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BACKGROUND: Patients with schizophrenia (SCZ) exhibit difficulties deficits in recognizing facial expressions with unambiguous valence. However, only a limited number of studies have examined how these patients fare in interpreting facial expressions with ambiguous valence (for example, surprise). Thus, we aimed to explore the influence of emotional background information on the recognition of ambiguous facial expressions in SCZ. METHODS: A 3 (emotion: negative, neutral, and positive) × 2 (group: healthy controls and SCZ) experimental design was adopted in the present study. The experimental materials consisted of 36 images of negative emotions, 36 images of neutral emotions, 36 images of positive emotions, and 36 images of surprised facial expressions. In each trial, a briefly presented surprised face was preceded by an affective image. Participants (36 SCZ and 36 healthy controls (HC)) were required to rate their emotional experience induced by the surprised facial expressions. Participants' emotional experience was measured using the 9-point rating scale. The experimental data have been analyzed by conducting analyses of variances (ANOVAs) and correlation analysis. RESULTS: First, the SCZ group reported a more positive emotional experience under the positive cued condition compared to the negative cued condition. Meanwhile, the HC group reported the strongest positive emotional experience in the positive cued condition, a moderate experience in the neutral cued condition, and the weakest in the negative cue condition. Second, the SCZ (vs. HC) group showed longer reaction times (RTs) for recognizing surprised facial expressions. The severity of schizophrenia symptoms in the SCZ group was negatively correlated with their rating scores for emotional experience under neutral and positive cued condition. CONCLUSIONS: Recognition of surprised facial expressions was influenced by background information in both SCZ and HC, and the negative symptoms in SCZ. The present study indicates that the role of background information should be fully considered when examining the ability of SCZ to recognize ambiguous facial expressions.
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Reconhecimento Facial , Esquizofrenia , Humanos , Emoções , Reconhecimento Psicológico , Expressão Facial , ChinaRESUMO
Available evidence suggests that emotions influence arithmetic, and explicit emotion regulation modulates the effect of anxiety on arithmetic performance. However, neural mechanisms by which implicit emotion regulation affects these phenomena remain unclear, particularly under distinct affective priming contexts. Twenty-two college students were required to perform multiple tasks in sequence, including an idioms matching task, a multiplication computational estimation task (MCE task), an emotion judgement task (EJ task), and an emotion assessment task (EA task). Behavioral performance was measured via accuracy and response time during the MCE task, and ratings of the EA task, while eletrophysiological response was measured via the contingent negative variation (CNV) elicited by completing the MCE task. Decreased response time and emotional intensity ratings were observed for priming emotion regulation idioms compared to priming neutral idioms. Priming emotion regulation idioms attenuated early CNV amplitudes under happiness priming, and attenuated both early and late CNV amplitudes under fear priming. These results suggested that implicit reappraisal and suppression are promising strategies to enhance arithmetic performance and alleviate the adverse effects of affective priming, especially under fear priming.
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Regulação Emocional , Emoções/fisiologia , Medo , Felicidade , Humanos , MatemáticaRESUMO
Existing methods for measuring implicit sequence-learning consciousness are conducted offline. Based on the traditional measurement of cued-generation task, this study implemented an online measurement method by converting a generation task into a forced-choice task to observe the dynamic changes of consciousness in the implicit sequence-learning process. In this study, we compared the performance of online measurement task and traditional sequence-learning tasks in 31 university students. The results revealed that the online indicators were significantly correlated with classic consciousness indicators and typical ERP components of consciousness. Without affecting the development of consciousness, the online measurement indicators were found to promptly and effectively reflect the gradually changing progression of consciousness in implicit sequence learning.
