPARα/δ agonists based on benzimidazole scaffold for the treatment of non-alcoholic fatty liver disease.
Bioorg Chem
; 99: 103803, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32251945
6.
Design, synthesis, and biological evaluation of novel dual FFA1 (GPR40)/PPARδ agonists as potential anti-diabetic agents.
Bioorg Chem
; 92: 103254, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31518760
7.
Discovery of HWL-088: A highly potent FFA1/GPR40 agonist bearing a phenoxyacetic acid scaffold.
Bioorg Chem
; 92: 103209, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31487621
8.
A Clinically Translatable Ternary Platinum(IV) Prodrug for Synergistically Reversing Drug Resistance â¯.
J Med Chem
; 66(6): 4045-4058, 2023 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36897884
9.
Discovery of the First-in-Class Intestinal Restricted FXR and FABP1 Dual Modulator ZLY28 for the Treatment of Nonalcoholic Fatty Liver Disease.
J Med Chem
; 66(9): 6082-6104, 2023 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37079895
10.
A ROS-Responsive Liposomal Composite Hydrogel Integrating Improved Mitochondrial Function and Pro-Angiogenesis for Efficient Treatment of Myocardial Infarction.
Adv Healthc Mater
; 11(19): e2200990, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35848825
11.
Discovery of a novel and orally active Farnesoid X receptor agonist for the protection of acetaminophen-induced hepatotoxicity.
Chem Biol Drug Des
; 99(3): 483-495, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34936214
12.
Discovery of new and highly effective quadruple FFA1 and PPARα/γ/δ agonists as potential anti-fatty liver agents.
Eur J Med Chem
; 229: 114061, 2022 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34954593
13.
Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfß1/Smad pathway in mice.
Biochim Biophys Acta Mol Basis Dis
; 1868(12): 166556, 2022 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36154893
14.
Design, synthesis, and biological studies of novel 3-benzamidobenzoic acid derivatives as farnesoid X receptor partial agonist.
Eur J Med Chem
; 211: 113106, 2021 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33360559
15.
Discovery of the first-in-class dual PPARδ/γ partial agonist for the treatment of metabolic syndrome.
Eur J Med Chem
; 225: 113807, 2021 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34455359
16.
Current status of GPR40/FFAR1 modulators in medicinal chemistry (2016-2019): a patent review.
Expert Opin Ther Pat
; 30(1): 27-38, 2020 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-31771391
17.
HWL-088, a new potent free fatty acid receptor 1 (FFAR1) agonist, improves glucolipid metabolism and acts additively with metformin in ob/ob diabetic mice.
Br J Pharmacol
; 177(10): 2286-2302, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31971610
18.
HWL-088, a new and highly effective FFA1/PPARδ dual agonist, attenuates nonalcoholic steatohepatitis by regulating lipid metabolism, inflammation and fibrosis.
J Pharm Pharmacol
; 72(11): 1564-1573, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-32734608
19.
Hepatoprotective effects of ZLY16, a dual peroxisome proliferator-activated receptor α/δ agonist, in rodent model of nonalcoholic steatohepatitis.
Eur J Pharmacol
; 882: 173300, 2020 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32592770
20.
Discovery of first-in-class thiazole-based dual FFA1/PPARδ agonists as potential anti-diabetic agents.
Eur J Med Chem
; 164: 352-365, 2019 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30605833