Detalhe da pesquisa
1.
Discovery of CYR715: A novel carboxylic acid-containing soluble guanylate cyclase stimulator.
Bioorg Med Chem Lett
; 40: 127886, 2021 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33662540
2.
Soluble Guanylate Cyclase Stimulators and Activators.
Handb Exp Pharmacol
; 264: 355-394, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-30689085
3.
An exploratory, randomised, placebo-controlled, 14 day trial of the soluble guanylate cyclase stimulator praliciguat in participants with type 2 diabetes and hypertension.
Diabetologia
; 63(4): 733-743, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31858186
4.
Praliciguat inhibits progression of diabetic nephropathy in ZSF1 rats and suppresses inflammation and apoptosis in human renal proximal tubular cells.
Am J Physiol Renal Physiol
; 319(4): F697-F711, 2020 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32865013
5.
Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease.
J Pharmacol Exp Ther
; 365(3): 664-675, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29643251
6.
Correction to: Soluble Guanylate Cyclase Stimulators and Activators.
Handb Exp Pharmacol
; 264: 425, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-31273468
7.
An impaired natriuretic peptide hormone system may play a role in COVID-19 severity in vulnerable populations.
FASEB Bioadv
; 2(10): 596-599, 2020 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-32838215
8.
Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical-stage soluble guanylate cyclase stimulator in rats.
Pharmacol Res Perspect
; 8(2): e00579, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32314550
9.
Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease.
Front Pharmacol
; 11: 419, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32322204
10.
Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains.
Nat Biotechnol
; 21(2): 150-6, 2003 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12536215
11.
Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans.
ACS Med Chem Lett
; 7(5): 465-9, 2016 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27190594
12.
Genome image programs: visualization and interpretation of Escherichia coli microarray experiments.
Genetics
; 167(4): 2111-9, 2004 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15342544
13.
Escherichia coli spotted double-strand DNA microarrays: RNA extraction, labeling, hybridization, quality control, and data management.
Methods Mol Biol
; 224: 61-78, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12710666
14.
The natriuretic peptide uroguanylin elicits physiologic actions through 2 distinct topoisomers.
Hypertension
; 53(5): 867-76, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19289652
15.
Structural origins of adenine-tract bending.
Proc Natl Acad Sci U S A
; 100(5): 2369-73, 2003 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-12586860