1.
Clin Infect Dis
; 50(3): 453, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20064034
2.
Clin Vaccine Immunol
; 16(6): 953-5, 2009 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19386797
RESUMO
To better understand the T-cell hyporesponsiveness of patients with paracoccidioidomycosis, we tested the hypothesis that the T cells were committed to apoptosis. We show here that T cells of patients with paracoccidioidomycosis overexpress caspase 9 and caspase 8 but express low Bcl-2 levels and that interleukin-2 was unable to revert the hyporesponsiveness. These data suggest that the T cells would in vivo be driven to a tolerant state and apoptosis.