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Estado de Consciência , Aprendizagem Seriada , Análise e Desempenho de Tarefas , Humanos , Estado de Consciência/fisiologia , Sinais (Psicologia) , Internet , Aprendizagem/fisiologia , Tempo de Reação/fisiologia , Aprendizagem Seriada/fisiologia , Estudantes , Desempenho Psicomotor/fisiologiaRESUMO
Combined with the prime paradigm, the present study aimed to explore the influence of emotion (anger, fear, happiness, and neutral) on performing multiplication estimation. Participants were asked to complete a two-digit multiplication estimation task using the down-up strategy (e.g., doing 20 × 80 = 1600 for 24 × 79). Behavioral results showed that the reaction time for completing multiplication estimation tasks under happy conditions was shorter than for those under anger and fear, and it was shorter under neutral than under fearful conditions. The ERP results showed that about 100 ms after multiplication estimation task onset, multiplication estimation execution in the context of happiness (vs. neutral) elicited smaller P1 amplitudes; about 170 ms after multiplication estimation task onset, the N170 amplitudes elicited by multiplication estimation strategy execution under different emotional priming conditions showed no significant differences. The above results showed that the impact of emotion priming demonstrates the occurrence of a dynamic process when participants use a specified strategy to complete the multiplication estimation task. The present study revealed that emotional valence modulated arithmetic strategy execution, suggesting the role of different emotions should be fully considered in similar study.
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Emoções , Expressão Facial , Eletroencefalografia , Potenciais Evocados , Medo , Felicidade , HumanosRESUMO
Discovery of epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs) are two milestones in people exploring the nature of malignant tumor in recent decades. Although some studies have presented the potential connections between them, the link details, underneath their superficial correlation, are largely unknown. In this study, we identified a small subpopulation of NANOG-positive colorectal cancer (CRC) cells, and demonstrated that they exhibited characteristics of CSCs and EMT traits simultaneously. Furthermore, we found that NANOG was a core factor in regulating both of EMT and stemness in CRC cells, NANOG modulate EMT and metastasis by binding to Slug promoter and transcriptionally regulate Slug expression. For the first time, we demonstrated that NANOG was regulated by extracellular IGF signaling pathway via STAT3 phosphorylation in CRC. This coincides with that IGF receptor IGF-1R is often increasing expressed in malignant metastasis colon cancer. Taken together, our data define the crucial functions of IGF/STAT3/NANOG/Slug signaling axis in the progression of CRC by operating EMT and CSCs properties, which make them served as potential therapeutic targets for treatment of CRC.
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Neoplasias Colorretais/genética , Fator de Crescimento Insulin-Like I/biossíntese , Proteína Homeobox Nanog/biossíntese , Receptores de Somatomedina/biossíntese , Fator de Transcrição STAT3/biossíntese , Fatores de Transcrição da Família Snail/biossíntese , Linhagem Celular Tumoral , Neoplasias Colorretais/metabolismo , Neoplasias Colorretais/patologia , Transição Epitelial-Mesenquimal/genética , Regulação Neoplásica da Expressão Gênica , Humanos , Fator de Crescimento Insulin-Like I/genética , Proteína Homeobox Nanog/genética , Metástase Neoplásica , Células-Tronco Neoplásicas/metabolismo , Células-Tronco Neoplásicas/patologia , Receptor IGF Tipo 1 , Receptores de Somatomedina/genética , Fator de Transcrição STAT3/genética , Fatores de Transcrição da Família Snail/genéticaRESUMO
[This corrects the article DOI: 10.1371/journal.pone.0252671.].
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This study aimed to explore the influence of word priming on mathematical problem solving. In two experiments, participants were required to finish multiplication estimation tasks with a specified estimation strategy under different word priming conditions (Experiment 1: concrete words vs. Experiment 2: abstract words). The results showed that: (1) under the concrete word priming condition, in comparison to neutral, positive word priming improved accuracies (ACCs) when using a down-up strategy (e.g., doing 40 × 80 = 3200 for 43 × 78), while both positive and negative word priming reduced reaction time (RT); (2) under the abstract word priming condition, both positive and negative (vs. neutral) abstract word priming reduced RTs, while individuals' ACCs of completing the estimation task were not influenced by valence. The present study showed that whether concrete words or abstract words were adopted as experimental stimuli, participants' performance of completing mathematical problems was modulated by the valence of the priming word, which led us to develop a better understanding of how arithmetic performance is influenced by word processing.
