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1.

Bat pluripotent stem cells reveal unusual entanglement between host and viruses.

Déjosez, Marion; Marin, Arturo; Hughes, Graham M; Morales, Ariadna E; Godoy-Parejo, Carlos; Gray, Jonathan L; Qin, Yiren; Singh, Arun A; Xu, Hui; Juste, Javier; Ibáñez, Carlos; White, Kris M; Rosales, Romel; Francoeur, Nancy J; Sebra, Robert P; Alcock, Dominic; Volkert, Thomas L; Puechmaille, Sébastien J; Pastusiak, Andrzej; Frost, Simon D W; Hiller, Michael; Young, Richard A; Teeling, Emma C; García-Sastre, Adolfo; Zwaka, Thomas P.

Cell ; 186(5): 957-974.e28, 2023 03 02.

Artigo em Inglês | MEDLINE | ID: mdl-36812912

2.

Pluripotency and nuclear reprogramming.

Dejosez, Marion; Zwaka, Thomas P.

Annu Rev Biochem ; 81: 737-65, 2012.

Artigo em Inglês | MEDLINE | ID: mdl-22443931

3.

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.

Riva, Laura; Yuan, Shuofeng; Yin, Xin; Martin-Sancho, Laura; Matsunaga, Naoko; Pache, Lars; Burgstaller-Muehlbacher, Sebastian; De Jesus, Paul D; Teriete, Peter; Hull, Mitchell V; Chang, Max W; Chan, Jasper Fuk-Woo; Cao, Jianli; Poon, Vincent Kwok-Man; Herbert, Kristina M; Cheng, Kuoyuan; Nguyen, Tu-Trinh H; Rubanov, Andrey; Pu, Yuan; Nguyen, Courtney; Choi, Angela; Rathnasinghe, Raveen; Schotsaert, Michael; Miorin, Lisa; Dejosez, Marion; Zwaka, Thomas P; Sit, Ko-Yung; Martinez-Sobrido, Luis; Liu, Wen-Chun; White, Kris M; Chapman, Mackenzie E; Lendy, Emma K; Glynne, Richard J; Albrecht, Randy; Ruppin, Eytan; Mesecar, Andrew D; Johnson, Jeffrey R; Benner, Christopher; Sun, Ren; Schultz, Peter G; Su, Andrew I; García-Sastre, Adolfo; Chatterjee, Arnab K; Yuen, Kwok-Yung; Chanda, Sumit K.

Nature ; 586(7827): 113-119, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-32707573

4.

Ronin governs the metabolic capacity of the embryonic lineage for post-implantation development.

Salewskij, Kirill; Gross-Thebing, Theresa; Ing-Simmons, Elizabeth; Duethorn, Binyamin; Rieger, Bettina; Fan, Rui; Chen, Rui; Govindasamy, Niraimathi; Brinkmann, Heike; Kremer, Ludmila; Kuempel-Rink, Nannette; Mildner, Karina; Zeuschner, Dagmar; Stehling, Martin; Dejosez, Marion; Zwaka, Thomas P; Schöler, Hans R; Busch, Karin B; Vaquerizas, Juan M; Bedzhov, Ivan.

EMBO Rep ; 22(11): e53048, 2021 11 04.

Artigo em Inglês | MEDLINE | ID: mdl-34515391

5.

Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells.

Dejosez, Marion; Krumenacker, Joshua S; Zitur, Laura Jo; Passeri, Marco; Chu, Li-Fang; Songyang, Zhou; Thomson, James A; Zwaka, Thomas P.

Cell ; 133(7): 1162-74, 2008 Jun 27.

Artigo em Inglês | MEDLINE | ID: mdl-18585351

6.

Mutations in THAP1/DYT6 reveal that diverse dystonia genes disrupt similar neuronal pathways and functions.

