Pesquisa | Portal de Pesquisa da BVS

1.

Deep learning identifies synergistic drug combinations for treating COVID-19.

Jin, Wengong; Stokes, Jonathan M; Eastman, Richard T; Itkin, Zina; Zakharov, Alexey V; Collins, James J; Jaakkola, Tommi S; Barzilay, Regina.

Proc Natl Acad Sci U S A ; 118(39)2021 09 28.

Artigo em Inglês | MEDLINE | ID: mdl-34526388

2.

Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.

Abrams, Rachel P M; Yasgar, Adam; Teramoto, Tadahisa; Lee, Myoung-Hwa; Dorjsuren, Dorjbal; Eastman, Richard T; Malik, Nasir; Zakharov, Alexey V; Li, Wenxue; Bachani, Muzna; Brimacombe, Kyle; Steiner, Joseph P; Hall, Matthew D; Balasubramanian, Anuradha; Jadhav, Ajit; Padmanabhan, Radhakrishnan; Simeonov, Anton; Nath, Avindra.

Proc Natl Acad Sci U S A ; 117(49): 31365-31375, 2020 12 08.

Artigo em Inglês | MEDLINE | ID: mdl-33229545

3.

Synergistic and Antagonistic Drug Combinations against SARS-CoV-2.

Bobrowski, Tesia; Chen, Lu; Eastman, Richard T; Itkin, Zina; Shinn, Paul; Chen, Catherine Z; Guo, Hui; Zheng, Wei; Michael, Sam; Simeonov, Anton; Hall, Matthew D; Zakharov, Alexey V; Muratov, Eugene N.

Mol Ther ; 29(2): 873-885, 2021 02 03.

Artigo em Inglês | MEDLINE | ID: mdl-33333292

4.

Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection.

Shamim, Khalida; Xu, Miao; Hu, Xin; Lee, Emily M; Lu, Xiao; Huang, Ruili; Shah, Pranav; Xu, Xin; Chen, Catherine Z; Shen, Min; Guo, Hui; Chen, Lu; Itkin, Zina; Eastman, Richard T; Shinn, Paul; Klumpp-Thomas, Carleen; Michael, Sam; Simeonov, Anton; Lo, Donald C; Ming, Guo-Li; Song, Hongjun; Tang, Hengli; Zheng, Wei; Huang, Wenwei.

Bioorg Med Chem Lett ; 40: 127906, 2021 05 15.

Artigo em Inglês | MEDLINE | ID: mdl-33689873

5.

Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate.

Lisewski, Andreas Martin; Quiros, Joel P; Ng, Caroline L; Adikesavan, Anbu Karani; Miura, Kazutoyo; Putluri, Nagireddy; Eastman, Richard T; Scanfeld, Daniel; Regenbogen, Sam J; Altenhofen, Lindsey; Llinás, Manuel; Sreekumar, Arun; Long, Carole; Fidock, David A; Lichtarge, Olivier.

Cell ; 158(4): 916-928, 2014 Aug 14.

Artigo em Inglês | MEDLINE | ID: mdl-25126794

6.

Genome-wide profiling of chromosome interactions in Plasmodium falciparum characterizes nuclear architecture and reconfigurations associated with antigenic variation.

Lemieux, Jacob E; Kyes, Sue A; Otto, Thomas D; Feller, Avi I; Eastman, Richard T; Pinches, Robert A; Berriman, Matthew; Su, Xin-Zhuan; Newbold, Chris I.

Mol Microbiol ; 90(3): 519-37, 2013 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-23980881

7.

Small Molecule Antiviral Compound Collection (SMACC): a database to support the discovery of broad-spectrum antiviral drug molecules.

Martin, Holli-Joi; Melo-Filho, Cleber C; Korn, Daniel; Eastman, Richard T; Rai, Ganesha; Simeonov, Anton; Zakharov, Alexey V; Muratov, Eugene; Tropsha, Alexander.

bioRxiv ; 2022 Jul 11.

Artigo em Inglês | MEDLINE | ID: mdl-35860225

8.

A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model.

Dorjsuren, Dorjbal; Eastman, Richard T; Song, Min Jae; Yasgar, Adam; Chen, Yuchi; Bharti, Kapil; Zakharov, Alexey V; Jadhav, Ajit; Ferrer, Marc; Shi, Pei-Yong; Simeonov, Anton.

PLoS One ; 17(1): e0261821, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-35041689

9.

A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike.

Fu, Ying; Rezende E Mello, Juliana da Fonseca; Fleming, Bryan D; Renn, Alex; Chen, Catherine Z; Hu, Xin; Xu, Miao; Gorshkov, Kirill; Hanson, Quinlin; Zheng, Wei; Lee, Emily M; Perera, Lalith; Petrovich, Robert; Pradhan, Manisha; Eastman, Richard T; Itkin, Zina; Stanley, Thomas; Hsu, Allen; Dandey, Venkata; Gillette, William; Taylor, Troy; Ramakrishnan, Nitya; Perkins, Shelley; Esposito, Dominic; Oh, Eunkeu; Susumu, Kimihiro; Wolak, Mason; Ferrer, Marc; Hall, Matthew D; Borgnia, Mario J; Simeonov, Anton.

bioRxiv ; 2022 Mar 01.