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Resolução de Problemas , Tempo de Reação , Humanos , Masculino , Feminino , Adulto , Adulto Jovem , MatemáticaRESUMO
Implicit emotion regulation provides an effective means of controlling emotions triggered by a single face without conscious awareness and effort. Crowd emotion has been proposed to be perceived as more intense than it actually is, but it is still unclear how to regulate it implicitly. In this study, participants viewed sets of faces of varying emotionality (e.g. happy to angry) and estimated the mean emotion of each set after being primed with an expressive suppression goal, a cognitive reappraisal goal, or a neutral goal. Faster discrimination for happy than angry crowds was observed. After induction of the expressive suppression goal instead of the cognitive reappraisal goal, augmented N170 and early posterior negativity (EPN) amplitudes, as well as attenuated late positive potential (LPP) amplitudes, were observed in response to happy crowds compared to the neutral goal. Differential processing of angry crowds was not observed after the induction of both regulatory goals compared to the neutral goal. Our findings thus reveal the happy-superiority effect and that implicit induction of expressive suppression improves happy crowd emotion recognition, promotes selective coding, and successfully downregulates the neural response to happy crowds.
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Expressão Facial , Humanos , Feminino , Masculino , Adulto Jovem , Adulto , Felicidade , Eletroencefalografia , Potenciais Evocados/fisiologia , Emoções/fisiologia , Regulação Emocional/fisiologia , Encéfalo/fisiologia , Reconhecimento Facial/fisiologiaRESUMO
Emotion recognition will be challenged for individuals when visual signals are degraded in real-life scenarios. Recently, researchers have conducted many studies on the distinct neural activity between clear and degraded audiovisual stimuli. These findings addressed the "how" question, but the precise stage of the distinct activity that occurred remains unknown. Therefore, it is crucial to use event-related potential (ERP) to explore the "when" question, just the time course of the neural activity of degraded audiovisual stimuli. In the present research, we established two conditions: clear auditory + degraded visual (AcVd) and clear auditory + clear visual (AcVc) multisensory conditions. We enlisted 31 participants to evaluate the emotional valence of audiovisual stimuli. The resulting data were analyzed using ERP in time domains and Microstate analysis. Current results suggest that degraded vision impairs the early-stage processing of audiovisual stimuli, with the superior parietal lobule (SPL) regulating audiovisual processing in a top-down fashion. Additionally, our findings indicate that negative and positive stimuli elicit greater EPN compared to neutral stimuli, pointing towards a subjective motivation-related attentional regulation. To sum up, in the early stage of emotional audiovisual processing, the degraded visual signal affected the perception of the physical attributes of audiovisual stimuli and had a further influence on emotion extraction processing, leading to the different regulation of top-down attention resources in the later stage.
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Potenciais Evocados , Percepção Visual , Humanos , Percepção Visual/fisiologia , Estimulação Acústica , Potenciais Evocados/fisiologia , Emoções/fisiologia , Percepção Auditiva/fisiologia , Estimulação LuminosaRESUMO
Introduction: Research has demonstrated that cognitive flexibility is associated with academic achievement, with poorer cognitive flexibility being linked to poorer academic performance. Strategy conversion is an example of cognitive flexibility, which requires individuals to quickly and flexibly switch between strategies depending on the task at hand. Studies have investigated the impact of emotional motivation on cognitive flexibility, with varying results. Furthermore, research has indicated that a high task load increases psychological burden and reduces cognitive flexibility, but few studies have analyzed the impact of task load on the relationship between emotional motivation and cognitive flexibility. This study sought to investigate the effect of emotional motivation on cognitive flexibility based on strategy switching, and the moderating effect of task load. Methods: Three experiments were conducted. Experiment 1 used forced conversion paradigm with a moderate task load that required participants to estimate tasks using a given strategy. Experiment 2 employed matched conversion paradigm with a high task load, informing participants of the strategies to be used but without any clues, necessitating the selection and execution of appropriate strategies based on the question features. Experiment 3 adopted free conversion paradigm with a relatively low task load, allowing participants to freely choose and execute strategies without any correctness or error criteria. Results: The intensity and direction of emotional motivation have a complicated and fluctuating impact on the flexibility to utilize strategies. When the task workload is high, the intensity of emotional motivation has a significant impact on strategy utilization flexibility, with low approach motivation being more conducive to flexibility. Conversely, when the task workload is low, the direction of emotional motivation has a greater effect, with high avoidance motivation being more advantageous. Discussion: This study demonstrated that high workload could bring about a low intensity advantage, while low workload could induce an avoidance direction advantage, suggesting that task load could moderate the impact of emotional motivation on arithmetic strategy utilization flexibility, and avoidance motivation is not always detrimental to cognitive flexibility.
