Pesquisa | Portal de Pesquisa da BVS

1.

Crystal Structure of Cleaved Serp-1, a Myxomavirus-Derived Immune Modulating Serpin: Structural Design of Serpin Reactive Center Loop Peptides with Improved Therapeutic Function.

Mahon, Brian P; Ambadapadi, Sriram; Yaron, Jordan R; Lomelino, Carrie L; Pinard, Melissa A; Keinan, Shahar; Kurnikov, Igor; Macaulay, Colin; Zhang, Liqiang; Reeves, Westley; McFadden, Grant; Tibbetts, Scott; McKenna, Robert; Lucas, Alexandra R.

Biochemistry ; 57(7): 1096-1107, 2018 02 20.

Artigo em Inglês | MEDLINE | ID: mdl-29227673

2.

Reactive Center Loop (RCL) Peptides Derived from Serpins Display Independent Coagulation and Immune Modulating Activities.

Ambadapadi, Sriram; Munuswamy-Ramanujam, Ganesh; Zheng, Donghang; Sullivan, Colin; Dai, Erbin; Morshed, Sufi; McFadden, Baron; Feldman, Emily; Pinard, Melissa; McKenna, Robert; Tibbetts, Scott; Lucas, Alexandra.

J Biol Chem ; 291(6): 2874-87, 2016 Feb 05.

Artigo em Inglês | MEDLINE | ID: mdl-26620556

3.

Interactions of cytosolic sulfotransferases with xenobiotics.

James, Margaret O; Ambadapadi, Sriram.

Drug Metab Rev ; 45(4): 401-14, 2013 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-24188364

4.

Virus-Derived Chemokine Modulating Protein Pre-Treatment Blocks Chemokine-Glycosaminoglycan Interactions and Significantly Reduces Transplant Immune Damage.

Zanetti, Isabela R; Burgin, Michelle; Zhang, Liqiang; Yeh, Steve T; Ambadapadi, Sriram; Kilbourne, Jacquelyn; Yaron, Jordan R; Lowe, Kenneth M; Daggett-Vondras, Juliane; Fonseca, David; Boyd, Ryan; Wakefield, Dara; Clapp, William; Lim, Efrem; Chen, Hao; Lucas, Alexandra.

Pathogens ; 11(5)2022 May 16.

Artigo em Inglês | MEDLINE | ID: mdl-35631109

5.

RNA Virus Gene Signatures Detected in Patients With Cardiomyopathy After Chemotherapy; A Pilot Study.

Varkoly, Kyle; Tan, Shaoyuan; Beladi, Roxana; Fonseca, David; Zanetti, Isabela Rivabem; Kraberger, Simona; Shah, Chintan; Yaron, Jordan R; Zhang, Liqiang; Juby, Michael; Fath, Ayman; Ambadapadi, Sriram; House, Melanie; Maranian, Paul; Pepine, Carl J; Varsani, Arvind; Moreb, Jan; Schultz-Cherry, Stacey; Lucas, Alexandra R.

Front Cardiovasc Med ; 9: 821162, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-35360008

6.

Deriving Immune-Modulating Peptides from Viral Serine Protease Inhibitors (Serpins).

Yaron, Jordan R; Zhang, Liqiang; Burgin, Michelle; Schutz, Lauren N; Awo, Enkidia A; Keinan, Shahar; McFadden, Grant; Ambadapadi, Sriram; Guo, Qiuyun; Chen, Hao; Lucas, Alexandra R.

Methods Mol Biol ; 2225: 107-123, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33108660

7.

Immune protection is dependent on the gut microbiome in a lethal mouse gammaherpesviral infection.

Yaron, Jordan R; Ambadapadi, Sriram; Zhang, Liqiang; Chavan, Ramani N; Tibbetts, Scott A; Keinan, Shahar; Varsani, Arvind; Maldonado, Juan; Kraberger, Simona; Tafoya, Amanda M; Bullard, Whitney L; Kilbourne, Jacquelyn; Stern-Harbutte, Alison; Krajmalnik-Brown, Rosa; Munk, Barbara H; Koppang, Erling O; Lim, Efrem S; Lucas, Alexandra R.

Sci Rep ; 10(1): 2371, 2020 02 11.

Artigo em Inglês | MEDLINE | ID: mdl-32047224

8.

Modifying the Organ Matrix Pre-engraftment: A New Transplant Paradigm?

Yaron, Jordan R; Kwiecien, Jacek M; Zhang, Liqiang; Ambadapadi, Sriram; Wakefield, Dara N; Clapp, William L; Dabrowski, Wojciech; Burgin, Michelle; Munk, Barbara H; McFadden, Grant; Chen, Hao; Lucas, Alexandra R.

Trends Mol Med ; 25(7): 626-639, 2019 07.

Artigo em Inglês | MEDLINE | ID: mdl-31109797

9.

Serp-2, a virus-derived apoptosis and inflammasome inhibitor, attenuates liver ischemia-reperfusion injury in mice.

Yaron, Jordan R; Chen, Hao; Ambadapadi, Sriram; Zhang, Liqiang; Tafoya, Amanda M; Munk, Barbara H; Wakefield, Dara N; Fuentes, Jorge; Marques, Bruno J; Harripersaud, Krishna; Bartee, Mee Yong; Davids, Jennifer A; Zheng, Donghang; Rand, Kenneth; Dixon, Lisa; Moyer, Richard W; Clapp, William L; Lucas, Alexandra R.