Artigo em Inglês | MEDLINE | ID: mdl-34729560

10.

A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike.

Fu, Ying; da Fonseca Rezende E Mello, Juliana; Fleming, Bryan D; Renn, Alex; Chen, Catherine Z; Hu, Xin; Xu, Miao; Gorshkov, Kirill; Hanson, Quinlin; Zheng, Wei; Lee, Emily M; Perera, Lalith; Petrovich, Robert; Pradhan, Manisha; Eastman, Richard T; Itkin, Zina; Stanley, Thomas B; Hsu, Allen; Dandey, Venkata; Sharma, Kedar; Gillette, William; Taylor, Troy; Ramakrishnan, Nitya; Perkins, Shelley; Esposito, Dominic; Oh, Eunkeu; Susumu, Kimihiro; Wolak, Mason; Ferrer, Marc; Hall, Matthew D; Borgnia, Mario J; Simeonov, Anton.

PLoS One ; 17(8): e0272364, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-35947606

11.

Artemisinin resistance phenotypes and K13 inheritance in a Plasmodium falciparum cross and Aotus model.

Sá, Juliana M; Kaslow, Sarah R; Krause, Michael A; Melendez-Muniz, Viviana A; Salzman, Rebecca E; Kite, Whitney A; Zhang, Min; Moraes Barros, Roberto R; Mu, Jianbing; Han, Paul K; Mershon, J Patrick; Figan, Christine E; Caleon, Ramoncito L; Rahman, Rifat S; Gibson, Tyler J; Amaratunga, Chanaki; Nishiguchi, Erika P; Breglio, Kimberly F; Engels, Theresa M; Velmurugan, Soundarapandian; Ricklefs, Stacy; Straimer, Judith; Gnädig, Nina F; Deng, Bingbing; Liu, Anna; Diouf, Ababacar; Miura, Kazutoyo; Tullo, Gregory S; Eastman, Richard T; Chakravarty, Sumana; James, Eric R; Udenze, Kenneth; Li, Suzanne; Sturdevant, Daniel E; Gwadz, Robert W; Porcella, Stephen F; Long, Carole A; Fidock, David A; Thomas, Marvin L; Fay, Michael P; Sim, B Kim Lee; Hoffman, Stephen L; Adams, John H; Fairhurst, Rick M; Su, Xin-Zhuan; Wellems, Thomas E.

Proc Natl Acad Sci U S A ; 115(49): 12513-12518, 2018 12 04.

Artigo em Inglês | MEDLINE | ID: mdl-30455312

12.

Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites.

Dorjsuren, Dorjbal; Eastman, Richard T; Wicht, Kathryn J; Jansen, Daniel; Talley, Daniel C; Sigmon, Benjamin A; Zakharov, Alexey V; Roncal, Norma; Girvin, Andrew T; Antonova-Koch, Yevgeniya; Will, Paul M; Shah, Pranav; Sun, Hongmao; Klumpp-Thomas, Carleen; Mok, Sachel; Yeo, Tomas; Meister, Stephan; Marugan, Juan Jose; Ross, Leila S; Xu, Xin; Maloney, David J; Jadhav, Ajit; Mott, Bryan T; Sciotti, Richard J; Winzeler, Elizabeth A; Waters, Norman C; Campbell, Robert F; Huang, Wenwei; Simeonov, Anton; Fidock, David A.

Sci Rep ; 11(1): 2121, 2021 01 22.

Artigo em Inglês | MEDLINE | ID: mdl-33483532

13.

Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.

Le Manach, Claire; Dam, Jean; Woodland, John G; Kaur, Gurminder; Khonde, Lutete P; Brunschwig, Christel; Njoroge, Mathew; Wicht, Kathryn J; Horatscheck, André; Paquet, Tanya; Boyle, Grant A; Gibhard, Liezl; Taylor, Dale; Lawrence, Nina; Yeo, Tomas; Mok, Sachel; Eastman, Richard T; Dorjsuren, Dorjbal; Talley, Daniel C; Guo, Hui; Simeonov, Anton; Reader, Janette; van der Watt, Mariëtte; Erlank, Erica; Venter, Nelius; Zawada, Jacek W; Aswat, Ayesha; Nardini, Luisa; Coetzer, Theresa L; Lauterbach, Sonja B; Bezuidenhout, Belinda C; Theron, Anjo; Mancama, Dalu; Koekemoer, Lizette L; Birkholtz, Lyn-Marie; Wittlin, Sergio; Delves, Michael; Ottilie, Sabine; Winzeler, Elizabeth A; von Geldern, Thomas W; Smith, Dennis; Fidock, David A; Street, Leslie J; Basarab, Gregory S; Duffy, James; Chibale, Kelly.