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Previous studies have shown that some negative emotions hinder estimation strategy execution. However, these studies rarely investigate the influence of negative emotions on the estimation strategy execution in individuals with trait anxiety. The present study examines the relationship between negative emotions and trait anxiety in individuals' estimation strategy execution. Moreover, it looks into the influence of different emotion regulation strategies on their estimation strategy execution. In October 2010, 803 college students were evaluated using the Trait Anxiety Scale. From these participants, individuals with high and low trait anxiety were selected to complete the double-digit multiplication estimation task. The results showed that the estimation strategy's execution speed in individuals with high trait anxiety was slower than those with low trait anxiety under negative emotions (t (113) = −2.269, p = 0.025, d = 0.427). Both expression inhibition and cognitive reappraisal could significantly improve the execution speed of the estimation strategy in low trait anxiety (p < 0.001). For individuals with high trait anxiety, cognitive reappraisal regulating negative emotions can promote the estimation strategy's execution speed (p = 0.031). However, the use of expression inhibition has no significant effect on estimation strategy execution (p = 0.101). In summary, the present study revealed that different emotion regulation strategies moderated the arithmetic strategy execution of individuals with trait anxiety, and cognitive reappraisal had a better effect in individuals with high trait anxiety.
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A large number of studies have studied the influence of emotional experience on an individual's estimation performance, but the influence of implicit emotion regulation is still unknown. Participants were asked to complete the following tasks in order: idiom matching task, multiplication computational estimation task (MCE task), gender judgment task (GJ task), and emotional experience intensity assessment task. The words matching task was adopted to achieve the purpose of implicit emotion regulation (implicit reappraisal and implicit suppression). Behavioral results showed that implicit reappraisal and implicit suppression equally contributed to improving an individual's estimation speed (but not ACC (accuracy)). The MCE task related ERP (event-related potential) results showed that the influence of implicit emotion regulation on estimation consisted of two phases. In the first phase (encoding phase), implicit reappraisal both enhanced (larger P1 amplitudes) and weakened (smaller N170 amplitudes) an individual's encoding sensitivity, while implicit suppression enhanced an individual's encoding sensitivity (larger P1 amplitudes). In the second phase (estimation strategies retrieval phase), implicit reappraisal (but not implicit suppression) cost more attention resources (larger LPC2 and LPC3 amplitudes). The present study suggested that both implicit reappraisal and implicit suppression contributed to improving an individual's estimation performance, and the regulation effect of implicit suppression (vs. implicit reappraisal) was better.
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The present study explored the role of snapshot emotional priming and math anxiety in estimation strategy selection. Participants were asked to complete a two-digit multiplication estimation task (e.g., 34 × 67) under explicit (Experiment 1) and implicit (Experiment 2) snapshot emotional priming conditions by freely choosing to use DU (down-up, e.g., doing 30 × 70 = 2100 for 34 × 67) or UD (up-down, e.g., doing 40 × 60 = 2400 for 34 × 67) strategies to arrive as close as possible to the correct answer. In Experiment 1, individuals' estimation performance was positively influenced by explicit happy priming (shorter RT (reaction time)), while not affected by explicit fear priming. In Experiment 2, individuals' estimation ACC (accuracy) when using the UD strategy was negatively affected by both implicit happy and fear priming, but their RT when using DU and UD strategies was positively impacted by implicit happy priming. In both experiments, the correlations between math anxiety and estimation performance (ACC, RT, and strategy selection adaptivity) was not significant. The present study suggests that fear priming was not always detrimental to individuals' estimation performance, and happy priming did not always universally improve individuals' estimation performance. Additionally, estimation strategy selection was not influenced by math anxiety.
