RESUMO
This study reports on the emergence of OXA-48-like carbapenemases among isolates of Enterobacteriaceae in South Africa. In addition, the emergence during therapy of a colistin-resistant OXA-181-producing Klebsiella pneumoniae isolate was documented following selective digestive tract decontamination with oral colistin, which is therefore strongly discouraged.
Assuntos
Antibacterianos/uso terapêutico , Colistina/uso terapêutico , Farmacorresistência Bacteriana , Infecções por Enterobacteriaceae/epidemiologia , Enterobacteriaceae/enzimologia , Trato Gastrointestinal/microbiologia , beta-Lactamases/metabolismo , Antibacterianos/farmacologia , Colistina/farmacologia , Enterobacteriaceae/isolamento & purificação , Infecções por Enterobacteriaceae/tratamento farmacológico , Humanos , Masculino , Pessoa de Meia-Idade , África do Sul/epidemiologia , beta-Lactamases/genéticaRESUMO
Four sequential extended-spectrum beta -lactamase-producing isolates of Klebsiella pneumoniae were obtained from a patient after treatment with ertapenem and cultured. The first and fourth isolates were susceptible to ertapenem, whereas the second and third were resistant. All 4 isolates belonged to the same strain and produced a group 1 CTX-M enzyme; additionally, the resistant isolates had lost a porin.
Assuntos
Klebsiella pneumoniae/efeitos dos fármacos , Klebsiella pneumoniae/enzimologia , Pneumonia Bacteriana/microbiologia , Resistência beta-Lactâmica , beta-Lactamases/metabolismo , beta-Lactamas/farmacologia , Idoso de 80 Anos ou mais , Antibacterianos/farmacologia , Ertapenem , Humanos , Infecções por Klebsiella/microbiologia , Masculino , Testes de Sensibilidade Microbiana , Pneumonia Bacteriana/tratamento farmacológicoRESUMO
New, effective antibiotics are only likely to become available in 15 - 20 years. To prevent deaths from untreatable Gram-negative infections in South Africa, the rights of any doctor, whether in general or in hospital practice, to indiscriminately prescribe whatever antibiotic they wish, and in whatever fashion, must be challenged. Furthermore, although prevention of the emergence and subsequent spread of carbapenem-resistant Enterobacteriaceae (CRE) has focused on acute and chronic care facilities and inter alia on antibiotic exposure in these institutions, CRE may soon become an issue within entire communities, highlighting a role for public health authorities in CRE prevention efforts.