Detalhe da pesquisa
1.
Selective small-molecule inhibition of an RNA structural element.
Nature
; 526(7575): 672-7, 2015 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-26416753
2.
Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation.
Bioorg Med Chem Lett
; 26(9): 2339-43, 2016 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27017115
3.
Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold.
Bioorg Med Chem Lett
; 26(23): 5695-5702, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27839686
4.
Pharmacologic inhibition of the renal outer medullary potassium channel causes diuresis and natriuresis in the absence of kaliuresis.
J Pharmacol Exp Ther
; 348(1): 153-64, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24142912
5.
Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
J Med Chem
; 65(24): 16234-16251, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36475645
6.
Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities.
Bioorg Med Chem Lett
; 20(20): 6088-92, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20832306
7.
Stimulation of Glucose-Dependent Insulin Secretion by a Potent, Selective sst3 Antagonist.
ACS Med Chem Lett
; 3(4): 289-93, 2012 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900466
8.
Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics.
ACS Med Chem Lett
; 3(5): 367-72, 2012 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900480