[Periodic dynamic observation and analysis of cellular and humoral immunity indexes of adults infected with Omicron BA.1].

Objective: To analyze the immunological characteristics and antibody changes of patients infected with the Omicron BA.1 and evaluate the possibility of secondary infection. Methods: A total of 104 patients infected with Omicron BA.1 in the Jinnan District of Tianjin from January 8 to February 2, 2022, were included in the study. The control group and case group were matched 1∶1 based on age, sex and vaccination status. Serum was collected from the case group and control group at 3, 6 and 9 months after infection. The serum levels of interleukin4 (IL-4), IL-5 and interferon-gamma (IFN-γ), as well as the positive rates of IgG, IgG1 and IgG2, were detected by ELISA. Results: The highest concentration of IFN-γ in the case group at 6 months after infection was 145.4 pg/ml, followed by a decrease in concentration. The concentrations of IL-4 and IL-5 began to decrease at 6 months after infection (all P<0.001). There was no significant difference in the IgG2 positive rate between the case group and the control group at 6 months after BA.1 infection. However, at 9 months, there was a significant decrease compared to the control group (P=0.003). The ratio of IFN-γ/IL4 at 3 months after infection in the case group was lower than that in the control group (P<0.001). There was no significant difference in the ratio between the case group and the control group at 9 months after infection. Conclusion: The cellular immune function has been impaired at 3 months after infection with BA.1, and the specific cellular immune and humoral immune functions decrease significantly after 6 months, and the risk of secondary infection increases.

[Relation among syndrome of spleen deficiency and stagnation of liver-qi and electrogastrogram, gastric mucosal pathology and pulse-cardiovascular function in chronic gastric diseases].

In this research, Syndrome of Deficiency of Spleen (DS) and Stagnation of Liver-Qi (SLQ) as well as observations of electrogastrogram (EGG), gastric mucosal pathology and pulse cardiovascular examination were investigated in 56 cases of chronic gastric diseases (CGD). The results showed: (1) In SLQ with DS the amplitude of EGG was significantly higher than that of the control group (P < 0.01), it often indicated the active period of pathologic change, but in DS with SLQ, the amplitude of EGG was significantly lower than that of the control group (P < 0.01), it frequently denoted the static period. In case that DS equalled to SLQ, the amplitude of EGG was significantly higher than that of the control group (P < 0.01). It revealed that there were no significant difference between the patient's number of static and active periods (P > 0.05). It is valuable in Syndrome Differentiation of Deficiency and Excess and analysis of Superficiality and Origin in CGD. (2) Cardiovascular function was also affected in Syndrome differentiation of DS and SLQ. DS with SLQ manifested itself as reduction of left ventricle pump and declination for metabolism of microcirculation, they had significant difference as compared with the control group (P < 0.05), while SLQ with DS or equality between DS and SLQ had the normal function of left ventricle pump and metabolism of microcirculation, even though cardiac output were higher than that of control group (P < 0.05). It showed that the traditional Chinese medicine theory of interrelation among Heart and Spleen, Liver had their own hemodynamic bases.