Pesquisa | Portal de Pesquisa da BVS

1.

Targeting TNFα produced by astrocytes expressing amyotrophic lateral sclerosis-linked mutant fused in sarcoma prevents neurodegeneration and motor dysfunction in mice.

Jensen, Brigid K; McAvoy, Kevin J; Heinsinger, Nicolette M; Lepore, Angelo C; Ilieva, Hristelina; Haeusler, Aaron R; Trotti, Davide; Pasinelli, Piera.

Glia ; 70(7): 1426-1449, 2022 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-35474517

2.

A mouse model with widespread expression of the C9orf72-linked glycine-arginine dipeptide displays non-lethal ALS/FTD-like phenotypes.

Verdone, Brandie Morris; Cicardi, Maria Elena; Wen, Xinmei; Sriramoji, Sindhu; Russell, Katelyn; Markandaiah, Shashirekha S; Jensen, Brigid K; Krishnamurthy, Karthik; Haeusler, Aaron R; Pasinelli, Piera; Trotti, Davide.

Sci Rep ; 12(1): 5644, 2022 Apr 04.

Artigo em Inglês | MEDLINE | ID: mdl-35379876

3.

Synaptic dysfunction induced by glycine-alanine dipeptides in C9orf72-ALS/FTD is rescued by SV2 replenishment.

Jensen, Brigid K; Schuldi, Martin H; McAvoy, Kevin; Russell, Katelyn A; Boehringer, Ashley; Curran, Bridget M; Krishnamurthy, Karthik; Wen, Xinmei; Westergard, Thomas; Ma, Le; Haeusler, Aaron R; Edbauer, Dieter; Pasinelli, Piera; Trotti, Davide.

EMBO Mol Med ; 12(5): e10722, 2020 05 08.

Artigo em Inglês | MEDLINE | ID: mdl-32347002

4.

HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via ß-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation.

Gannon, Patrick J; Akay-Espinoza, Cagla; Yee, Alan C; Briand, Lisa A; Erickson, Michelle A; Gelman, Benjamin B; Gao, Yan; Haughey, Norman J; Zink, M Christine; Clements, Janice E; Kim, Nicholas S; Van De Walle, Gabriel; Jensen, Brigid K; Vassar, Robert; Pierce, R Christopher; Gill, Alexander J; Kolson, Dennis L; Diehl, J Alan; Mankowski, Joseph L; Jordan-Sciutto, Kelly L.

Am J Pathol ; 187(1): 91-109, 2017 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-27993242

5.

Reduced sterol regulatory element-binding protein (SREBP) processing through site-1 protease (S1P) inhibition alters oligodendrocyte differentiation in vitro.

Monnerie, Hubert; Romer, Micah; Jensen, Brigid K; Millar, John S; Jordan-Sciutto, Kelly L; Kim, Sangwon F; Grinspan, Judith B.

J Neurochem ; 140(1): 53-67, 2017 01.

Artigo em Inglês | MEDLINE | ID: mdl-27385127

6.

Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system.

Akay, Cagla; Cooper, Michael; Odeleye, Akinleye; Jensen, Brigid K; White, Michael G; Vassoler, Fair; Gannon, Patrick J; Mankowski, Joseph; Dorsey, Jamie L; Buch, Alison M; Cross, Stephanie A; Cook, Denise R; Peña, Michelle-Marie; Andersen, Emily S; Christofidou-Solomidou, Melpo; Lindl, Kathryn A; Zink, M Christine; Clements, Janice; Pierce, R Christopher; Kolson, Dennis L; Jordan-Sciutto, Kelly L.

J Neurovirol ; 20(1): 39-53, 2014 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-24420448

7.

White matter loss and oligodendrocyte dysfunction in HIV: A consequence of the infection, the antiretroviral therapy or both?

Jensen, Brigid K; Roth, Lindsay M; Grinspan, Judith B; Jordan-Sciutto, Kelly L.

Brain Res ; 1724: 146397, 2019 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-31442414

8.

Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD.

Westergard, Thomas; Jensen, Brigid K; Wen, Xinmei; Cai, Jingli; Kropf, Elizabeth; Iacovitti, Lorraine; Pasinelli, Piera; Trotti, Davide.

Cell Rep ; 17(3): 645-652, 2016 10 11.

Artigo em Inglês | MEDLINE | ID: mdl-27732842

9.

Altered Oligodendrocyte Maturation and Myelin Maintenance: The Role of Antiretrovirals in HIV-Associated Neurocognitive Disorders.

Jensen, Brigid K; Monnerie, Hubert; Mannell, Maggie V; Gannon, Patrick J; Espinoza, Cagla Akay; Erickson, Michelle A; Bruce-Keller, Annadora J; Gelman, Benjamin B; Briand, Lisa A; Pierce, R Christopher; Jordan-Sciutto, Kelly L; Grinspan, Judith B.

J Neuropathol Exp Neurol ; 74(11): 1093-118, 2015 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-26469251

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