Pesquisa | Portal de Pesquisa da BVS

1.

A Proteomics Approach to Decipher a Sticky CHO Situation.

Kumar, Swetha; Kumar, Amit; Huhn, Steven; DeVine, Lauren; Cole, Robert; Du, Zhimei; Betenbaugh, Michael.

Biotechnol Bioeng ; 2022 Apr 25.

Artigo em Inglês | MEDLINE | ID: mdl-35470426

2.

Epigenetic comparison of CHO hosts and clones reveals divergent methylation and transcription patterns across lineages.

Chang, Meiping; Kumar, Amit; Kumar, Swetha; Huhn, Steven; Timp, Winston; Betenbaugh, Michael; Du, Zhimei.

Biotechnol Bioeng ; 119(4): 1062-1076, 2022 04.

Artigo em Inglês | MEDLINE | ID: mdl-35028935

3.

Significant impact of mTORC1 and ATF4 pathways in CHO cell recombinant protein production induced by CDK4/6 inhibitor.

Chang, Meiping; Huhn, Steven; Nelson, Luke; Betenbaugh, Michael; Du, Zhimei.

Biotechnol Bioeng ; 119(5): 1189-1206, 2022 05.

Artigo em Inglês | MEDLINE | ID: mdl-35112712

4.

Engineering redox sensors into CHO cells enables near-real-time quantification of intracellular redox in bioprocesses.

McFarland, Kevin S; Zhu, Jie; Sinharoy, Pritam; Betenbaugh, Michael J; Handlogten, Michael W.

Biotechnol Bioeng ; 119(6): 1439-1449, 2022 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-35182429

5.

Metabolic analysis of the asparagine and glutamine dynamics in an industrial Chinese hamster ovary fed-batch process.

Kirsch, Brian J; Bennun, Sandra V; Mendez, Adam; Johnson, Amy S; Wang, Hongxia; Qiu, Haibo; Li, Ning; Lawrence, Shawn M; Bak, Hanne; Betenbaugh, Michael J.

Biotechnol Bioeng ; 119(3): 807-819, 2022 03.

Artigo em Inglês | MEDLINE | ID: mdl-34786689

6.

A genome-scale nutrient minimization forecast algorithm for controlling essential amino acid levels in CHO cell cultures.

Chen, Yiqun; Liu, Xiao; Anderson, Ji Young L; Naik, Harnish Mukesh; Dhara, Venkata Gayatri; Chen, Xiaolu; Harris, Glenn A; Betenbaugh, Michael J.

Biotechnol Bioeng ; 119(2): 435-451, 2022 02.

Artigo em Inglês | MEDLINE | ID: mdl-34811743

7.

Attenuation of glutamine synthetase selection marker improves product titer and reduces glutamine overflow in Chinese hamster ovary cells.

Sacco, Sarah A; Tuckowski, Angela M; Trenary, Irina; Kraft, Lauren; Betenbaugh, Michael J; Young, Jamey D; Smith, Kevin D.

Biotechnol Bioeng ; 2022 Mar 21.

Artigo em Inglês | MEDLINE | ID: mdl-35312045

8.

The interplay of protein engineering and glycoengineering to fine-tune antibody glycosylation and its impact on effector functions.

Wang, Qiong; Wang, Tiexin; Zhang, Roushu; Yang, Shuang; McFarland, Kevin S; Chung, Cheng-Yu; Jia, Hongpeng; Wang, Lai-Xi; Cipollo, John F; Betenbaugh, Michael J.

Biotechnol Bioeng ; 119(1): 102-117, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-34647616

9.

SnapShot: N-Glycosylation Processing Pathways across Kingdoms.

Chung, Cheng-Yu; Majewska, Natalia I; Wang, Qiong; Paul, Jackson T; Betenbaugh, Michael J.

Cell ; 171(1): 258-258.e1, 2017 Sep 21.

Artigo em Inglês | MEDLINE | ID: mdl-28938118

10.

Glycoengineering of Aspergillus nidulans to produce precursors for humanized N-glycan structures.

Anyaogu, Diana Chinyere; Hansen, Anders Holmgaard; Hoof, Jakob Blæsbjerg; Majewska, Natalia I; Contesini, Fabiano Jares; Paul, Jackson T; Nielsen, Kristian Fog; Hobley, Timothy John; Yang, Shuang; Zhang, Hui; Betenbaugh, Michael; Mortensen, Uffe Hasbro.

Metab Eng ; 67: 153-163, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-34174425

11.

Elucidating the impact of cottonseed hydrolysates on CHO cell culture performance through transcriptomic analysis.

Kumar, Swetha; Dhara, Venkata Gayatri; Orzolek, Linda D; Hao, Haiping; More, Abbie J; Lau, Eduardo Catchon; Betenbaugh, Michael J.

Appl Microbiol Biotechnol ; 105(1): 271-285, 2021 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-33201275

12.

Non-Hodgkin Lymphoma Metabolism.

Kirsch, Brian James; Chang, Shu-Jyuan; Betenbaugh, Michael James; Le, Anne.

Adv Exp Med Biol ; 1311: 103-116, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-34014537

13.

COVID-19 Serology at Population Scale: SARS-CoV-2-Specific Antibody Responses in Saliva.

