Detalhe da pesquisa
1.
Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities.
Bioorg Med Chem
; 85: 117273, 2023 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37030194
2.
Transporter Activity Changes in Nonalcoholic Steatohepatitis: Assessment with Plasma Coproporphyrin I and III.
J Pharmacol Exp Ther
; 376(1): 29-39, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33127749
3.
MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity.
Cell Metab
; 34(11): 1732-1748.e5, 2022 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36323235
4.
Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases.
J Med Chem
; 64(21): 15549-15581, 2021 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34709814
5.
Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway.
J Pharmacol Exp Ther
; 324(2): 507-16, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18025247
6.
Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists.
J Med Chem
; 61(3): 681-694, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29316397
7.
Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode.
J Med Chem
; 60(4): 1417-1431, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28112924
8.
Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors.
J Med Chem
; 49(13): 3770-3, 2006 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-16789734
9.
Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
J Med Chem
; 49(22): 6439-42, 2006 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-17064063
10.
Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors.
J Med Chem
; 49(12): 3520-35, 2006 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16759095
11.
Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes.
J Med Chem
; 49(21): 6416-20, 2006 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-17034148
12.
Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo.
Mol Cancer Ther
; 4(6): 977-86, 2005 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15956255
13.
Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice.
Diabetes
; 52(1): 21-8, 2003 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-12502489
14.
Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis.
Diabetes
; 51(8): 2405-11, 2002 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12145151
15.
Endothelin antagonism improves hepatic insulin sensitivity associated with insulin signaling in Zucker fatty rats.
Metabolism
; 54(11): 1515-23, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16253642
16.
Metabolic responses with endothelin antagonism in a model of insulin resistance.
Metabolism
; 54(6): 735-40, 2005 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15931607
17.
Antisense protein tyrosine phosphatase 1B reverses activation of p38 mitogen-activated protein kinase in liver of ob/ob mice.
Mol Endocrinol
; 17(6): 1131-43, 2003 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12649327
18.
Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B.
J Med Chem
; 46(11): 2093-103, 2003 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-12747781
19.
PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat.
Mol Cell Endocrinol
; 203(1-2): 155-68, 2003 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-12782412
20.
Metabolic responses in a model of insulin resistance: comparison between oral glucose and meal tolerance tests.
Metabolism
; 51(5): 595-8, 2002 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-11979391