J Med Chem ; 64(4): 2291-2309, 2021 02 25.

Artigo em Inglês | MEDLINE | ID: mdl-33573376

14.

Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19.

Eastman, Richard T; Roth, Jacob S; Brimacombe, Kyle R; Simeonov, Anton; Shen, Min; Patnaik, Samarjit; Hall, Matthew D.

ACS Cent Sci ; 6(5): 672-683, 2020 May 27.

Artigo em Inglês | MEDLINE | ID: mdl-32483554

15.

Correction to Remdesivir: A Review of Its Discovery and Development Leading to Human Clinical Trials for Treatment of COVID-19.

Eastman, Richard T; Roth, Jacob S; Brimacombe, Kyle R; Simeonov, Anton; Shen, Min; Patnaik, Samarjit; Hall, Matthew D.

ACS Cent Sci ; 6(6): 1009, 2020 06 24.

Artigo em Inglês | MEDLINE | ID: mdl-32607448

16.

Targeting ACE2-RBD interaction as a platform for COVID19 therapeutics: Development and drug repurposing screen of an AlphaLISA proximity assay.

Hanson, Quinlin M; Wilson, Kelli M; Shen, Min; Itkin, Zina; Eastman, Richard T; Shinn, Paul; Hall, Matthew D.

bioRxiv ; 2020 Jun 16.

Artigo em Inglês | MEDLINE | ID: mdl-32577632

17.

Targeting ACE2-RBD Interaction as a Platform for COVID-19 Therapeutics: Development and Drug-Repurposing Screen of an AlphaLISA Proximity Assay.

Hanson, Quinlin M; Wilson, Kelli M; Shen, Min; Itkin, Zina; Eastman, Richard T; Shinn, Paul; Hall, Matthew D.

ACS Pharmacol Transl Sci ; 3(6): 1352-1360, 2020 Dec 11.

Artigo em Inglês | MEDLINE | ID: mdl-33330843

18.

Discovery of Synergistic and Antagonistic Drug Combinations against SARS-CoV-2 In Vitro.

Bobrowski, Tesia; Chen, Lu; Eastman, Richard T; Itkin, Zina; Shinn, Paul; Chen, Catherine; Guo, Hui; Zheng, Wei; Michael, Sam; Simeonov, Anton; Hall, Matthew D; Zakharov, Alexey V; Muratov, Eugene N.

bioRxiv ; 2020 Jun 30.

Artigo em Inglês | MEDLINE | ID: mdl-32637956

19.

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2.

Chen, Catherine Z; Shinn, Paul; Itkin, Zina; Eastman, Richard T; Bostwick, Robert; Rasmussen, Lynn; Huang, Ruili; Shen, Min; Hu, Xin; Wilson, Kelli M; Brooks, Brianna M; Guo, Hui; Zhao, Tongan; Klump-Thomas, Carleen; Simeonov, Anton; Michael, Samuel G; Lo, Donald C; Hall, Matthew D; Zheng, Wei.

Front Pharmacol ; 11: 592737, 2020.

Artigo em Inglês | MEDLINE | ID: mdl-33708112

20.

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2.

Chen, Catherine Z; Shinn, Paul; Itkin, Zina; Eastman, Richard T; Bostwick, Robert; Rasmussen, Lynn; Huang, Ruili; Shen, Min; Hu, Xin; Wilson, Kelli M; Brooks, Brianna; Guo, Hui; Zhao, Tongan; Klump-Thomas, Carleen; Simeonov, Anton; Michael, Samuel G; Lo, Donald C; Hall, Matthew D; Zheng, Wei.

bioRxiv ; 2020 Aug 18.

Artigo em Inglês | MEDLINE | ID: mdl-32839771

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Deep learning identifies synergistic drug combinations for treating COVID-19.

Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.

Synergistic and Antagonistic Drug Combinations against SARS-CoV-2.

Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection.

Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate.

Genome-wide profiling of chromosome interactions in Plasmodium falciparum characterizes nuclear architecture and reconfigurations associated with antigenic variation.

Small Molecule Antiviral Compound Collection (SMACC): a database to support the discovery of broad-spectrum antiviral drug molecules.

A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model.

A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike.

A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike.

Artemisinin resistance phenotypes and K13 inheritance in a Plasmodium falciparum cross and Aotus model.

Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites.

Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.

Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19.

Correction to Remdesivir: A Review of Its Discovery and Development Leading to Human Clinical Trials for Treatment of COVID-19.

Targeting ACE2-RBD interaction as a platform for COVID19 therapeutics: Development and drug repurposing screen of an AlphaLISA proximity assay.

Targeting ACE2-RBD Interaction as a Platform for COVID-19 Therapeutics: Development and Drug-Repurposing Screen of an AlphaLISA Proximity Assay.

Discovery of Synergistic and Antagonistic Drug Combinations against SARS-CoV-2 In Vitro.

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2.

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2.