Pisanic, Nora; Randad, Pranay R; Kruczynski, Kate; Manabe, Yukari C; Thomas, David L; Pekosz, Andrew; Klein, Sabra L; Betenbaugh, Michael J; Clarke, William A; Laeyendecker, Oliver; Caturegli, Patrizio P; Larman, H Benjamin; Detrick, Barbara; Fairley, Jessica K; Sherman, Amy C; Rouphael, Nadine; Edupuganti, Srilatha; Granger, Douglas A; Granger, Steve W; Collins, Matthew H; Heaney, Christopher D.

J Clin Microbiol ; 59(1)2020 12 17.

Artigo em Inglês | MEDLINE | ID: mdl-33067270

14.

Metabolic engineering challenges of extending N-glycan pathways in Chinese hamster ovary cells.

Wang, Qiong; Wang, Tiexin; Yang, Shuang; Sha, Sha; Wu, Wells W; Chen, Yiqun; Paul, Jackson T; Shen, Rong-Fong; Cipollo, John F; Betenbaugh, Michael J.

Metab Eng ; 61: 301-314, 2020 09.

Artigo em Inglês | MEDLINE | ID: mdl-32663509

15.

The impact of sialylation linkage-type on the pharmacokinetics of recombinant butyrylcholinesterases.

Chung, Cheng-Yu; Wang, Qiong; Yang, Shuang; Chough, Sandra; Seo, Younji; Cipollo, John F; Balthasar, Joseph P; Betenbaugh, Michael J.

Biotechnol Bioeng ; 117(1): 157-166, 2020 01.

Artigo em Inglês | MEDLINE | ID: mdl-31544955

16.

The importance and future of biochemical engineering.

Whitehead, Timothy A; Banta, Scott; Bentley, William E; Betenbaugh, Michael J; Chan, Christina; Clark, Douglas S; Hoesli, Corinne A; Jewett, Michael C; Junker, Beth; Koffas, Mattheos; Kshirsagar, Rashmi; Lewis, Amanda; Li, Chien-Ting; Maranas, Costas; Terry Papoutsakis, E; Prather, Kristala L J; Schaffer, Steffen; Segatori, Laura; Wheeldon, Ian.

Biotechnol Bioeng ; 117(8): 2305-2318, 2020 08.

Artigo em Inglês | MEDLINE | ID: mdl-32343367

17.

Evidence for a mutualistic relationship between the cyanobacteria Nostoc and fungi Aspergilli in different environments.

Jiang, Liqun; Li, Tingting; Jenkins, Jackson; Hu, Yifeng; Brueck, Christopher L; Pei, Haiyan; Betenbaugh, Michael J.

Appl Microbiol Biotechnol ; 104(14): 6413-6426, 2020 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-32472175

18.

Chromosomal instability drives convergent and divergent evolution toward advantageous inherited traits in mammalian CHO bioproduction lineages.

Huhn, Steve; Chang, Meiping; Kumar, Amit; Liu, Ren; Jiang, Bo; Betenbaugh, Michael; Lin, Henry; Nyberg, Gregg; Du, Zhimei.

iScience ; 25(4): 104074, 2022 Apr 15.

Artigo em Inglês | MEDLINE | ID: mdl-35355517

19.

Comparative systeomics to elucidate physiological differences between CHO and SP2/0 cell lines.

Demirhan, Deniz; Kumar, Amit; Zhu, Jie; Poulsen, Pi Camilla; Majewska, Natalia I; Sebastian, Yinong; Chaerkady, Raghothama; Yu, Wen; Zhu, Wei; Zhuang, Li; Shah, Punit; Lekstrom, Kristen; Cole, Robert N; Zhang, Hui; Betenbaugh, Michael J; Bowen, Michael A.

Sci Rep ; 12(1): 3280, 2022 02 28.

Artigo em Inglês | MEDLINE | ID: mdl-35228567

20.

Adaptive immune responses in vaccinated patients with symptomatic SARS-CoV-2 Alpha infection.

Park, Han-Sol; Shapiro, Janna R; Sitaras, Ioannis; Woldemeskel, Bezawit A; Garliss, Caroline C; Dziedzic, Amanda; Sachithanandham, Jaiprasath; Jedlicka, Anne E; Caputo, Christopher A; Rousseau, Kimberly E; Thakar, Manjusha; Suwanmanee, San; Hauk, Pricila; Aliyu, Lateef; Majewska, Natalia I; Koley, Sushmita; Patel, Bela; Broderick, Patrick; Mosnaim, Giselle; Heath, Sonya L; Spivak, Emily S; Shenoy, Aarthi; Bloch, Evan M; Gniadek, Thomas J; Shoham, Shmuel; Casadevall, Arturo; Hanley, Daniel; Cox, Andrea L; Laeyendecker, Oliver; Betenbaugh, Michael J; Cramer, Steven M; Mostafa, Heba H; Pekosz, Andrew; Blankson, Joel N; Klein, Sabra L; Tobian, Aaron Ar; Sullivan, David; Gebo, Kelly A.

JCI Insight ; 7(5)2022 03 08.

Artigo em Inglês | MEDLINE | ID: mdl-35104245

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