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Ansiedade , Emoções , Ansiedade/psicologia , Transtornos de Ansiedade , Medo , Humanos , MatemáticaRESUMO
Previous studies have shown that negative emotional experiences are detrimental to individual's arithmetic performance, and no study has investigated whether such negative influence can be improved through emotional regulation. This study aimed to explore the relationship between emotion regulation and individual's performance in completing arithmetic problem verification task. Participants were asked to complete arithmetic problem verification task using the down-up strategy (e.g., doing 30 × 70 = 2100 for 34 × 67), under neutral, happy, and fear priming conditions, during which they were asked to regulate their emotional experience by using cognitive reappraisal or expressive suppression. Behavioral results showed that, under happy priming condition, cognitive reappraisal (but not expression suppression) contributed to improving individual's estimation speed. Additionally, under happy and fear priming conditions, cognitive reappraisal (vs. expression suppression) reduced individuals' emotional experience intensity. The arithmetic problem verification task-related ERP results showed that the P1 amplitudes elicited by using cognitive reappraisal (vs. freely view) were larger under happy and fear priming conditions, but the P1 amplitudes elicited by using expression suppression were larger only under happy condition. Meanwhile, the corresponding N170 amplitudes were smaller when using cognitive reappraisal and expression suppression (vs. freely view). Additionally, using cognitive reappraisal (vs. expression suppression) cost less cognitive resource (smaller LPC amplitudes). The present study indicated that both cognitive reappraisal and expression suppression contributed to improving individual's arithmetic performance, and the regulation effect of cognitive reappraisal was better than that of expression suppression.
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Cognição , Emoções , Medo , Felicidade , Humanos , MatemáticaRESUMO
We aimed to establish and evaluate a standardized emotional situation sentence system (ESSS) relevant to the lives of college students to supplement prior literature and adapt to the needs of emotional research. Two studies were designed for this research; study 1 examined the effect of words in the ESSS and study 2 involved the use of pictures. For Study 1, 778 items were selected by 607 college students and 15 experts. We then tested the scale with 80 undergraduate participants. The ESSS sentences were rated on their degree of valence, arousal, and dominance using a 9-point scale. Cronbach's α (greater than 0.986) of the overall score as well as each sub-score in the three components confirmed the scale's reliability. As seen on a scatter plot, the results suggest that negative emotions (fear, disgust, anger, sadness, anxiety) are convergent and different from the distribution of positive (happiness) and neutral emotions. Study 2 included 30 participants to compare the difference in valence and arousal between the ESSS and emotional pictures. The results indicate that the ESSS is a standardized, situational, and ecological emotional contextual text system, well-suited to invoke emotion in college students. The ESSS has significantly better arousal and potency than pictures; moreover, it can be applied to experimental studies of anxiety-related emotions. However, emotion pictures have shorter response times, and wider application ranges, and they can include more cross-cultural characteristics compared to words.
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Emoções , Adolescente , Adulto , Nível de Alerta/fisiologia , Humanos , Masculino , Tempo de Reação , Reprodutibilidade dos Testes , Adulto JovemRESUMO
Previous study have explored the influence of explicit emotion priming on computational estimation strategy execution, but the corresponding influence of implicit emotion priming still remains unknown. The present study aimed to solve this problem. Participants were asked to complete two-digit multiplication computational estimation task, under different implicit emotion priming conditions (gender judgment task). In the two-digit multiplication computational estimation task, the computational estimation question was presented in the middle of the screen, meanwhile, two alternative answers were presented side by side at the bottom of the screen, participants were required to select which answer is correct, by using the down-up strategy (e.g., doing 30 × 50 = 1500 for 34 × 46). Behavioral results showed that the response speed under implicit happy and fear (vs. neutral and angry) priming conditions was quicker, and the accuracy under different priming conditions showed no significant difference. The ERP results showed that the influence of implicit emotion priming on computational estimation strategy execution consisted of two phases: in the first phase, the N1 amplitudes elicited by completing the multiplication computational estimation task were smaller under implicit fear (vs. angry) priming condition; in the second phase, the corresponding P2 amplitudes under implicit happy (vs. fear) priming condition were smaller. The present study indicated that implicit happy and fear experience contributed to complete computational estimation tasks, suggesting that implicit negative emotional (e.g., fear) experience was not always detrimental to computational estimation strategy execution.
