Pesquisa | Portal de Pesquisa da BVS

1.

Systems analysis and controlled malaria infection in Europeans and Africans elucidate naturally acquired immunity.

de Jong, Sanne E; van Unen, Vincent; Manurung, Mikhael D; Stam, Koen A; Goeman, Jelle J; Jochems, Simon P; Höllt, Thomas; Pezzotti, Nicola; Mouwenda, Yoanne D; Betouke Ongwe, Madeleine Eunice; Lorenz, Freia-Raphaella; Kruize, Yvonne C M; Azimi, Shohreh; König, Marion H; Vilanova, Anna; Eisemann, Elmar; Lelieveldt, Boudewijn P F; Roestenberg, Meta; Sim, B Kim Lee; Reinders, Marcel J T; Fendel, Rolf; Hoffman, Stephen L; Kremsner, Peter G; Koning, Frits; Mordmüller, Benjamin; Lell, Bertrand; Yazdanbakhsh, Maria.

Nat Immunol ; 22(5): 654-665, 2021 05.

Artigo em Inglês | MEDLINE | ID: mdl-33888898

2.

Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity.

Mwakingwe-Omari, Agnes; Healy, Sara A; Lane, Jacquelyn; Cook, David M; Kalhori, Sahand; Wyatt, Charles; Kolluri, Aarti; Marte-Salcedo, Omely; Imeru, Alemush; Nason, Martha; Ding, Lei K; Decederfelt, Hope; Duan, Junhui; Neal, Jillian; Raiten, Jacob; Lee, Grace; Hume, Jen C C; Jeon, Jihyun E; Ikpeama, Ijeoma; Kc, Natasha; Chakravarty, Sumana; Murshedkar, Tooba; Church, L W Preston; Manoj, Anita; Gunasekera, Anusha; Anderson, Charles; Murphy, Sean C; March, Sandra; Bhatia, Sangeeta N; James, Eric R; Billingsley, Peter F; Sim, B Kim Lee; Richie, Thomas L; Zaidi, Irfan; Hoffman, Stephen L; Duffy, Patrick E.

Nature ; 595(7866): 289-294, 2021 07.

Artigo em Inglês | MEDLINE | ID: mdl-34194041

3.

An efficient single-cell based method for linking human T cell phenotype to T cell receptor sequence and specificity.

Wahl, Ilka; Hoffmann, Sandro; Hundsdorfer, Rebecca; Puchan, Julia; Hoffman, Stephen L; Kremsner, Peter G; Mordmüller, Benjamin; Busse, Christian E; Wardemann, Hedda.

Eur J Immunol ; 52(2): 237-246, 2022 02.

Artigo em Inglês | MEDLINE | ID: mdl-34710239

4.

Knockout of Anopheles stephensi immune gene LRIM1 by CRISPR-Cas9 reveals its unexpected role in reproduction and vector competence.

Inbar, Ehud; Eappen, Abraham G; Alford, Robert T; Reid, William; Harrell, Robert A; Hosseini, Maryam; Chakravarty, Sumana; Li, Tao; Sim, B Kim Lee; Billingsley, Peter F; Hoffman, Stephen L.

PLoS Pathog ; 17(11): e1009770, 2021 11.

Artigo em Inglês | MEDLINE | ID: mdl-34784388

5.

PfSPZ-CVac efficacy against malaria increases from 0% to 75% when administered in the absence of erythrocyte stage parasitemia: A randomized, placebo-controlled trial with controlled human malaria infection.

Murphy, Sean C; Deye, Gregory A; Sim, B Kim Lee; Galbiati, Shirley; Kennedy, Jessie K; Cohen, Kristen W; Chakravarty, Sumana; Kc, Natasha; Abebe, Yonas; James, Eric R; Kublin, James G; Hoffman, Stephen L; Richie, Thomas L; Jackson, Lisa A.

PLoS Pathog ; 17(5): e1009594, 2021 05.

Artigo em Inglês | MEDLINE | ID: mdl-34048504

6.

Cellular and antibody response in GMZ2-vaccinated Gabonese volunteers in a controlled human malaria infection trial.