Zakirova, Zuchra; Fanutza, Tomas; Bonet, Justine; Readhead, Ben; Zhang, Weijia; Yi, Zhengzi; Beauvais, Genevieve; Zwaka, Thomas P; Ozelius, Laurie J; Blitzer, Robert D; Gonzalez-Alegre, Pedro; Ehrlich, Michelle E.

PLoS Genet ; 14(1): e1007169, 2018 01.

Artigo em Inglês | MEDLINE | ID: mdl-29364887

7.

Stem cells: The cost of perpetual youth.

Zwaka, Thomas P.

Nature ; 548(7666): 165-166, 2017 08 10.

Artigo em Inglês | MEDLINE | ID: mdl-28746313

8.

Ronin/Hcf-1 binds to a hyperconserved enhancer element and regulates genes involved in the growth of embryonic stem cells.

Dejosez, Marion; Levine, Stuart S; Frampton, Garrett M; Whyte, Warren A; Stratton, Sabrina A; Barton, Michelle C; Gunaratne, Preethi H; Young, Richard A; Zwaka, Thomas P.

Genes Dev ; 24(14): 1479-84, 2010 Jul 15.

Artigo em Inglês | MEDLINE | ID: mdl-20581084

9.

Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT.

Bisson, Joseph A; Mills, Bradley; Paul Helt, Jay-Christian; Zwaka, Thomas P; Cohen, Ethan David.

Dev Biol ; 398(1): 80-96, 2015 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-25482987

10.

GCNF-dependent activation of cyclin D1 expression via repression of Mir302a during ESC differentiation.

Wang, Hongran; Wang, Xiaohong; Archer, Trevor K; Zwaka, Thomas P; Cooney, Austin J.

Stem Cells ; 32(6): 1527-37, 2014 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-24578347

11.

p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells.

Jain, Abhinav K; Allton, Kendra; Iacovino, Michelina; Mahen, Elisabeth; Milczarek, Robert J; Zwaka, Thomas P; Kyba, Michael; Barton, Michelle Craig.

PLoS Biol ; 10(2): e1001268, 2012.

Artigo em Inglês | MEDLINE | ID: mdl-22389628

12.

Epigenetic reprogramming of the germ cell nuclear factor gene is required for proper differentiation of induced pluripotent cells.

Wang, Hongran; Wang, Xiaohong; Xu, Xueping; Zwaka, Thomas P; Cooney, Austin J.

Stem Cells ; 31(12): 2659-66, 2013 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-23495137

13.

Regulatory architecture of housekeeping genes is driven by promoter assemblies.

Dejosez, Marion; Dall'Agnese, Alessandra; Ramamoorthy, Mahesh; Platt, Jesse; Yin, Xing; Hogan, Megan; Brosh, Ran; Weintraub, Abraham S; Hnisz, Denes; Abraham, Brian J; Young, Richard A; Zwaka, Thomas P.

Cell Rep ; 42(5): 112505, 2023 05 30.

Artigo em Inglês | MEDLINE | ID: mdl-37182209

14.

Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection.

Wei, Jin; Patil, Ajinkya; Collings, Clayton K; Alfajaro, Mia Madel; Liang, Yu; Cai, Wesley L; Strine, Madison S; Filler, Renata B; DeWeirdt, Peter C; Hanna, Ruth E; Menasche, Bridget L; Ökten, Arya; Peña-Hernández, Mario A; Klein, Jon; McNamara, Andrew; Rosales, Romel; McGovern, Briana L; Luis Rodriguez, M; García-Sastre, Adolfo; White, Kris M; Qin, Yiren; Doench, John G; Yan, Qin; Iwasaki, Akiko; Zwaka, Thomas P; Qi, Jun; Kadoch, Cigall; Wilen, Craig B.

Nat Genet ; 55(3): 471-483, 2023 03.

Artigo em Inglês | MEDLINE | ID: mdl-36894709

15.

Caspase-3 cleavage links delta-catenin to the novel nuclear protein ZIFCAT.

