Pesquisa | Portal de Pesquisa da BVS

1.

Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer.

Schirmer, Amelia U; Driver, Lucy M; Zhao, Megan T; Wells, Carrow I; Pickett, Julie E; O'Bryne, Sean N; Eduful, Benjamin J; Yang, Xuan; Howard, Lauren; You, Sungyong; Devi, Gayathri R; DiGiovanni, John; Freedland, Stephen J; Chi, Jen-Tsan; Drewry, David H; Macias, Everardo.

Mol Ther ; 30(1): 485-500, 2022 01 05.

Artigo em Inglês | MEDLINE | ID: mdl-34450249

2.

NUAK family kinase 2 is a novel therapeutic target for prostate cancer.

Fu, Weiwei; Zhao, Megan T; Driver, Lucy M; Schirmer, Amelia U; Yin, Qi; You, Sungyong; Freedland, Stephen J; DiGiovanni, John; Drewry, David H; Macias, Everardo.

Mol Carcinog ; 61(3): 334-345, 2022 03.

Artigo em Inglês | MEDLINE | ID: mdl-34818445

3.

Longitudinal Tibia Stress Fracture Risk During High-Volume Training: A Multiscale Modeling Pipeline Incorporating Bone Remodeling.

Pyles, Connor O; Dunphy, Melissa; Vavalle, Nicholas A; Vignos, Michael F; Luong, Quang T; Ott, Kyle; Drewry, David G.

J Biomech Eng ; 144(10)2022 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-35348634

4.

NEK5 activity regulates the mesenchymal and migratory phenotype in breast cancer cells.

Matossian, Margarite D; Elliott, Steven; Van Hoang, T; Burks, Hope E; Wright, Maryl K; Alzoubi, Madlin S; Yan, Thomas; Chang, Tiffany; Wathieu, Henri; Windsor, Gabrielle O; Hartono, Alifiani Bo; Lee, Sean; Zuercher, William J; Drewry, David H; Wells, Carrow; Kapadia, Nirav; Buechlein, Aaron; Fang, Fang; Nephew, Kenneth P; Collins-Burow, Bridgette M; Burow, Matthew E.

Breast Cancer Res Treat ; 189(1): 49-61, 2021 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-34196902

5.

The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification.

Wells, Carrow I; Al-Ali, Hassan; Andrews, David M; Asquith, Christopher R M; Axtman, Alison D; Dikic, Ivan; Ebner, Daniel; Ettmayer, Peter; Fischer, Christian; Frederiksen, Mathias; Futrell, Robert E; Gray, Nathanael S; Hatch, Stephanie B; Knapp, Stefan; Lücking, Ulrich; Michaelides, Michael; Mills, Caitlin E; Müller, Susanne; Owen, Dafydd; Picado, Alfredo; Saikatendu, Kumar S; Schröder, Martin; Stolz, Alexandra; Tellechea, Mariana; Turunen, Brandon J; Vilar, Santiago; Wang, Jinhua; Zuercher, William J; Willson, Timothy M; Drewry, David H.

Int J Mol Sci ; 22(2)2021 Jan 08.

Artigo em Inglês | MEDLINE | ID: mdl-33429995

6.

Synthesis and Evaluation of Novel 1,2,6-Thiadiazinone Kinase Inhibitors as Potent Inhibitors of Solid Tumors.

Kalogirou, Andreas S; East, Michael P; Laitinen, Tuomo; Torrice, Chad D; Maffuid, Kaitlyn A; Drewry, David H; Koutentis, Panayiotis A; Johnson, Gary L; Crona, Daniel J; Asquith, Christopher R M.

Molecules ; 26(19)2021 Sep 29.

Artigo em Inglês | MEDLINE | ID: mdl-34641454

7.

A novel screening approach comparing kinase activity of small molecule inhibitors with similar molecular structures and distinct biologic effects in triple-negative breast cancer to identify targetable signaling pathways.