J Inflamm (Lond) ; 16: 12, 2019.

Artigo em Inglês | MEDLINE | ID: mdl-31160886

10.

Overview of Serpins and Their Roles in Biological Systems.

Lucas, Alexandra; Yaron, Jordan R; Zhang, Liqiang; Ambadapadi, Sriram.

Methods Mol Biol ; 1826: 1-7, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-30194590

11.

Kinetic Measurement of Serpin Inhibitory Activity by Real-Time Fluorogenic Biochemical Assay.

Yaron, Jordan R; Ambadapadi, Sriram; Zhang, Liqiang; Lucas, Alexandra.

Methods Mol Biol ; 1826: 65-71, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-30194593

12.

Viral Serpin Reactive Center Loop (RCL) Peptides: Design and Testing.

Zhang, Liqiang; Yaron, Jordan R; Ambadapadi, Sriram; Lucas, Alexandra.

Methods Mol Biol ; 1826: 133-142, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-30194598

13.

Analysis of In Vivo Serpin Functions in Models of Inflammatory Vascular Disease.

Chen, Hao; Ambadapadi, Sriram; Dai, Erbin; Liu, Liying; Yaron, Jordan R; Zhang, Liqiang; Lucas, Alexandra.

Methods Mol Biol ; 1826: 157-182, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-30194600

14.

Impaired innate immune signaling due to combined Toll-like receptor 2 and 4 deficiency affects both periodontitis and atherosclerosis in response to polybacterial infection.

Chukkapalli, Sasanka S; Ambadapadi, Sriram; Varkoly, Kyle; Jiron, Jessica; Aguirre, Jose Ignacio; Bhattacharyya, Indraneel; Morel, Laurence M; Lucas, Alexandra R; Kesavalu, Lakshmyya.

Pathog Dis ; 76(8)2018 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-30351354

15.

Selective Deletion of Heparan Sulfotransferase Enzyme, Ndst1, in Donor Endothelial and Myeloid Precursor Cells Significantly Decreases Acute Allograft Rejection.

Chen, Hao; Ambadapadi, Sriram; Wakefield, Dara; Bartee, Meeyong; Yaron, Jordan R; Zhang, Liqiang; Archer-Hartmann, Stephanie A; Azadi, Parastoo; Burgin, Michelle; Borges, Chad; Zheng, Donghang; Ergle, Kevin; Muppala, Vishnu; Morshed, Sufi; Rand, Kenneth; Clapp, William; Proudfoot, Amanda; Lucas, Alexandra.

Sci Rep ; 8(1): 13433, 2018 09 07.

Artigo em Inglês | MEDLINE | ID: mdl-30194334

16.

Celecoxib affects estrogen sulfonation catalyzed by several human hepatic sulfotransferases, but does not stimulate 17-sulfonation in rat liver.

Ambadapadi, Sriram; Wang, Peter L; Palii, Sergiu P; James, Margaret O.

J Steroid Biochem Mol Biol ; 172: 46-54, 2017 09.

Artigo em Inglês | MEDLINE | ID: mdl-28552400

17.

Sequential colonization of periodontal pathogens in induction of periodontal disease and atherosclerosis in LDLRnull mice.

Chukkapalli, Sasanka S; Easwaran, Meena; Rivera-Kweh, Mercedes F; Velsko, Irina M; Ambadapadi, Sriram; Dai, Jiayin; Larjava, Hannu; Lucas, Alexandra R; Kesavalu, Lakshmyya.

Pathog Dis ; 75(1)2017 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-28104616

18.

Atrial Fibrillation Ablation Increases Inflammation-Chemokine Modulation Suppresses Activation of Leukocytes Isolated after Ablation.

Al-Ani, Mohammad; Ambadapadi, Sriram; Yaron, Jordan R; Zheng, Donghang; Fortunel, Adisson; Doroton-Guevara, Maia; Liu, Liying; Morshed, Sufi; Fricker, Jay; Miles, William; McKillop, Matthew; Lucas, Alexandra.

Cardiovasc Hematol Disord Drug Targets ; 17(3): 195-204, 2017.

Artigo em Inglês | MEDLINE | ID: mdl-28925907

19.

Celecoxib influences steroid sulfonation catalyzed by human recombinant sulfotransferase 2A1.

Ambadapadi, Sriram; Wang, Peter L; Palii, Sergiu P; James, Margaret O.

J Steroid Biochem Mol Biol ; 152: 101-13, 2015 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-25960318

20.

Serpin treatment suppresses inflammatory vascular lesions in temporal artery implants (TAI) from patients with giant cell arteritis.

Chen, Hao; Zheng, Donghang; Ambadapadi, Sriram; Davids, Jennifer; Ryden, Sally; Samy, Hazem; Bartee, Mee; Sobel, Eric; Dai, Erbin; Liu, Liying; Macaulay, Colin; Yachnis, Anthony; Weyand, Cornelia; Thoburn, Robert; Lucas, Alexandra.

PLoS One ; 10(2): e0115482, 2015.

Artigo em Inglês | MEDLINE | ID: mdl-25658487

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