Detalhe da pesquisa
1.
Benefits in cardiac function by CD38 suppression: Improvement in NAD+ levels, exercise capacity, heart rate variability and protection against catecholamine-induced ventricular arrhythmias.
J Mol Cell Cardiol
; 166: 11-22, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35114253
2.
Ecto-CD38-NADase inhibition modulates cardiac metabolism and protects mice against doxorubicin-induced cardiotoxicity.
Cardiovasc Res
; 120(3): 286-300, 2024 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38271281
3.
Heavy-chain antibody targeting of CD38 NAD+ hydrolase ectoenzyme to prevent fibrosis in multiple organs.
Sci Rep
; 13(1): 22085, 2023 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38086958
4.
TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity.
MAbs
; 14(1): 2095949, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35867844
5.
TNB-486 induces potent tumor cell cytotoxicity coupled with low cytokine release in preclinical models of B-NHL.
MAbs
; 13(1): 1890411, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33818299
6.
Attenuating CD3 affinity in a PSMAxCD3 bispecific antibody enables killing of prostate tumor cells with reduced cytokine release.
J Immunother Cancer
; 9(6)2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34088740
7.
Rabbits transgenic for human IgG genes recapitulating rabbit B-cell biology to generate human antibodies of high specificity and affinity.
MAbs
; 12(1): 1846900, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33228444
8.
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels.
Nat Metab
; 2(11): 1284-1304, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33199925
9.
Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies.
MAbs
; 11(4): 639-652, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30698484
10.
The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging.
Trends Pharmacol Sci
; 39(4): 424-436, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29482842
11.
Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies.
Front Immunol
; 9: 3037, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30666250
12.
Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies.
Front Immunol
; 9: 889, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29740455
13.
Sequence analysis of 0.5 Mb of the rabbit germline immunoglobulin heavy chain locus.
Gene
; 330: 49-59, 2004 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-15087123
14.
In Vivo Persistence of Donor Cells following Adoptive Transfer of Allogeneic Dendritic Cells in HIV-Infected Patients.
Cell Transplant
; 9(3): 307-317, 2000 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-28880658