Gu, Dongmin; Tonthat, Nam Ky; Lee, Moonsup; Ji, Hong; Bhat, Krishna P; Hollingsworth, Faith; Aldape, Kenneth D; Schumacher, Maria A; Zwaka, Thomas P; McCrea, Pierre D.

J Biol Chem ; 286(26): 23178-88, 2011 Jul 01.

Artigo em Inglês | MEDLINE | ID: mdl-21561870

16.

Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity.

Pohl, Marie O; Martin-Sancho, Laura; Ratnayake, Ranjala; White, Kris M; Riva, Laura; Chen, Qi-Yin; Lieber, Gauthier; Busnadiego, Idoia; Yin, Xin; Lin, Samuel; Pu, Yuan; Pache, Lars; Rosales, Romel; Déjosez, Marion; Qin, Yiren; De Jesus, Paul D; Beall, Anne; Yoh, Sunnie; Hale, Benjamin G; Zwaka, Thomas P; Matsunaga, Naoko; García-Sastre, Adolfo; Stertz, Silke; Chanda, Sumit K; Luesch, Hendrik.

ACS Infect Dis ; 8(7): 1265-1279, 2022 07 08.

Artigo em Inglês | MEDLINE | ID: mdl-35766385

17.

Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission.

Escalera, Alba; Gonzalez-Reiche, Ana S; Aslam, Sadaf; Mena, Ignacio; Laporte, Manon; Pearl, Rebecca L; Fossati, Andrea; Rathnasinghe, Raveen; Alshammary, Hala; van de Guchte, Adriana; Farrugia, Keith; Qin, Yiren; Bouhaddou, Mehdi; Kehrer, Thomas; Zuliani-Alvarez, Lorena; Meekins, David A; Balaraman, Velmurugan; McDowell, Chester; Richt, Jürgen A; Bajic, Goran; Sordillo, Emilia Mia; Dejosez, Marion; Zwaka, Thomas P; Krogan, Nevan J; Simon, Viviana; Albrecht, Randy A; van Bakel, Harm; García-Sastre, Adolfo; Aydillo, Teresa.

Cell Host Microbe ; 30(3): 373-387.e7, 2022 03 09.

Artigo em Inglês | MEDLINE | ID: mdl-35150638

18.

Breathing chromatin in pluripotent stem cells.

Zwaka, Thomas P.

Dev Cell ; 10(1): 1-2, 2006 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-16399069

19.

Stem cells: Troublesome memories.

Zwaka, Thomas P.

Nature ; 467(7313): 280-1, 2010 Sep 16.

Artigo em Inglês | MEDLINE | ID: mdl-20844526

20.

Ronin overexpression induces cerebellar degeneration in a mouse model of ataxia.

Zwaka, Thomas P; Skowronska, Marta; Richman, Ronald; Dejosez, Marion.

Dis Model Mech ; 14(6)2021 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-34165550

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Bat pluripotent stem cells reveal unusual entanglement between host and viruses.

Pluripotency and nuclear reprogramming.

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.

Ronin governs the metabolic capacity of the embryonic lineage for post-implantation development.

Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells.

Mutations in THAP1/DYT6 reveal that diverse dystonia genes disrupt similar neuronal pathways and functions.

Stem cells: The cost of perpetual youth.

Ronin/Hcf-1 binds to a hyperconserved enhancer element and regulates genes involved in the growth of embryonic stem cells.

Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT.

GCNF-dependent activation of cyclin D1 expression via repression of Mir302a during ESC differentiation.

p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells.

Epigenetic reprogramming of the germ cell nuclear factor gene is required for proper differentiation of induced pluripotent cells.

Regulatory architecture of housekeeping genes is driven by promoter assemblies.

Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection.

Caspase-3 cleavage links delta-catenin to the novel nuclear protein ZIFCAT.

Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity.

Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission.

Breathing chromatin in pluripotent stem cells.

Stem cells: Troublesome memories.

Ronin overexpression induces cerebellar degeneration in a mouse model of ataxia.