Matossian, Margarite D; Burks, Hope E; Elliott, Steven; Hoang, Van T; Zuercher, William J; Wells, Carrow; Drewry, David H; Kapadia, Nirav; Chang, Tiffany; Yan, Thomas; Windsor, Gabrielle O; Nguyen, Khoa; Fang, Fang; Nephew, Kenneth P; Buechlein, Aaron; Rusch, Douglas B; Sabol, Rachel A; Ucar, Deniz A; Zabaleta, Jovanny; Miele, Lucio; Bunnell, Bruce A; Collins-Burow, Bridgette M; Burow, Matthew E.

Anticancer Drugs ; 31(8): 759-775, 2020 09.

Artigo em Inglês | MEDLINE | ID: mdl-32796402

8.

Concise, gram-scale synthesis of furo[2,3-b]pyridines with functional handles for chemoselective cross-coupling.

O'Byrne, Sean N; Eduful, Benjamin J; Willson, Timothy M; Drewry, David H.

Tetrahedron Lett ; 61(38)2020 Sep 17.

Artigo em Inglês | MEDLINE | ID: mdl-33012852

9.

Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity for the Atypical MAPK Kinase ERK3.

Schröder, Martin; Filippakopoulos, Panagis; Schwalm, Martin P; Ferrer, Carla A; Drewry, David H; Knapp, Stefan; Chaikuad, Apirat.

Int J Mol Sci ; 21(21)2020 Oct 26.

Artigo em Inglês | MEDLINE | ID: mdl-33114754

10.

In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds.

O'Byrne, Sean N; Scott, John W; Pilotte, Joseph R; Santiago, André da S; Langendorf, Christopher G; Oakhill, Jonathan S; Eduful, Benjamin J; Couñago, Rafael M; Wells, Carrow I; Zuercher, William J; Willson, Timothy M; Drewry, David H.

Molecules ; 25(2)2020 Jan 13.

Artigo em Inglês | MEDLINE | ID: mdl-31941153

11.

EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen.

Scheipl, Susanne; Barnard, Michelle; Cottone, Lucia; Jorgensen, Mette; Drewry, David H; Zuercher, William J; Turlais, Fabrice; Ye, Hongtao; Leite, Ana P; Smith, James A; Leithner, Andreas; Möller, Peter; Brüderlein, Silke; Guppy, Naomi; Amary, Fernanda; Tirabosco, Roberto; Strauss, Sandra J; Pillay, Nischalan; Flanagan, Adrienne M.

J Pathol ; 239(3): 320-34, 2016 07.

Artigo em Inglês | MEDLINE | ID: mdl-27102572

12.

E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition.

Burdova, Kamila; Yang, Hongbin; Faedda, Roberta; Hume, Samuel; Chauhan, Jagat; Ebner, Daniel; Kessler, Benedikt M; Vendrell, Iolanda; Drewry, David H; Wells, Carrow I; Hatch, Stephanie B; Dianov, Grigory L; Buffa, Francesca M; D'Angiolella, Vincenzo.

EMBO J ; 38(20): e101443, 2019 10 15.

Artigo em Inglês | MEDLINE | ID: mdl-31424118

13.

Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.

Drewry, David H; Annor-Gyamfi, Joel K; Wells, Carrow I; Pickett, Julie E; Dederer, Verena; Preuss, Franziska; Mathea, Sebastian; Axtman, Alison D.

J Med Chem ; 65(2): 1313-1328, 2022 01 27.

Artigo em Inglês | MEDLINE | ID: mdl-34333981

14.

Identification of 4-Anilinoquin(az)oline as a Cell-Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype.

Asquith, Christopher R M; Temme, Louisa; East, Michael P; Laitinen, Tuomo; Pickett, Julie; Kwarcinski, Frank E; Sinha, Parvathi; Wells, Carrow I; Johnson, Gary L; Zutshi, Reena; Drewry, David H.

ChemMedChem ; 17(12): e202200161, 2022 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-35403825

15.

Salt-Inducible Kinase 1 is a potential therapeutic target in Desmoplastic Small Round Cell Tumor.

Hartono, Alifiani Bonita; Kang, Hong-Jun; Shi, Lawrence; Phipps, Whitney; Ungerleider, Nathan; Giardina, Alexandra; Chen, WeiPing; Spraggon, Lee; Somwar, Romel; Moroz, Krzysztof; Drewry, David H; Burow, Matthew E; Flemington, Erik; Ladanyi, Marc; Lee, Sean Bong.

