1.
Bioorg Med Chem Lett
; 18(1): 179-83, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18039577
RESUMO
Herein we report investigations into the p38alpha MAP kinase activity of trisubstituted imidazoles that led to the identification of compounds possessing highly potent in vivo activity. The SAR of a novel series of imidazopyridines is demonstrated as well, resulting in compounds possessing cellular potency and enhanced in vivo activity in the rat collagen-induced arthritis model of chronic inflammation.