Detalhe da pesquisa
1.
Effects of Sirolimus treatment on patients with ß-Thalassemia: Lymphocyte immunophenotype and biological activity of memory CD4+ and CD8+ T cells.
J Cell Mol Med
; 27(3): 353-364, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36625233
2.
The rs368698783 (G>A) Polymorphism Affecting LYAR Binding to the Aγ-Globin Gene Is Associated with High Fetal Hemoglobin (HbF) in ß-Thalassemia Erythroid Precursor Cells Treated with HbF Inducers
Int J Mol Sci
; 24(1)2023 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36614221
3.
Decrease in α-Globin and Increase in the Autophagy-Activating Kinase ULK1 mRNA in Erythroid Precursors from ß-Thalassemia Patients Treated with Sirolimus.
Int J Mol Sci
; 24(20)2023 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37894732
4.
New Synthetic Isoxazole Derivatives Acting as Potent Inducers of Fetal Hemoglobin in Erythroid Precursor Cells Isolated from ß-Thalassemic Patients.
Molecules
; 29(1)2023 Dec 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38202591
5.
Treatment of Erythroid Precursor Cells from ß-Thalassemia Patients with Cinchona Alkaloids: Induction of Fetal Hemoglobin Production.
Int J Mol Sci
; 22(24)2021 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34948226
6.
Discovery of Novel Fetal Hemoglobin Inducers through Small Chemical Library Screening.
Int J Mol Sci
; 21(19)2020 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33050052
7.
Surface plasmon resonance based analysis of the binding of LYAR protein to the rs368698783 (G>A) polymorphic Aγ-globin gene sequences mutated in ß-thalassemia.
Anal Bioanal Chem
; 411(29): 7699-7707, 2019 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-31300855
8.
Development and characterization of cellular biosensors for HTS of erythroid differentiation inducers targeting the transcriptional activity of γ-globin and ß-globin gene promoters.
Anal Bioanal Chem
; 411(29): 7669-7680, 2019 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-31273412
9.
An Aγ-globin G->A gene polymorphism associated with ß039 thalassemia globin gene and high fetal hemoglobin production.
BMC Med Genet
; 18(1): 93, 2017 08 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-28851297
10.
BCL11A mRNA Targeting by miR-210: A Possible Network Regulating γ-Globin Gene Expression.
Int J Mol Sci
; 18(12)2017 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29186860
11.
A validated cellular biobank for ß-thalassemia.
J Transl Med
; 14: 255, 2016 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27590532
12.
Sex-specific transcriptional profiles identified in ß-thalassemia patients.
Haematologica
; 106(4): 1207-1211, 2021 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32817281
13.
Inhibitory effects of SARS-CoV-2 spike protein and BNT162b2 vaccine on erythropoietin-induced globin gene expression in erythroid precursor cells from patients with ß-thalassemia.
Exp Hematol
; 129: 104128, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37939833
14.
Increased Expression of α-Hemoglobin Stabilizing Protein (AHSP) mRNA in Erythroid Precursor Cells Isolated from ß-Thalassemia Patients Treated with Sirolimus (Rapamycin).
J Clin Med
; 13(9)2024 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38731008
15.
Effects of Sirolimus Treatment on Fetal Hemoglobin Production and Response to SARS-CoV-2 Vaccination: A Case Report Study.
Hematol Rep
; 15(3): 432-439, 2023 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37489374
16.
Effects of Mithramycin on BCL11A Gene Expression and on the Interaction of the BCL11A Transcriptional Complex to γ-Globin Gene Promoter Sequences.
Genes (Basel)
; 14(10)2023 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37895276
17.
Production and Characterization of K562 Cellular Clones Hyper-Expressing the Gene Encoding α-Globin: Preliminary Analysis of Biomarkers Associated with Autophagy.
Genes (Basel)
; 14(3)2023 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36980829
18.
The Long Scientific Journey of Sirolimus (Rapamycin): From the Soil of Easter Island (Rapa Nui) to Applied Research and Clinical Trials on ß-Thalassemia and Other Hemoglobinopathies.
Biology (Basel)
; 12(9)2023 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37759601
19.
A combined approach for ß-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction.
Ann Hematol
; 91(8): 1201-13, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22460946
20.
Co-Treatment of Erythroid Cells from ß-Thalassemia Patients with CRISPR-Cas9-Based ß039-Globin Gene Editing and Induction of Fetal Hemoglobin.
Genes (Basel)
; 13(10)2022 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36292612