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Medo , Felicidade , Ira , Emoções , Expressão Facial , HumanosRESUMO
Emotion intensity is important for emotional regulation process. The studies in this literature, however, have generally focused on the down-regulation of negative emotions. Few studies have examined the down-regulation of positive emotions. Distraction and expressive suppression belong to disengagement strategies, which direct coping efforts away from emotions. Participants are more likely to select distraction and expressive suppression when motivated to down-regulate their emotions. Therefore, this study aimed to assess the impact of emotional intensity on down-regulating positive emotions via distraction and expressive suppression. The event-related potentials (ERPs) of college students were recorded while they were instructed to down-regulate positive emotions using expressive suppression or distraction versus free viewing when exposed to high- and low-intensity pleasant stimuli. Subsequently, participants were instructed to rate their positive experience using a 9-point scale. Supporting our predictions, behavioral results showed that both strategies could dramatically reduce high-intensity positive experience relative to viewing, and distraction led to a larger reduction of high-intensity positive experience than expressive suppression. Both strategies could not decrease low-intensity positive experience relative to viewing. ERP results showed that distraction successfully attenuated the early (500-700 ms) and late (700-1500 ms) stage of late positive potential (LPP) in high-intensity, and in low-intensity it modulated the early (but not late) LPP relative to viewing. Unexpectedly, expressive suppression effectively attenuated the early and late LPP in high- and low-intensity relative to viewing. The findings suggest that expressive suppression and distraction can effectively down-regulate positive emotions; however, distraction is more susceptible to emotional intensity and time.
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Regulação Emocional , Emoções , Adaptação Psicológica , Regulação para Baixo , Potenciais Evocados , HumanosRESUMO
Diabetes mellitus (DM) is a major world health problem and one of the most studied diseases, which are highly prevalent in the whole world, it is frequently associated with severe clinical complications, such as diabetic cardiomyopathy, nephropathy, retinopathy, neuropathy etc. Scientific research is continuously casting about for new monomer molecules from Chinese herbal medicine that could be invoked as candidate drugs for fighting against diabetes and its complications. Resveratrol (RES), a polyphenol phytoalexin, possesses diverse biochemical and physiological actions, including antiplatelet, estrogenic, and anti-inflammatory properties. It is recently gaining scientific interest for RES in controlling blood sugar and fighting against diabetes and its complications properties in various types of diabetic models. These beneficial effects seem to be due to the multiple actions of RES on cellular functions, which make RES become a promising molecule for the treatment of diabetes and diabetic complications. Here, we review the mechanism of action and potential therapeutic use of RES in prevention and mitigation of these diseases in recent ten years to provide a reference for further research and development of RES.
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Complicações do Diabetes/tratamento farmacológico , Complicações do Diabetes/prevenção & controle , Diabetes Mellitus/tratamento farmacológico , Diabetes Mellitus/prevenção & controle , Resveratrol/farmacologia , Animais , Glicemia/efeitos dos fármacos , Ensaios Clínicos como Assunto , Glucose/metabolismo , Humanos , Estresse Oxidativo/efeitos dos fármacos , Resveratrol/químicaRESUMO
Convergent creativity is a form of creative thinking that uses existing knowledge or traditional methods to analyze available information and generate an appropriate solution. The differences in the performance of participants in convergent creativity caused by bilingual learning is a popular research area in creativity. A final sample of 68 participants was asked to complete the remote associates test (RAT). The results indicate that a moderate positive correlation exists between bilingual learning and convergent creativity. Students who want to study abroad perform better on the RAT than those who do not, and this effect is mediated by second language proficiency. These findings suggest that improving students' English proficiency and increasing their opportunities to study abroad may be effective ways to promoting convergent creativity.