Nouatin, Odilon; Ibáñez, Javier; Fendel, Rolf; Ngoa, Ulysse A; Lorenz, Freia-Raphaella; Dejon-Agobé, Jean-Claude; Edoa, Jean Ronald; Flügge, Judith; Brückner, Sina; Esen, Meral; Theisen, Michael; Hoffman, Stephen L; Moutairou, Kabirou; Luty, Adrian J F; Lell, Bertrand; Kremsner, Peter G; Adegnika, Ayola A; Mordmüller, Benjamin.

Malar J ; 21(1): 191, 2022 Jun 17.

Artigo em Inglês | MEDLINE | ID: mdl-35715803

7.

Diagnostic performance and comparison of ultrasensitive and conventional rapid diagnostic test, thick blood smear and quantitative PCR for detection of low-density Plasmodium falciparum infections during a controlled human malaria infection study in Equatorial Guinea.

Mpina, Maxmillian; Stabler, Thomas C; Schindler, Tobias; Raso, Jose; Deal, Anna; Acuche Pupu, Ludmila; Nyakarungu, Elizabeth; Del Carmen Ovono Davis, Maria; Urbano, Vicente; Mtoro, Ali; Hamad, Ali; Lopez, Maria Silvia A; Pasialo, Beltran; Eyang, Marta Alene Owono; Rivas, Matilde Riloha; Falla, Carlos Cortes; García, Guillermo A; Momo, Juan Carlos; Chuquiyauri, Raul; Saverino, Elizabeth; Preston Church, L W; Kim Lee Sim, B; Manguire, Bonifacio; Tanner, Marcel; Maas, Carl; Abdulla, Salim; Billingsley, Peter F; Hoffman, Stephen L; Jongo, Said; Richie, Thomas L; Daubenberger, Claudia A.

Malar J ; 21(1): 99, 2022 Mar 24.

Artigo em Inglês | MEDLINE | ID: mdl-35331251

8.

Activation of TCR VÎ´1⁺ and VÎ´1^-VÎ´2^- Î³Î´ T Cells upon Controlled Infection with Plasmodium falciparum in Tanzanian Volunteers.

Rutishauser, Tobias; Lepore, Marco; Di Blasi, Daniela; Dangy, Jean-Pierre; Abdulla, Salim; Jongo, Said; Ramadhani, Kamaka; Sim, B Kim Lee; Hoffman, Stephen L; Tanner, Marcel; Daubenberger, Claudia; De Libero, Gennaro.

J Immunol ; 204(1): 180-191, 2020 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-31801816

9.

Multidose Priming and Delayed Boosting Improve Plasmodium falciparum Sporozoite Vaccine Efficacy Against Heterologous P. falciparum Controlled Human Malaria Infection.

Lyke, Kirsten E; Singer, Alexandra; Berry, Andrea A; Reyes, Sharina; Chakravarty, Sumana; James, Eric R; Billingsley, Peter F; Gunasekera, Anusha; Manoj, Anita; Murshedkar, Tooba; Laurens, Matthew B; Church, W Preston; Garver Baldwin, Lindsey S; Sedegah, Martha; Banania, Glenna; Ganeshan, Harini; Guzman, Ivelese; Reyes, Anatalio; Wong, Mimi; Belmonte, Arnel; Ozemoya, Amelia; Belmonte, Maria; Huang, Jun; Villasante, Eileen; Sim, B Kim Lee; Hoffman, Stephen L; Richie, Thomas L; Epstein, Judith E.

Clin Infect Dis ; 73(7): e2424-e2435, 2021 10 05.

Artigo em Inglês | MEDLINE | ID: mdl-32920641

10.

Role of human Pegivirus infections in whole Plasmodium falciparum sporozoite vaccination and controlled human malaria infection in African volunteers.

Tumbo, Anneth-Mwasi; Schindler, Tobias; Dangy, Jean-Pierre; Orlova-Fink, Nina; Bieri, Jose Raso; Mpina, Maximillian; Milando, Florence A; Juma, Omar; Hamad, Ali; Nyakarungu, Elizabeth; Chemba, Mwajuma; Mtoro, Ali; Ramadhan, Kamaka; Olotu, Ally; Makweba, Damas; Mgaya, Stephen; Stuart, Kenneth; Perreau, Matthieu; Stapleton, Jack T; Jongo, Said; Hoffman, Stephen L; Tanner, Marcel; Abdulla, Salim; Daubenberger, Claudia.