Oncogenesis ; 11(1): 18, 2022 Apr 20.

Artigo em Inglês | MEDLINE | ID: mdl-35443736

16.

MAP3K Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types.

Nguyen, Khoa; Tran, Minh N; Rivera, Andrew; Cheng, Thomas; Windsor, Gabrielle O; Chabot, Abraham B; Cavanaugh, Jane E; Collins-Burow, Bridgette M; Lee, Sean B; Drewry, David H; Flaherty, Patrick T; Burow, Matthew E.

Front Biosci (Landmark Ed) ; 27(5): 167, 2022 05 23.

Artigo em Inglês | MEDLINE | ID: mdl-35638434

17.

Temozolomide-induced guanine mutations create exploitable vulnerabilities of guanine-rich DNA and RNA regions in drug-resistant gliomas.

Tiek, Deanna M; Erdogdu, Beril; Razaghi, Roham; Jin, Lu; Sadowski, Norah; Alamillo-Ferrer, Carla; Hogg, J Robert; Haddad, Bassem R; Drewry, David H; Wells, Carrow I; Pickett, Julie E; Song, Xiao; Goenka, Anshika; Hu, Bo; Goldlust, Samuel A; Zuercher, William J; Pertea, Mihaela; Timp, Winston; Cheng, Shi-Yuan; Riggins, Rebecca B.

Sci Adv ; 8(25): eabn3471, 2022 06 24.

Artigo em Inglês | MEDLINE | ID: mdl-35731869

18.

Expression of Novel Kinase MAP3K19 in Various Cancers and Survival Correlations.

Nguyen, Khoa; Yousefi, Hassan; Cheng, Thomas; Magrath, Justin; Hartono, Alifiani B; Alzoubi, Madlin; Hebert, Katherine; Brock, Courtney K; Wright, Maryl K; Byrne, Charles Ethan; Rivera, Andrew; Okpechi, Sam C; Matossian, Margarite Delores; Wathieu, Henri; Elliott, Steven; Mondrinos, Mark J; Lee, Sean B; Collins-Burow, Bridgette M; Alahari, Suresh K; Drewry, David H; Burow, Matthew E.

Front Biosci (Landmark Ed) ; 27(6): 196, 2022 Jun 17.

Artigo em Inglês | MEDLINE | ID: mdl-35748272

19.

Target 2035 - update on the quest for a probe for every protein.

Müller, Susanne; Ackloo, Suzanne; Al Chawaf, Arij; Al-Lazikani, Bissan; Antolin, Albert; Baell, Jonathan B; Beck, Hartmut; Beedie, Shaunna; Betz, Ulrich A K; Bezerra, Gustavo Arruda; Brennan, Paul E; Brown, David; Brown, Peter J; Bullock, Alex N; Carter, Adrian J; Chaikuad, Apirat; Chaineau, Mathilde; Ciulli, Alessio; Collins, Ian; Dreher, Jan; Drewry, David; Edfeldt, Kristina; Edwards, Aled M; Egner, Ursula; Frye, Stephen V; Fuchs, Stephen M; Hall, Matthew D; Hartung, Ingo V; Hillisch, Alexander; Hitchcock, Stephen H; Homan, Evert; Kannan, Natarajan; Kiefer, James R; Knapp, Stefan; Kostic, Milka; Kubicek, Stefan; Leach, Andrew R; Lindemann, Sven; Marsden, Brian D; Matsui, Hisanori; Meier, Jordan L; Merk, Daniel; Michel, Maurice; Morgan, Maxwell R; Mueller-Fahrnow, Anke; Owen, Dafydd R; Perry, Benjamin G; Rosenberg, Saul H; Saikatendu, Kumar Singh; Schapira, Matthieu.

RSC Med Chem ; 13(1): 13-21, 2022 Jan 27.

Artigo em Inglês | MEDLINE | ID: mdl-35211674

20.

Severe Calcaneus Injury Probability Curves Due to Under-Body Blast.

Voo, Liming; Ott, Kyle; Metzger, Thomas; Merkle, Andrew; Drewry, David.

Ann Biomed Eng ; 49(11): 3118-3127, 2021 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-34117584

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