Virol J ; 18(1): 28, 2021 01 26.

Artigo em Inglês | MEDLINE | ID: mdl-33499880

11.

Early whole blood transcriptional responses to radiation-attenuated Plasmodium falciparum sporozoite vaccination in malaria naïve and malaria pre-exposed adult volunteers.

Duffy, Fergal J; Du, Ying; Carnes, Jason; Epstein, Judith E; Hoffman, Stephen L; Abdulla, Salim; Jongo, Said; Mpina, Maxmillian; Daubenberger, Claudia; Aitchison, John D; Stuart, Ken.

Malar J ; 20(1): 308, 2021 Jul 09.

Artigo em Inglês | MEDLINE | ID: mdl-34243763

12.

Transient knockdown of Anopheles stephensi LRIM1 using RNAi increases Plasmodium falciparum sporozoite salivary gland infections.

Billingsley, Peter F; George, Kasim I; Eappen, Abraham G; Harrell, Robert A; Alford, Robert; Li, Tao; Chakravarty, Sumana; Sim, B Kim Lee; Hoffman, Stephen L; O'Brochta, David A.

Malar J ; 20(1): 284, 2021 Jun 26.

Artigo em Inglês | MEDLINE | ID: mdl-34174879

13.

Incidence of Plasmodium falciparum malaria infection in 6-month to 45-year-olds on selected areas of Bioko Island, Equatorial Guinea.

Nchama, Vicente Urbano Nsue Ndong; Said, Ali Hamad; Mtoro, Ali; Bidjimi, Gertrudis Owono; Owono, Marta Alene; Maye, Escolastica Raquel Mansogo; Mangue, Martin Eka Ondo; Okomo, Genaro Nsue Nguema; Pasialo, Beltran Ekua Ntutumu; Ondo, Dolores Mbang; Lopez, Maria-Silvia Angue; Mochomuemue, Fortunata Lobede; Obono, Mariano Obiang; Besaha, Juan Carlos Momo; Chuquiyauri, Raul; Jongo, Said Abdallah; Kamaka, Kassim; Kibondo, Ummi Abdul; Athuman, Thabit; Falla, Carlos Cortez; Eyono, Jeremías Nzamio Mba; Smith, Jordan Michael; García, Guillermo A; Raso, José; Nyakarungu, Elizabeth; Mpina, Maxmillian; Schindler, Tobias; Daubenberger, Claudia; Lemiale, Laurence; Billingsley, Peter F; Sim, B Kim Lee; Richie, Thomas L; Church, L W Preston; Olotu, Ally; Tanner, Marcel; Hoffman, Stephen L; Abdulla, Salim.

Malar J ; 20(1): 322, 2021 Jul 20.

Artigo em Inglês | MEDLINE | ID: mdl-34284778

14.

A Mosquito Pick-and-Place System for PfSPZ-based Malaria Vaccine Production.

Phalen, Henry; Vagdargi, Prasad; Schrum, Mariah L; Chakravarty, Sumana; Canezin, Amanda; Pozin, Michael; Coemert, Suat; Iordachita, Iulian; Hoffman, Stephen L; Chirikjian, Gregory S; Taylor, Russell H.

IEEE Trans Autom Sci Eng ; 18(1): 299-310, 2021 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-33746641

15.

Serologic Markers of Previous Malaria Exposure and Functional Antibodies Inhibiting Parasite Growth Are Associated With Parasite Kinetics Following a Plasmodium falciparum Controlled Human Infection.

Achan, Jane; Reuling, Isaie J; Yap, Xi Zen; Dabira, Edgard; Ahmad, Abdullahi; Cox, Momodou; Nwakanma, Davis; Tetteh, Kevin; Wu, Lindsey; Bastiaens, Guido J H; Abebe, Yonas; Manoj, Anita; Kaur, Harparkash; Miura, Kazutoyo; Long, Carole; Billingsley, Peter F; Sim, B Kim Lee; Hoffman, Stephen L; Drakeley, Chris; Bousema, Teun; D'Alessandro, Umberto.

Clin Infect Dis ; 70(12): 2544-2552, 2020 06 10.

Artigo em Inglês | MEDLINE | ID: mdl-31402382

16.

Safety, Tolerability, and Immunogenicity of Plasmodium falciparum Sporozoite Vaccine Administered by Direct Venous Inoculation to Infants and Young Children: Findings From an Age De-escalation, Dose-Escalation, Double-blind, Randomized Controlled Study in Western Kenya.

Steinhardt, Laura C; Richie, Thomas L; Yego, Reuben; Akach, Dorcas; Hamel, Mary J; Gutman, Julie R; Wiegand, Ryan E; Nzuu, Elizabeth L; Dungani, Allan; Kc, Natasha; Murshedkar, Tooba; Church, L W Preston; Sim, B Kim Lee; Billingsley, Peter F; James, Eric R; Abebe, Yonas; Kariuki, Simon; Samuels, Aaron M; Otieno, Kephas; Sang, Tony; Kachur, S Patrick; Styers, David; Schlessman, Kelly; Abarbanell, Ginnie; Hoffman, Stephen L; Seder, Robert A; Oneko, Martina.

Clin Infect Dis ; 71(4): 1063-1071, 2020 08 14.

Artigo em Inglês | MEDLINE | ID: mdl-31555824

17.

Increase of Dose Associated With Decrease in Protection Against Controlled Human Malaria Infection by PfSPZ Vaccine in Tanzanian Adults.

Jongo, Said A; Church, L W Preston; Mtoro, Ali T; Schindler, Tobias; Chakravarty, Sumana; Ruben, Adam J; Swanson, Phillip A; Kassim, Kamaka R; Mpina, Maximillian; Tumbo, Anneth-Mwasi; Milando, Florence A; Qassim, Munira; Juma, Omar A; Bakari, Bakari M; Simon, Beatus; James, Eric R; Abebe, Yonas; Kc, Natasha; Saverino, Elizabeth; Fink, Martina; Cosi, Glenda; Gondwe, Linda; Studer, Fabian; Styers, David; Seder, Robert A; Schindler, Tobias; Billingsley, Peter F; Daubenberger, Claudia; Sim, B Kim Lee; Tanner, Marcel; Richie, Thomas L; Abdulla, Salim; Hoffman, Stephen L.

Clin Infect Dis ; 71(11): 2849-2857, 2020 12 31.

Artigo em Inglês | MEDLINE | ID: mdl-31782768

18.

Recombinase Polymerase Amplification and Lateral Flow Assay for Ultrasensitive Detection of Low-Density Plasmodium falciparum Infection from Controlled Human Malaria Infection Studies and Naturally Acquired Infections.

Lalremruata, Albert; Nguyen, The Trong; McCall, Matthew B B; Mombo-Ngoma, Ghyslain; Agnandji, Selidji T; Adegnika, Ayôla A; Lell, Bertrand; Ramharter, Michael; Hoffman, Stephen L; Kremsner, Peter G; Mordmüller, Benjamin.

J Clin Microbiol ; 58(5)2020 04 23.

Artigo em Inglês | MEDLINE | ID: mdl-32102854

19.

Quantification of Plasmodium knowlesi versus Plasmodium falciparum in the rhesus liver: implications for malaria vaccine studies in rhesus models.

Shears, Melanie J; Seilie, Annette M; Kim Lee Sim, B; Hoffman, Stephen L; Murphy, Sean C.

Malar J ; 19(1): 313, 2020 Aug 31.

Artigo em Inglês | MEDLINE | ID: mdl-32867784

20.

Caregiver and community perceptions and experiences participating in an infant malaria prevention trial of PfSPZ Vaccine administered by direct venous inoculation: a qualitative study in Siaya County, western Kenya.

Achieng, Florence; Rosen, Joseph G; Cherop, Reuben Yego; Kariuki, Simon; Hoffman, Stephen L; Seder, Robert; Oneko, Martina; Steinhardt, Laura C.

Malar J ; 19(1): 226, 2020 Jun 24.

Artigo em Inglês | MEDLINE | ID: mdl-32580719

Portal de Pesquisa da BVS

Informação e Conhecimento para a Saúde

Configurar filtros

Sua seleção (0)

Formato de exportação:

Exportar: